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抗Human AFT1 抗体:
抗Mouse (Murine) AFT1 抗体:
抗Rat (Rattus) AFT1 抗体:
Pin1 (显示 PIN1 抗体) is a novel regulator of ATF1 at Thr184.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1 (显示 EWSR1 抗体)-ATF1 gene fusion.
Results expand the spectrum of tumor types harboring EWSR1 (显示 EWSR1 抗体)/FUS (显示 FUS 抗体)-ATF1 gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.
Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1 (显示 EWSR1 抗体)-AFT1/CREB1 (显示 CREB1 抗体)/CREM (显示 CREM 抗体) fusions.
our results demonstrated that miR (显示 MLXIP 抗体)-30a may modulate the radiosensitivity of non-small cell lung cancer (NSCLC) through reducing the function of ATF1 in phosphorylation of ATM (显示 ATM 抗体) and have potential therapeutic value.
genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (显示 EWSR1 抗体)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (显示 PRKAA1 抗体), and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (显示 EWSR1 抗体)-CREB1 (显示 CREB1 抗体) and EWSR1 (显示 EWSR1 抗体)-ATF1 genetic fusions.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (显示 UTS2R 抗体) of ATF1/2, and indicates a difference between short and long isoforms.
the HSF1 (显示 HSF1 抗体) complex, including BRG1 (显示 SMARCA4 抗体) and lysine acetyltransferases p300 (显示 NOTCH1 抗体) and CREB-binding protein (CBP (显示 CREBBP 抗体)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (显示 HMOX1 抗体) regulates DC maturation and function by modulating the p38 MAPK (显示 MAPK14 抗体)-CREB (显示 CREB1 抗体)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (显示 SULT2A1 抗体))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (显示 GPR34 抗体), since silencing of Gnalpha11 leads to the abolition of the DHEAS (显示 SULT2A1 抗体)-induced stimulation of Erk1/2 (显示 MAPK1/3 抗体), ATF-1, and CREB (显示 CREB1 抗体).
indicate that dysregulation of p38 MAPK (显示 MAPK14 抗体)-CREB (显示 CREB1 抗体)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (显示 NFE2L2 抗体)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (显示 MLXIP 抗体)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (显示 RPS6KA3 抗体) and that RSK2 (显示 RPS6KA3 抗体)-ATF1 signaling plays an important role in EGF (显示 EGF 抗体)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation
MSK1 (显示 RPS6KA5 抗体) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (显示 CREB1 抗体) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (显示 MAPK1 抗体) pathway is required for epidermal growth factor (显示 EGF 抗体)-induced c-jun (显示 JUN 抗体) expression
Data indicate increasing expression for CREB (显示 CREB1 抗体), ATF1, and ATF3 (显示 ATF3 抗体) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1