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This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (显示 MAP3K1 ELISA试剂盒)-p38 (显示 MAPK14 ELISA试剂盒), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
this study demonstrates that CPEB2 (显示 CPEB2 ELISA试剂盒) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
there is a decrease in epidermal GDNF and GFRalpha-1 protein expression in normal human skin with ageing
Noxin (显示 C11orf82 ELISA试剂盒) facilitated the expression of Cyclin D1 (显示 CCND1 ELISA试剂盒) and Cyclin E1 (显示 CCNE1 ELISA试剂盒) through activating P38 (显示 CRK ELISA试剂盒)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
In SOD1 (显示 SOD1 ELISA试剂盒)(G93A) spinal cords, we verified a strict correlation in the expression of the TNFalpha (显示 TNF ELISA试剂盒), TNFR1 (显示 TNFRSF1A ELISA试剂盒) and GDNF triad at different stages of disease progression. Yet, ablation of TNFR1 (显示 TNFRSF1A ELISA试剂盒) completely abolished GDNF rises in both SOD1 (显示 SOD1 ELISA试剂盒)(G93A) astrocytes and spinal cords, a condition that accelerated motor neuron degeneration (显示 CLN8 ELISA试剂盒) and disease progression
In functional dyspepsia patients, duodenal expression of GDNF protein was significantly increased compared with controls. GDNF was localized in enteric glial cells, eosinophils, and epithelial cells.
these observations suggest that CD99 (显示 CD99 ELISA试剂盒) is involved in the regulation of CD1a (显示 CD1A ELISA试剂盒) transcription and expression by increasing ATF-2.
Suppression of miR-383 may increase the therapeutic potential of human bone-marrow-derived MSCs in treating spinal cord injury via augmentation of GDNF protein levels.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (显示 TNF ELISA试剂盒) induces the binding of ATF2 to the TNF (显示 TNF ELISA试剂盒)-responsive element.
Our results suggest that GDNF rs3096140 might be involved in the genetic background of smoking, independent of anxiety characteristics.
adiponectin (显示 ADIPOQ ELISA试剂盒) inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (显示 PRKAA1 ELISA试剂盒)/PPARalpha (显示 PPARA ELISA试剂盒)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (显示 MAPK14 ELISA试剂盒), AAT, signal transducer and activator of transcription 1 (STAT1 (显示 STAT1 ELISA试剂盒)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (显示 PRKCE ELISA试剂盒) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (显示 FUK ELISA试剂盒) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (显示 MAPK8 ELISA试剂盒) requires ATF2.
Taken together, our observations indicated that SOCS2 (显示 SOCS2 ELISA试剂盒) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (显示 MAPK14 ELISA试剂盒) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (显示 ATF3 ELISA试剂盒) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (显示 TH ELISA试剂盒) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (显示 IL1B ELISA试剂盒)-induced increase in intestinal tight junction permeability was regulated by p38 (显示 CRK ELISA试剂盒) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (显示 MYLK ELISA试剂盒) gene activity
The ATF2 represses renin (显示 REN ELISA试剂盒) expression by drifting the transcriptional control of renin (显示 REN ELISA试剂盒) gene away from CRE-binding protein (CREB (显示 CREB1 ELISA试剂盒)).
ATF2-based luciferase reporter to monitor non-canonical Wnt (显示 WNT2 ELISA试剂盒) signaling in Xenopus embryos.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR (显示 UTS2R ELISA试剂盒) of ATF1 (显示 AFT1 ELISA试剂盒)/2, and indicates a difference between short and long isoforms.
Ang II (显示 AGT ELISA试剂盒) increases endothelial arginase activity/expression through a p38 MAPK (显示 MAPK14 ELISA试剂盒)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (显示 GRIN2A ELISA试剂盒) protein kinase D (显示 PRKD1 ELISA试剂盒) mutant increased AngII-induced CREB (显示 CREB1 ELISA试剂盒) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (显示 CREB1 ELISA试剂盒) binding to the steroidogenic acute regulatory protein (显示 STAR ELISA试剂盒) promoter.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1