Use your antibodies-online credentials, if available.
抗Human BCL2 抗体:
抗Rat (Rattus) BCL2 抗体:
抗Mouse (Murine) BCL2 抗体:
Human Monoclonal BCL2 Primary Antibody for ICC, IHC (fro) - ABIN3044481
Jiang, Li, Zhou, Wang, Zhang, Wang: Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways. in International journal of molecular medicine 2014
Show all 91 Pubmed References
Human Polyclonal BCL2 Primary Antibody for ELISA, WB - ABIN3042814
Zong, Li, Lin, Hou, Ma: Lipoxin A4 pretreatment mitigates skeletal muscle ischemia-reperfusion injury in rats. in American journal of translational research 2017
Show all 79 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF, IHC (p) - ABIN388095
Zheng, Zhou, Ye, Li, Bai, Zhang: The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells. in World journal of surgical oncology 2010
Show all 19 Pubmed References
Human Monoclonal BCL2 Primary Antibody for IHC (fro), FACS - ABIN967312
Batistatou, Merry, Korsmeyer, Greene: Bcl-2 affects survival but not neuronal differentiation of PC12 cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1993
Show all 13 Pubmed References
Mouse (Murine) Monoclonal BCL2 Primary Antibody for FM, IHC (fro) - ABIN967441
Hockenbery, Nuñez, Milliman, Schreiber, Korsmeyer: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. in Nature 1991
Show all 10 Pubmed References
Human Monoclonal BCL2 Primary Antibody for IHC (f), IHC (fro) - ABIN967321
Krajewski, Tanaka, Takayama, Schibler, Fenton, Reed: Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. in Cancer research 1993
Show all 7 Pubmed References
Human Monoclonal BCL2 Primary Antibody for IHC (f), IHC (fro) - ABIN967322
Pezzella, Jones, Ralfkiaer, Ersbøll, Gatter, Mason: Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma. in British journal of cancer 1992
Show all 7 Pubmed References
Human Polyclonal BCL2 Primary Antibody for IF (p), IHC (p) - ABIN707156
Wang, Ma, Su: NF-?B pathway contributes to cadmium-induced apoptosis of porcine granulosa cells. in Biological trace element research 2013
Show all 6 Pubmed References
Dog (Canine) Polyclonal BCL2 Primary Antibody for IHC, IHC (p) - ABIN4283360
Chopra, Ray, Dwivedi, Tiwari, Singh, Singh, Kushwaha, Jahan, Pandey, Gupta, Chaturvedi, Pant, Ray, Gupta: Photoprotective efficiency of PLGA-curcumin nanoparticles versus curcumin through the involvement of ERK/AKT pathway under ambient UV-R exposure in HaCaT cell line. in Biomaterials 2016
Show all 6 Pubmed References
Human Monoclonal BCL2 Primary Antibody for IP, IHC - ABIN222984
Cordiali-Fei, Ardigo, Mastroianni, Giuliani, D Agosto, Bordignon, Trento, Vento, Berardesca: Serum cytokines and biohumoral immunological characterization of psoriatic patients in long term etanercept treatment. in International journal of immunopathology and pharmacology 2008
Show all 6 Pubmed References
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
The findings are consistent with rs539846 influencing chronic lymphocytic leukemia (CLL) susceptibility through differential RELA (显示 NFkBP65 抗体) binding, with direct modulation of BMF (显示 BMF 抗体) expression impacting on anti-apoptotic BCL2, a hallmark of oncogenic dependency in CLL.
DR_MOMP delivers a system-based biomarker with significant potential as a prognostic tool for stage III CRC (显示 CALR 抗体) that significantly improves established histopathological risk factors. BCL-2-dependent signalling critically contributed to treatment responses in consensus molecular subtypes 1 and 3, linking for the first time specific molecular subtypes to apoptosis signalling.
Results show that expression level of mTOR (显示 FRAP1 抗体) and BCL2 are regulated by miR497 and provide evidence for their role in the development of TMZ-resistance phenotype of glioma cells.
Data show that MYC (显示 MYC 抗体), BCL2 and BCL6 (显示 BCL6 抗体) translocation had no prognostic impact with respect to progression free survival (PFS) or overall survival (OS).
Interaction of the N-Terminal Tandem Domains of hnRNP (显示 HNRNPC 抗体) LL with the BCL2 Promoter i-Motif DNA Sequence
MYC (显示 MYC 抗体)/BCL2 co-expression is associated with a poorer prognosis and is independent of cell-of-origin classification in diffuse large B-cell lymphoma in the CNS.
These findings provide new insights into MCL-1 (显示 MCL1 抗体) ligands, and the interplay between DRP-1 (显示 CRMP1 抗体) and the anti-apoptotic BCL-2 family members in the regulation of apoptosis
Our findings suggest that the molecular machinery and mechanisms for executing Bcl-2-mediated apoptosis as observed in mammals are evolutionary ancient, with early regulation of apoptotic machineries closely resembling their modern counterparts in mammals rather than Caenorhabditis elegans or drosophila.
Clinical utility for selective inhibition of specific anti-apoptotic Bcl-2 family proteins has recently been realized with the Food and Drug Administration (FDA) approval of venetoclax (formerly ABT-199/GDC (显示 SLC25A16 抗体)-0199) in relapsed chronic lymphocytic leukemia (CLL) with 17p deletion.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (显示 TP53 抗体) and FoxO (显示 FOXO3 抗体) transcription factors and then their target genes Bcl-2, Bim (显示 BCL2L11 抗体), Puma (显示 BBC3 抗体), PERP (显示 PERP 抗体), and MDM2 (显示 MDM2 抗体), without affecting Noxa (显示 PMAIP1 抗体) gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (显示 ANKRD1 抗体) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
This study provides evidence from transgenic mouse models that Crebbp (显示 CREBBP 抗体) deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.
an essential role for the binding of BCL2 to BIM (显示 BCL2L11 抗体) in the survival of noncycling NK cells.
LIGHT signalling pathway combined with IFN-gamma (显示 IFNG 抗体) induces beta cells apoptosis via an NF-kappaB (显示 NFKB1 抗体)/Bcl2-dependent mitochondrial pathway.
Bcl-2 was highly expressed in tubulointerstitial infiltrates in (NZB x NZW)F1 (NZB/NZW) lupus-prone mice.
The abnormal expression of epidermal cytokeratins suggests that Ha-Ras and Bcl-2 suppress the terminal differentiation and sustain the stem cell-like features in epidermal keratinocytes
the augmentation of endogenous MTA1 (显示 MTA1 抗体) expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha (显示 ESR1 抗体) and BCL2 pathways.
These results suggest a role for mitochondrial p53 (显示 TP53 抗体) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (显示 BAX 抗体) and Bcl2.
Zebrafish gene expressions of P53 (显示 TP53 抗体), Bcl-2, Bax (显示 BAX 抗体) and caspase-3 (显示 CASP3 抗体) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (显示 S1PR1 抗体), and ICAM1 (显示 ICAM1 抗体) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 (显示 COX2 抗体) and bcl2, but increased p53 (显示 TP53 抗体) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (显示 NOTCH1 抗体) and fish bcl-2, indicating synergy between the Notch (显示 NOTCH1 抗体) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (显示 STC1 抗体) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (显示 CASP3 抗体) production in the damaged cells. Findings from this study suggest that STC-1 (显示 STC1 抗体) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (显示 BAX 抗体) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (显示 FLT1 抗体) in Bcl-2 expression
apoptosis-inducing factor (显示 AIFM1 抗体) was expressed in luminal alveolar cells and, in concert with a change in bax (显示 BAX 抗体) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (显示 BAX 抗体), Bcl-2, caspase-3 (显示 CASP3 抗体) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (显示 BAX 抗体) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (显示 BAX 抗体)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (显示 CASP3 抗体) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax (显示 BAX 抗体) ratio through a mechanism involving protein kinase C (显示 PKC 抗体).
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (显示 BAX 抗体) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (显示 BAX 抗体).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (显示 TP53 抗体) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (显示 CASP3 抗体).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2