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TAK1 regulates Nrf2 (显示 GABPA ELISA试剂盒) through modulation of Keap-p62/SQSTM1 (显示 SQSTM1 ELISA试剂盒) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (显示 FLNA ELISA试剂盒) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (显示 FLNA ELISA试剂盒) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
This paper highlights that targeting the BMP and TGFbeta (显示 TGFB1 ELISA试剂盒) type I and type II receptors causes a downregulation of XIAP (显示 XIAP ELISA试剂盒), TAK1, and Id1 (显示 ID1 ELISA试剂盒) leading to cell death of lung cancer cells.
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (显示 TLR4 ELISA试剂盒)-mediated JNK (显示 MAPK8 ELISA试剂盒) and p38 MAPK (显示 MAPK14 ELISA试剂盒) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
Tnfr1 (显示 TNFRSF1A ELISA试剂盒) deletion partially restored thymic and lung macrophages.
TAK1 (显示 NR2C2 ELISA试剂盒) is required for PPARgamma (显示 PPARG ELISA试剂盒) transactivation and promotes PPARgamma (显示 PPARG ELISA试剂盒) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (显示 TAB1 ELISA试剂盒)).
inhibition of TAK1 (显示 NR2C2 ELISA试剂盒) triggered two caspase 8 (显示 CASP8 ELISA试剂盒) activation pathways through the induction of RIP1 (显示 RALBP1 ELISA试剂盒)-FADD (显示 FADD ELISA试剂盒)-caspase 8 (显示 CASP8 ELISA试剂盒) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) development.
TAK1 (显示 NR2C2 ELISA试剂盒) regulates Nrf2 (显示 NFE2L2 ELISA试剂盒) through modulation of Keap-p62/SQSTM1 (显示 SQSTM1 ELISA试剂盒) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Mekk1 (显示 MAP2K1 ELISA试剂盒) (encoded by Map3k1 (显示 MAP3K1 ELISA试剂盒)) signaling activates Mapks to regulate Cdkn1b (显示 CDKN1B ELISA试剂盒) (encoding p27(Kip1 (显示 CDKN1B ELISA试剂盒))) expression and p27(Kip1 (显示 CDKN1B ELISA试剂盒))-dependent proliferative expansion in response to antigen.
TRADD (显示 TRADD ELISA试剂盒) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (显示 NR2C2 ELISA试剂盒)/p38 MAPK (显示 MAPK14 ELISA试剂盒) but not AKT (显示 AKT1 ELISA试剂盒) phosphorylation
this study demonstrates a pivotal role of TAK1 (显示 NR2C2 ELISA试剂盒) in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 (显示 NR2C2 ELISA试剂盒) function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards
The E3 ligase TRIM8 (显示 TRIM8 ELISA试剂盒) is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1.
Angiotensin-II up-regulates the Ampkalpha1 (显示 PRKAA1 ELISA试剂盒) isoform in renal tissue. Ampkalpha1 (显示 PRKAA1 ELISA试剂盒) participates in renal Tak1 (显示 NR2C2 ELISA试剂盒) activation and Tak1 (显示 NR2C2 ELISA试剂盒)-dependent signaling induced by angiotensin-II.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1