Use your antibodies-online credentials, if available.
Select your species
Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C (显示 PLC ELISA试剂盒) gamma1 (PLCgamma1 (显示 PLCG1 ELISA试剂盒)) in osteogenesis and PLCgamma2 (显示 PLCG2 ELISA试剂盒) in adipogenesis.
AKT (显示 AKT1 ELISA试剂盒) and 14-3-3 (显示 YWHAQ ELISA试剂盒) proteins down-regulate the activity of several BCR (显示 BCR ELISA试剂盒)-associated components, including BTK (显示 BTK ELISA试剂盒), BLNK (显示 BLNK ELISA试剂盒) and SYK and also inhibit SYK's interaction with Importin 7 (显示 IPO7 ELISA试剂盒)
Expression of SYK and its splice variants was significantly lower in tumors with MSI, and in KRAS wild type, BRAF mutant and PTEN mutant tumors
combined use of butyrate and highly specific Syk inhibitor BAY61-3606 does not enhance differentiation and apoptosis of colonocytes. Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2 (显示 MAPK1/3 ELISA试剂盒)-dependent manner.
Study demonstrates that redundant complexes formed by the mutant SYK(Y3F) protein allow it to maintain signaling to receptor-proximal interaction partners, resulting in proper initiation of BCR (显示 BCR ELISA试剂盒)-proximal signals.
The study identified the criteria for the design of binders that specifically address either the Syk or the Zap-70 (显示 ZAP70 ELISA试剂盒) Tandem Src (显示 SRC ELISA试剂盒) Homology 2 Domains, tSH2 (显示 tshz2 ELISA试剂盒). While Syk tSH2 (显示 tshz2 ELISA试剂盒) has a rather broad substrate scope, ZAP-70 (显示 ZAP70 ELISA试剂盒) tSH2 (显示 tshz2 ELISA试剂盒) required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
SYK mediates the actions of EPO (显示 EPO ELISA试剂盒) and GM-CSF (显示 CSF2 ELISA试剂盒) and coordinates with TGF-beta (显示 TGFB1 ELISA试剂盒) in erythropoiesis.
study demonstrates that high SYK expression is a common feature of CD21 (显示 CR2 ELISA试剂盒)(low) B cells independent of the underlying disorder, and that this high expression is sufficient to drive constitutive phosphorylation of SYK and its immediate targets Bruton's tyrosine kinase (显示 BTK ELISA试剂盒) and phospholipase Cgamma2
IgG (mAb)-opsonized, inactivated Francisella tularensis LVS enhances macrophage and dendritic cell IL-1beta (显示 IL1B ELISA试剂盒) responses in a TLR2 (显示 TLR2 ELISA试剂盒)- and FcgammaR-dependent fashion. FcgammaR-mediated Syk activation leads to NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome-dependent IL-1beta (显示 IL1B ELISA试剂盒) production in macrophages.
High SYK expression is associated with lymphangioleiomyomatosis.
SYK could induce HO-1 (显示 HMOX1 ELISA试剂盒) expression by regulating the Akt (显示 AKT1 ELISA试剂盒) phosphorylation level in H9c2 with A/H injury, protecting H9c2 from the injury induced by A/H treatment.
identified both Syk and Src (显示 SRC ELISA试剂盒) signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
These results identify Syk as a critical component of skin inflammation in a mouse model of epidermolysis bullosa acquisita
Syk was identified as the target enzyme most strongly inhibited by water extract of Cordyceps bassiana.
The downmodulation of Syk expression and phosphorylation in intestinal DCs could be important mechanisms through which helminths induce regulatory DCs that limit colitis.
ephrin B3 (显示 EFNB3 ELISA试剂盒)/EphB2 (显示 EPHB2 ELISA试剂盒) are obvious candidates for driving the Syk-dependent repulsive response.
The effect of Smad4 (显示 SMAD4 ELISA试剂盒) was at least partially mediated by the downstream effectors Syk and ROCK2 (显示 ROCK2 ELISA试剂盒) transcription in megakaryocytes.
These data suggest that Syk mRNA expression dynamics is closely related to bovine leukemia virus-induced disease.
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Tyrosine-protein kinase SYK
, tyrosine-protein kinase SYK
, protein-tyrosine kinase