anti-RPS6KA3 (RPS6KA3) 抗体产品概述

Full name:
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 抗体 (RPS6KA3)
在www.antibodies-online.cn可供253 Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) 抗体的24不同的供货商。 再加上,我们可以发RPS6KA3 蛋白 (14)RPS6KA3 试剂盒 (9)和数多这个蛋白质的别的产品。 总共287 RPS6KA3产品已列进来了。
别名:
90kDa, CLS, D17Wsu134e, HU-3, ISPK-1, MAPKAPK1B, MPK-9, MRX19, p90-RSK2, p90rsk, pp90rsk, pp90RSK2, RPS6KA, Rps6ka-rs1, RSK, Rsk2, Rsk3, S6K-alpha3
列出全部抗体 基因 基因ID UniProt
RPS6KA3 6197 P51812
RPS6KA3 20112 Q9WUT3

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  1. Human Polyclonal RPS6KA3 Primary Antibody for EIA - ABIN358394 : Yang, Matsuda, Bialek, Jacquot, Masuoka, Schinke, Li, Brancorsini, Sassone-Corsi, Townes, Hanauer, Karsenty: ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. in Cell 2004 (PubMed)
    Show all 5 references for 358394

  2. Human Monoclonal RPS6KA3 Primary Antibody for ICC, FACS - ABIN969386 : Dehan, Bassermann, Guardavaccaro, Vasiliver-Shamis, Cohen, Lowes, Dustin, Huang, Taunton, Pagano: betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis. in Molecular cell 2009 (PubMed)
    Show all 2 references for 969386

  3. Human Polyclonal RPS6KA3 Primary Antibody for IF, IHC - ABIN1532382 : Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006 (PubMed)

更多抗RPS6KA3的相互作用对抗体

Mouse (Murine) Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. The expressions of PDK1, p-PDK1, RSK2 and p-RSK2 were all up-regulated (显示 PDPK1 抗体)in collagen-induced arthritis compared with normal. This indicated that P (显示 PDPK1 抗体)DK1/RSK2 may participate in inflammatory progress of (显示 PDPK1 抗体) RA.

  2. The purified protein can be fully activated in vitro by phosphorylation with protein kinases ERK2 (显示 MAPK1 抗体) and PDK1 (显示 PDPK1 抗体).

  3. Downregulation of Rps6ka3 is a promising strategy for the treatment of multiple sclerosis.

  4. Data show that the phosphoinositide-dependent kinase 1 (PDK1 (显示 PDPK1 抗体))-p90 (显示 GPAM 抗体) kDa ribosomal S6 kinases (Rsks) Rsk1 (显示 RPS6KA1 抗体)/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.

  5. RSK2 regulates craniofacial development including tooth development and patterning via novel transcriptional targets

  6. The results of this study show that RSK2 loss-of-function is associated in the dentate gyrus with multi-level alterations that encompass modifications of glutamate (显示 GRIN1 抗体) receptor channel properties, synaptic transmission.

  7. We propose that loss of function mutations in RSK2 that lead to Coffin-Lowry syndrome are related to defects in neuronal growth due to impaired RSK2-dependent PLD1 activity resulting in a reduced vesicle fusion rate and membrane supply.

  8. RSK2 interacted and phosphorylated GSK-3beta (显示 GSK3b 抗体) at Ser9. Notably, GSK-3beta (显示 GSK3b 抗体) phosphorylation at Ser9 was suppressed in RSK2(-/-) mouse embryonic fibroblasts.

  9. Pin1 (显示 PIN1 抗体) plays a critical role in tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation

  10. This study showed that RSK2 signaling contributes to morphine analgesia in the tail withdrawal response.

Human Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 3 (RPS6KA3) interaction partners

  1. Inhibition of RSK2 was used to investigate the function of RSK2 on PDK1 (显示 PDK1 抗体)-induced inflammation. The phosphorylation of RSK2 was detected when PDK1 (显示 PDK1 抗体) was inhibited. Inhibition of RSK2 reduced the PDK1 (显示 PDK1 抗体)-induced cell invasion and cytokines secretion in human rheumatoid arthritis synovial MH7A cells. In response to TNF-alpha (显示 TNF 抗体), PDK1 (显示 PDK1 抗体) could phosphorylate RSK2 and activated RSK2, then promoting the activation of NF-kappaB (显示 NFKB1 抗体).

  2. Our finding demonstrates that RSK2 directly phosphorylates stathmin (显示 STMN1 抗体) and regulates microtubule polymerization to provide a pro-invasive and pro-metastatic advantage to cancer cells. Therefore, the RSK2-stathmin (显示 STMN1 抗体) pathway represents a promising therapeutic target and a prognostic marker for metastatic human cancers.

  3. we discuss the function of the RSK2 signaling axis by interactions with binding partners in cancer development--{REVIEW}

  4. Results showed that RSK2 gene was overexpressed in osteosarcoma patients cells and its knockdown increased cell apoptosis, enhanced cell chemosensitivity, inhibits proliferation and migration, and weakened tumor formation.

  5. Upregulated expression of RSK2 is associated with breast cancer.

  6. Data show that the 90 kDa ribosomal protein S6 (显示 RPS6 抗体) kinases RSK1 (显示 RPS6KA1 抗体) and RSK2 play a key role in the homing of ovarian cancer cells in metastatic sites by regulating cell adhesion and invasion.

  7. RSK1 (显示 RPS6KA1 抗体) and 3 but not RSK2 are down-regulated in breast tumour and are associated with disease progression. RSK (显示 RPS6KA1 抗体) may be a key component in the progression and metastasis of breast cancer.

  8. This case is one of the few examples where RPS6KA3 mutations are associated with a non-specific X-linked mental retardation.

  9. Results indicate that the phosphorylation of EphA2 (显示 EPHA2 抗体) at Ser (显示 SIGLEC1 抗体)-897 is controlled by RSK (显示 RPS6KA1 抗体) and the RSK (显示 RPS6KA1 抗体)-EphA2 (显示 EPHA2 抗体) axis might contribute to cell motility and promote tumour malignant progression.

  10. miR (显示 MLXIP 抗体)-191 represses proliferation in primary human fibroblasts via targeting multiple proto-oncogenes, including CDK9 (显示 CDK9 抗体), NOTCH2 (显示 NOTCH2 抗体), and RPS6KA3.

RPS6KA3 抗原简介

Antigen Summary

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

Alternative names and synonyms associated with RPS6KA3

  • ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3) 抗体
  • ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1) 抗体
  • ribosomal protein S6 kinase, polypeptide 2 (Rps6ka2) 抗体
  • ribosomal protein S6 kinase polypeptide 3 (Rps6ka3) 抗体
  • 90kDa 抗体
  • CLS 抗体
  • D17Wsu134e 抗体
  • HU-3 抗体
  • ISPK-1 抗体
  • MAPKAPK1B 抗体
  • MPK-9 抗体
  • MRX19 抗体
  • p90-RSK2 抗体
  • p90rsk 抗体
  • pp90rsk 抗体
  • pp90RSK2 抗体
  • RPS6KA 抗体
  • Rps6ka-rs1 抗体
  • RSK 抗体
  • Rsk2 抗体
  • Rsk3 抗体
  • S6K-alpha3 抗体

Protein level used designations for RPS6KA3

MAP kinase-activated protein kinase 1b , MAPK-activated protein kinase 1b , MAPKAP kinase 1b , MAPKAPK-1b , RSK-2 , S6K-alpha-3 , insulin-stimulated protein kinase 1 , p90-RSK 3 , ribosomal S6 kinase 2 , ribosomal protein S6 kinase alpha-3 , MAP kinase-activated protein kinase 1 , MAPK-activated protein kinase 1 , MAPKAP kinase 1 , MAPKAPK-1 , S6KII-alpha , p90-RSK , ribosomal protein S6 kinase 2 alpha , ribosomal protein S6 kinase II alpha , 90 kDa ribosomal protein S6 kinase 2 , MAP kinase-activated protein kinase 1c , MAPK-activated protein kinase 1c , MAPKAP kinase 1c , MAPKAPK-1c , RSK-3 , S6K-alpha 2 , S6K-alpha-2 , p90-RSK 2 , p90RSK2 , pp90RSK3 , protein-tyrosine kinase Mpk-9 , ribosomal S6 kinase 3 , ribosomal protein S6 kinase alpha 2 , ribosomal protein S6 kinase alpha-2 , ribosomal protein S6 kinase, 90kD, polypeptide 2 , 90 kDa ribosomal protein S6 kinase 3 , p90RSK3 , ribosomal protein S6 kinase 2

GENE ID SPECIES
6197 Homo sapiens
386579 Gallus gallus
20112 Mus musculus
110651 Mus musculus
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