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Human LUM Protein expressed in Wheat germ - ABIN1309888
Littlechild, Zhang, Tomich, Conrad: Fibrinogen, riboflavin, and UVA to immobilize a corneal flap--molecular mechanisms. in Investigative ophthalmology & visual science 2012
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temporal expression of LUM mRNA during dermal wound repair in the horse
the role of lumican in the development of axial myopia
Cancer-associated fibroblast-derived Lumican contributes to tumorigenesis and metastasis of gastric cancer
Lumican and versican (显示 Vcan 蛋白) protein expression are associated with colorectal adenoma-to-carcinoma progression
Lumican is downregulated in the process of scar formation and alleviates hypertrophic scarring by suppressing integrin-FAK (显示 PTK2 蛋白) signaling.
ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera
Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (显示 BGN 蛋白) (p = 0.0008) and Lumican (p = 0.01) and lower expression of Decorin (显示 DCN 蛋白) (p < 0.0001) in urothelial carcinoma of bladder
analysis of decorin (显示 DCN 蛋白) and lumican expression in fibroblasts correlated with palmoplantar collagen bundle size
fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha (显示 TNF 蛋白) secrete the small leucine-rich proteoglycan (显示 Vcan 蛋白) lumican.
This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia.
The results suggest that regions within LUM is associated with ACL (显示 ACLY 蛋白) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.
meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers
this study shows that Lum negatively regulates encephalitic TH17 cells, implicating a potential therapeutic pathway in TH17 cell mediated autoimmune and inflammatory diseases
alternations of lumican might be implicated in the pathogenesis of cardiac fibrosis
LUM may coordinate multiple factors of collagen assembly in the murine heart.
Lumican and biglycan (显示 BGN 蛋白) influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.
Alterations in glycosylated lumican core protein might be implicated in myocardial remodeling and reverse remodeling, with a potential important role for CS/DS GAG chain-synthesizing enzymes.
pro-inflammatory cytokine TNF-alpha (显示 TNF 蛋白) was comparably low 24 hours after infection, but significantly higher in the Lum(-/-) compared to Lum(+/-) infected corneas by 2-5 days after infection
lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression
To investigate the functional role of lumican in hepatic fibrosis, lumican null (Null) and wild-type (WT) littermates were administered carbon tetrachloride intra-peritoneally. Hepatic fibrosis was greatly reduced in null animals.
lumican has a major protective role in gram-negative bacterial infections, a novel function for small leucine-rich repeat proteoglycans.
These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants.
FGF-2 (显示 FGF2 蛋白)- and TGF-beta1 (显示 TGFB1 蛋白)-activation of JNK (显示 MAPK8 蛋白) signaling pathway may be partly responsible for the downregulation of keratocan (显示 KERA 蛋白) and lumican expression in activated corneal keratocytes observed during corneal stromal wound healing.
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
, Keratan sulfate proteoglycan lumican
, KSPG lumican
, keratan sulfate proteoglycan lumican
, lumican proteoglycan
, corneal keratan sulfate proteoglycan 37B core protein
, keratan sulfate proteoglycan