DLL4 蛋白 (DLL4)产品概述

Full name:
delta-Like 4 蛋白 (DLL4)
在www.antibodies-online.cn可供28 delta-Like 4 (DLL4) 蛋白的9不同的供货商。 再加上,我们可以发DLL4 抗体 (170)DLL4 试剂盒 (24)和数多这个蛋白质的别的产品。 总共232 DLL4产品已列进来了。
Delta4, hdelta2, si:ch211-244p18.5, zgc:136596
列出全部蛋白 基因 基因ID UniProt
DLL4 54567 Q9NR61
DLL4 54485 Q9JI71
DLL4 311332  


按照种类DLL4 蛋白 (DLL4)


引用最多的DLL4 蛋白

  1. Human DLL4 Protein expressed in Human Cells - ABIN2002238 : Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002 (PubMed)
    Show all 5 references for 2002238

  2. Mouse (Murine) DLL4 Protein expressed in Human Cells - ABIN2008088 : Dufraine, Funahashi, Kitajewski: Notch signaling regulates tumor angiogenesis by diverse mechanisms. in Oncogene 2008 (PubMed)
    Show all 4 references for 2008088

  3. Human DLL4 Protein expressed in HEK-293 Cells - ABIN2180973 : Zhang, Henzel: Signal peptide prediction based on analysis of experimentally verified cleavage sites. in Protein science : a publication of the Protein Society 2004 (PubMed)
    Show all 2 references for 2180973


Human delta-Like 4 (DLL4) interaction partners

  1. The authors present novel structures of human ligands Jagged2 (显示 JAG2 蛋白) and Delta-like4 and human Notch2 (显示 NOTCH2 蛋白), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (显示 NOTCH1 蛋白) binding is likely to be critical in establishing the optimal context for Notch (显示 NOTCH1 蛋白) signalling.

  2. Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (显示 BCL2 蛋白) expression, while decreasing Bax (显示 BAX 蛋白) expression, apoptosis rate and DNA damage

  3. In gastric epithelial cells co-cultured with Helicobacter pylori, the expression level of the ligand DLL4 was found to be significantly increased.

  4. Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection.

  5. Angiogenesis in Infantile haemangioma (IH) appears to be controlled by DLL4 within the endothelium in a VEGF-A (显示 VEGFA 蛋白) isoform-dependent manner, and in perivascular cells in a VEGF (显示 VEGFA 蛋白)-independent manner. The contribution of VEGF-A (显示 VEGFA 蛋白) isoforms to disease progression also indicates that IH may be associated with altered splicing.

  6. Dll4 modulates liver inflammatory response by down-regulating chemokine (显示 CCL1 蛋白) expression

  7. Positive Jagged1 (显示 JAG1 蛋白) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with pancreatic ductal carcinoma.

  8. Data show that the IgA/delta-like protein 4 (Delta-4)/Notch (显示 NOTCH1 蛋白) receptor (Notch (显示 NOTCH1 蛋白)) axis is not observed in IgG-dendritic cells (DCs).

  9. Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.

  10. our data indicate that high DLL4 expression predicts pelvic lymph node metastasis and poor survival in cervical cancer. Therefore, DLL4 may be a potential clinical diagnostic marker for patients with early-stage cervical cancer.

Mouse (Murine) delta-Like 4 (DLL4) interaction partners

  1. Dll4 seems to promote Apc (显示 APC 蛋白) (Min/+) tumorigenesis.

  2. Dll4-Notch1 (显示 NOTCH1 蛋白) signalling couples sprouting angiogenesis and artery formation.

  3. Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.

  4. DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.

  5. The results demonstrate that the Vegf (显示 VEGFA 蛋白)-Dll4/Notch (显示 NOTCH1 蛋白) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.

  6. Dll4 modulates liver inflammatory response by down-regulating chemokine (显示 CCL1 蛋白) expression

  7. Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (显示 NOTCH1 蛋白) Signaling

  8. miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression

  9. Dll4/Notch (显示 NOTCH1 蛋白) signaling and HIF-1alpha (显示 HIF1A 蛋白) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.

  10. Dll4-induced Notch1 (显示 NOTCH1 蛋白) activity is required to specify the arterial programme in the aorta-gonad-mesonephros embryonic region.

Zebrafish delta-Like 4 (DLL4) interaction partners

  1. Thsd7a (显示 THSD7A 蛋白) could regulate ISV angiogenesis via Notch (显示 NOTCH1 蛋白)-dll4 signaling. Thus, Thsd7a (显示 THSD7A 蛋白) is a potent angioneurin involved in the development of both neural and vascular systems.

  2. show that blood flow suppresses vascular Notch (显示 NOTCH1 蛋白) signalling via down-regulation of dll4

  3. Microinjection of miR (显示 MYLIP 蛋白)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.

  4. Notch (显示 NOTCH1 蛋白) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (显示 NOTCH1 蛋白) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.

  5. These studies imply critical roles for Dll4/Notch (显示 NOTCH1 蛋白) signaling in the formation and wiring of the lymphatic network.

  6. Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf.

  7. Vegfc (显示 VEGFC 蛋白)/Flt4 (显示 FLT4 蛋白) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.



This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.

Alternative names and synonyms associated with DLL4

  • delta-like 4 (Drosophila) (DLL4)
  • delta-like 4 (Drosophila) (Dll4)
  • delta-like 4 (Drosophila) (dll4)
  • Delta4 蛋白
  • hdelta2 蛋白
  • si:ch211-244p18.5 蛋白
  • zgc:136596 蛋白

Protein level used designations for delta-Like 4 蛋白 (DLL4)

delta-like protein 4 , delta 4 , delta ligand 4 , delta-like 4 homolog , delta-like 4 protein , delta4 , drosophila Delta homolog 4 , notch ligand DLL4 , notch ligand delta-2

100057073 Equus caballus
100152163 Sus scrofa
54567 Homo sapiens
54485 Mus musculus
311332 Rattus norvegicus
453344 Pan troglodytes
607575 Canis lupus familiaris
518746 Bos taurus
563920 Danio rerio
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