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Human DLL4 Protein expressed in Human Cells - ABIN2002236
Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002
Show all 6 Pubmed References
Results show that DLL4 is involved in SYNJ2BP (显示 SYNJ2BP 蛋白)-induced hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) development though activating its pathway.
Positive Jagged1 (显示 JAG1 蛋白) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with gallbladder cancers.
We show that GIT1, which also contains an ANK domain, inhibits the Notch1 (显示 NOTCH1 蛋白)-Dll4 signaling pathway by competing with Notch1 (显示 NOTCH1 蛋白) ANK domain for binding to RBP-J (显示 RBPJ 蛋白) in stalk cells
Results provide evidence that DLL4 is associated with gastric cancer stem/progenitor cells (GCSPCs), and its expression impacts CSPC (显示 GZMH 蛋白) stemness characteristics associated with the Notch-1 (显示 NOTCH1 蛋白) pathway including self-renewal, differentiation, proliferation, and tumor formation.
The authors present novel structures of human ligands Jagged2 (显示 JAG2 蛋白) and Delta-like4 and human Notch2 (显示 NOTCH2 蛋白), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (显示 NOTCH1 蛋白) binding is likely to be critical in establishing the optimal context for Notch (显示 NOTCH1 蛋白) signalling.
Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (显示 BCL2 蛋白) expression, while decreasing Bax (显示 BAX 蛋白) expression, apoptosis rate and DNA damage
In gastric epithelial cells co-cultured with Helicobacter pylori, the expression level of the ligand DLL4 was found to be significantly increased.
Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.
Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (显示 VEGFA 蛋白) isoform-dependent manner, and in perivascular cells in a VEGF (显示 VEGFA 蛋白)-independent manner. The contribution of VEGF-A (显示 VEGFA 蛋白) isoforms to disease progression also indicates that IH may be associated with altered splicing.
Dll4 modulates liver inflammatory response by down-regulating chemokine (显示 CCL1 蛋白) expression
Dll4 seems to promote Apc (显示 APC 蛋白) (Min/+) tumorigenesis.
Dll4-Notch1 (显示 NOTCH1 蛋白) signalling couples sprouting angiogenesis and artery formation.
Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.
DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.
The results demonstrate that the Vegf (显示 VEGFA 蛋白)-Dll4/Notch (显示 NOTCH1 蛋白) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.
Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (显示 NOTCH1 蛋白) Signaling
miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression
Dll4/Notch (显示 NOTCH1 蛋白) signaling and HIF-1alpha (显示 HIF1A 蛋白) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Dll4-induced Notch1 (显示 NOTCH1 蛋白) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.
Tmem230a may have a modulatory role in vessel-network formation and growth, regulating endothelial cell number by Dll4/Notch (显示 NOTCH1 蛋白) pathway.
Thsd7a (显示 THSD7A 蛋白) could regulate ISV angiogenesis via Notch (显示 NOTCH1 蛋白)-dll4 signaling. Thus, Thsd7a (显示 THSD7A 蛋白) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (显示 NOTCH1 蛋白) signalling via down-regulation of dll4
Microinjection of miR (显示 MYLIP 蛋白)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (显示 NOTCH1 蛋白) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (显示 NOTCH1 蛋白) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (显示 NOTCH1 蛋白) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.
Vegfc (显示 VEGFC 蛋白)/Flt4 (显示 FLT4 蛋白) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2