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our results demonstrated that miR (显示 MLXIP ELISA试剂盒)-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM (显示 ATM ELISA试剂盒) and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (显示 EWSR1 ELISA试剂盒)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (显示 PRKAA1 ELISA试剂盒), and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (显示 EWSR1 ELISA试剂盒)-CREB1 (显示 CREB1 ELISA试剂盒) and EWSR1 (显示 EWSR1 ELISA试剂盒)-ATF1 genetic fusions.
ATF-1 mediates HO-1 (显示 HMOX1 ELISA试剂盒) induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1 (显示 EWSR1 ELISA试剂盒)-ATF1 fusion.
Differential expression of CREB (显示 CREB1 ELISA试剂盒)/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB (显示 CREB1 ELISA试剂盒)/ATF system.
An increase in phosphorylation of CREB (显示 CREB1 ELISA试剂盒)/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.
the HSF1 (显示 HSF1 ELISA试剂盒) complex, including BRG1 (显示 SMARCA4 ELISA试剂盒) and lysine acetyltransferases p300 (显示 NOTCH1 ELISA试剂盒) and CREB-binding protein (CBP (显示 CREBBP ELISA试剂盒)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (显示 HMOX1 ELISA试剂盒) regulates DC maturation and function by modulating the p38 MAPK (显示 MAPK14 ELISA试剂盒)-CREB (显示 CREB1 ELISA试剂盒)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (显示 SULT2A1 ELISA试剂盒))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (显示 GPR34 ELISA试剂盒), since silencing of Gnalpha11 leads to the abolition of the DHEAS (显示 SULT2A1 ELISA试剂盒)-induced stimulation of Erk1/2 (显示 MAPK1/3 ELISA试剂盒), ATF-1, and CREB (显示 CREB1 ELISA试剂盒).
indicate that dysregulation of p38 MAPK (显示 MAPK14 ELISA试剂盒)-CREB (显示 CREB1 ELISA试剂盒)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (显示 NFE2L2 ELISA试剂盒)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (显示 MLXIP ELISA试剂盒)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (显示 RPS6KA3 ELISA试剂盒) and that RSK2 (显示 RPS6KA3 ELISA试剂盒)-ATF1 signaling plays an important role in EGF (显示 EGF ELISA试剂盒)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB (显示 CREB ELISA试剂盒)) at the time of zygotic genome activation
MSK1 (显示 RPS6KA5 ELISA试剂盒) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (显示 CREB1 ELISA试剂盒) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (显示 MAPK1 ELISA试剂盒) pathway is required for epidermal growth factor (显示 EGF ELISA试剂盒)-induced c-jun (显示 JUN ELISA试剂盒) expression
Data indicate increasing expression for CREB (显示 CREB1 ELISA试剂盒), ATF1, and ATF3 (显示 ATF3 ELISA试剂盒) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1