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抗Human SPRY2 抗体:
抗Mouse (Murine) SPRY2 抗体:
抗Rat (Rattus) SPRY2 抗体:
Human Monoclonal SPRY2 Primary Antibody for IF, IHC (p) - ABIN564439
Barbáchano, Ordóñez-Morán, García, Sánchez, Pereira, Larriba, Martínez, Hernández, Landolfi, Bonilla, Pálmer, Rojas, Muñoz: SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. in Oncogene 2010
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Cow (Bovine) Polyclonal SPRY2 Primary Antibody for WB - ABIN2784218
Hsu, Lee, Hartstein, Harocopos: Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis. in Cornea 2008
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Human Polyclonal SPRY2 Primary Antibody for ELISA, WB - ABIN1043910
August: Cerebrovascular and carotid artery disease. in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2001
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Cow (Bovine) Polyclonal SPRY2 Primary Antibody for IHC, WB - ABIN2784217
Lee, Ho, Roy, Kosinski, Patil, Tward, Fridlyand, Chen: Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. in Hepatology (Baltimore, Md.) 2008
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Human Polyclonal SPRY2 Primary Antibody for ELISA, ICC - ABIN4355751
Zhang, Chaturvedi, Jaggar, Magnuson, Lee, Patel: Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. in Arteriosclerosis, thrombosis, and vascular biology 2005
Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.
Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (显示 MAPK1 抗体) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.
these results establish SPRY2 as a critical negative regulator of BCR (显示 BCR 抗体)-mediated MAPK-Erk (显示 MAPK1 抗体) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.
spry2 can inhibit MM cell growth and survival with a concomitant reduction in phosphorylation of extracellular signal-regulated kinases 1 and 2 in vitro and in vivo.
data suggest that Spry2 acts as a scaffold to bring more pVHL (显示 VHL 抗体)/associated E3 ligase in proximity of HIF1alpha (显示 HIF1A 抗体) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.
MiR (显示 MLXIP 抗体)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (显示 MLXIP 抗体)-122 promotes renal cell carcinoma (显示 MOK 抗体) cell proliferation, migration, and invasion.
miR27b promotes the migration and invasion of gastric cancer cells via inhibition of SPRY2mediated ERK (显示 EPHB2 抗体) signaling.
Arg119Trp variant in the SPRY2 gene was identified as the probable IgA nephropathy-causing mutation. This variant is responsible for inhibition of the MAPK (显示 MAPK1 抗体)/ERK1/2 (显示 MAPK1/3 抗体) pathway.
SPRY2, counter to its roles in other cancer settings, promotes glioma cell and tumor growth and cellular resistance to targeted inhibitors of oncogenic RTKs
Data show that proto-oncogene (显示 RAB1A 抗体) protein B (显示 LEPREL2 抗体)-raf (BRAF (显示 BRAF 抗体)) inhibition induces c-Jun N-terminal kinase (c-JUN) expression and c-JUN (显示 JUN 抗体) abundance and activation by down-regulating SPRY2/4 protein expression.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
The purpose of this study was to determine whether SPRY2 might have antiinflammatory effects on rheumatoid arthritis fibroblast-like synoviocytes.
In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (显示 EPHB2 抗体) signaling.
Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (显示 FGF2 抗体) and EGF (显示 EGF 抗体) stimulation, whereas it diminished proliferation of gingival epithelial cells.
in embryos with lower Spry2;Spry4 (显示 SPRY4 抗体) gene dosages, we observed a non-fusion of original R2 and M1 Shh (显示 SHH 抗体) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud
The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice
Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.
we reveal that SPRY2 expression is regulated by FOXO3a (显示 FOXO3 抗体) and beta-catenin (显示 CTNNB1 抗体) nuclear activity in colon cancer
Spry1 (显示 SPRY1 抗体) and Spry2 coordination is required for normal development of the external genitalia in mice
We propose that Sprouty genes(Spry2 and Spry4 (显示 SPRY4 抗体)) were implicated during evolution in reduction of the cheek teeth in Muridae, and their deletion can reveal ancestral stages of murine dental evolution.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.
protein sprouty homolog 2
, sprouty 2