Lumican 蛋白 (LUM)产品概述

Full name:
Lumican 蛋白 (LUM)
在www.antibodies-online.cn可供19 Lumican (LUM) 蛋白的10不同的供货商。 再加上,我们可以发Lumican 抗体 (83)Lumican 试剂盒 (38)和数多这个蛋白质的别的产品。 总共149 Lumican产品已列进来了。
DKFZp468L1116, Ldc, MGC64527, SLRR2D, zgc:86661
列出全部蛋白 基因 基因ID UniProt
LUM 4060 P51884
LUM 17022 P51885
LUM 81682 P51886


按照种类Lumican 蛋白 (LUM)


引用最多的Lumican 蛋白

  1. Human LUM Protein expressed in Human Cells - ABIN2004465 : Chakravarti, Stallings, SundarRaj, Cornuet, Hassell: Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. in Genomics 1995 (PubMed)
    Show all 4 references for 2004465

  2. Human LUM Protein expressed in HEK-293 Cells - ABIN2181488 : Onnerfjord, Heathfield, Heinegård: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for 2181488

  3. Human LUM Protein expressed in Wheat germ - ABIN1309888 : Littlechild, Zhang, Tomich, Conrad: Fibrinogen, riboflavin, and UVA to immobilize a corneal flap--molecular mechanisms. in Investigative ophthalmology & visual science 2012 (PubMed)
    Show all 2 references for 1309888


Horse (Equine) Lumican (LUM) interaction partners

  1. temporal expression of LUM mRNA during dermal wound repair in the horse

Zebrafish Lumican (LUM) interaction partners

  1. the role of lumican in the development of axial myopia

Human Lumican (LUM) interaction partners

  1. Cancer-associated fibroblast-derived Lumican contributes to tumorigenesis and metastasis of gastric cancer

  2. Lumican and versican (显示 Vcan 蛋白) protein expression are associated with colorectal adenoma-to-carcinoma progression

  3. Lumican is downregulated in the process of scar formation and alleviates hypertrophic scarring by suppressing integrin-FAK (显示 PTK2 蛋白) signaling.

  4. ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera

  5. Quantitative polymerase chain reaction for messenger RNA expression from tissue specimens revealed significantly higher expression of Biglycan (显示 BGN 蛋白) (p = 0.0008) and Lumican (p = 0.01) and lower expression of Decorin (显示 DCN 蛋白) (p < 0.0001) in urothelial carcinoma of bladder

  6. analysis of decorin (显示 DCN 蛋白) and lumican expression in fibroblasts correlated with palmoplantar collagen bundle size

  7. fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha (显示 TNF 蛋白) secrete the small leucine-rich proteoglycan (显示 Vcan 蛋白) lumican.

  8. This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia.

  9. The results suggest that regions within LUM is associated with ACL (显示 ACLY 蛋白) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.

  10. meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers

Mouse (Murine) Lumican (LUM) interaction partners

  1. this study shows that Lum negatively regulates encephalitic TH17 cells, implicating a potential therapeutic pathway in TH17 cell mediated autoimmune and inflammatory diseases

  2. ectopic mutant lumican (L199P) may induce enlargement of axial lengths and abnormal structures and distributions of collagen fibrils in mouse sclera

  3. alternations of lumican might be implicated in the pathogenesis of cardiac fibrosis

  4. LUM may coordinate multiple factors of collagen assembly in the murine heart.

  5. Lumican and biglycan (显示 BGN 蛋白) influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.

  6. Alterations in glycosylated lumican core protein might be implicated in myocardial remodeling and reverse remodeling, with a potential important role for CS/DS GAG chain-synthesizing enzymes.

  7. pro-inflammatory cytokine TNF-alpha (显示 TNF 蛋白) was comparably low 24 hours after infection, but significantly higher in the Lum(-/-) compared to Lum(+/-) infected corneas by 2-5 days after infection

  8. lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression

  9. To investigate the functional role of lumican in hepatic fibrosis, lumican null (Null) and wild-type (WT) littermates were administered carbon tetrachloride intra-peritoneally. Hepatic fibrosis was greatly reduced in null animals.

  10. lumican has a major protective role in gram-negative bacterial infections, a novel function for small leucine-rich repeat proteoglycans.

Cow (Bovine) Lumican (LUM) interaction partners

  1. These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants.

Rabbit Lumican (LUM) interaction partners

  1. Lumican is downregulated in the process of scar formation and alleviates hypertrophic scarring by suppressing integrin-FAK (显示 PTK2 蛋白) signaling.

  2. FGF-2 (显示 FGF2 蛋白)- and TGF-beta1 (显示 TGFB1 蛋白)-activation of JNK (显示 MAPK8 蛋白) signaling pathway may be partly responsible for the downregulation of keratocan (显示 KERA 蛋白) and lumican expression in activated corneal keratocytes observed during corneal stromal wound healing.

蛋白简介Lumican (LUM)


This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

Alternative names and synonyms associated with Lumican (LUM)

  • lumican (LUM)
  • lumican (lum)
  • lumican (CpipJ_CPIJ010209)
  • lumican (Lum)
  • DKFZp468L1116 蛋白
  • Ldc 蛋白
  • MGC64527 蛋白
  • SLRR2D 蛋白
  • zgc:86661 蛋白

Protein level used designations for Lumican 蛋白 (LUM)

lumican , zlum , Keratan sulfate proteoglycan lumican , KSPG lumican , keratan sulfate proteoglycan lumican , lumican proteoglycan , KSPG , corneal keratan sulfate proteoglycan 37B core protein , keratan sulfate proteoglycan

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