anti-SPRY2 (SPRY2) 抗体产品概述

Full name:
anti-Sprouty Homolog 2 (Drosophila) 抗体 (SPRY2)
在www.antibodies-online.cn可供75 Sprouty Homolog 2 (Drosophila) (SPRY2) 抗体的13不同的供货商。 再加上,我们可以发SPRY2 蛋白 (13)和数多这个蛋白质的别的产品。 总共92 SPRY2产品已列进来了。
别名:
hSPRY2, sprouty-2, sprouty2, wu:fk66h11, wu:fk93e11, Xsprouty2, xspry2, Xtsprouty2, zgc:110440
列出全部抗体 基因 基因ID UniProt
SPRY2 10253 O43597
SPRY2 24064 Q9QXV8
SPRY2 306141  

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引用最多的anti-SPRY2 抗体

  1. Human Monoclonal SPRY2 Primary Antibody for IF, IHC (p) - ABIN564439 : Barbáchano, Ordóñez-Morán, García, Sánchez, Pereira, Larriba, Martínez, Hernández, Landolfi, Bonilla, Pálmer, Rojas, Muñoz: SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. in Oncogene 2010 (PubMed)
    Show all 3 references for 564439

  2. Cow (Bovine) Polyclonal SPRY2 Primary Antibody for IHC, WB - ABIN2784217 : Hsu, Lee, Hartstein, Harocopos: Clostridium perfringens Keratitis Leading to Blinding Panophthalmitis. in Cornea 2008 (PubMed)
    Show all 2 references for 2784217

  3. Human Polyclonal SPRY2 Primary Antibody for ELISA, WB - ABIN1043910 : August: Cerebrovascular and carotid artery disease. in Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2001 (PubMed)
    Show all 2 references for 1043910

  4. Cow (Bovine) Polyclonal SPRY2 Primary Antibody for WB - ABIN2784218 : Lee, Ho, Roy, Kosinski, Patil, Tward, Fridlyand, Chen: Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 references for 2784218

  5. Human Polyclonal SPRY2 Primary Antibody for ELISA, ICC - ABIN4355751 : Zhang, Chaturvedi, Jaggar, Magnuson, Lee, Patel: Regulation of vascular smooth muscle cell proliferation and migration by human sprouty 2. in Arteriosclerosis, thrombosis, and vascular biology 2005 (PubMed)

更多抗SPRY2的相互作用对抗体

Xenopus laevis Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. Data show that the intracellular domain of PAPC interacts with Sprouty (Spry), and upon binding to PAPC, Spry function is inhibited and PCP signaling is enhanced.

  2. Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of ERK (显示 MAPK1 抗体) activity and thereby contributes to the establishment of dorsoventral patterning during mesoderm formation.

Human Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. upregulated in human CRC (显示 CALR 抗体). Suppression of SPRY2 repressed AKT2 (显示 AKT2 抗体) and EMT (显示 ITK 抗体)-inducing transcription factors and significantly increased E-cadherin (显示 CDH1 抗体) expression. Concurrent downregulation of SPRY1 (显示 SPRY1 抗体) and SPRY2 also increased E-cadherin (显示 CDH1 抗体) and suppressed mesenchymal markers in colon cancer cells.

  2. In cells harbouring a K-Ras (显示 HRAS 抗体) mutation the serine conversion weakens the reduction of migration velocity indicating that dependent on the status of K-Ras (显示 HRAS 抗体) the serine influences Sprouty2 functions differently.

  3. Increased nuclear localization of p21(WAF1/CIP1 (显示 CDKN1A 抗体)) in SPRY2 downregulated colon cancer cells may explain the inhibition of cell proliferation in colon cancer cells.

  4. Data suggest a common mechanism by which DNA methyltransferase1 (DNMT1 (显示 DNMT1 抗体)) and hypoxia inducible factors HIF1alpha (显示 HIF1A 抗体)/HIF2alpha (显示 EPAS1 抗体) regulate Sprouty2 (Spry2) transcription.

  5. We showed that Spry2 is a novel unfolded protein response target and its upregulation is de (显示 EIF2AK3 抗体)pendent on PERK.

  6. has an inhibitory role in TGFbeta (显示 TGFB1 抗体) signaling pathway in lens epithelial cells

  7. these results establish SPRY2 as a critical negative regulator of BCR (显示 BCR 抗体)-mediated MAPK-Erk (显示 MAPK1 抗体) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  8. spry2 can inhibit MM cell growth and survival with a concomitant reduction in phosphorylation of extracellular signal-regulated kinases 1 and 2 in vitro and in vivo.

  9. data suggest that Spry2 acts as a scaffold to bring more pVHL (显示 VHL 抗体)/associated E3 ligase in proximity of HIF1alpha (显示 HIF1A 抗体) and increase its ubiquitylation and degradation. This represents a novel action for Spry2 in modulating biological processes regulated by HIFalpha subunits.

  10. MiR (显示 MLXIP 抗体)-122 could act as a tumor promoter and potentially target Sprouty2. MiR (显示 MLXIP 抗体)-122 promotes renal cell carcinoma (显示 MOK 抗体) cell proliferation, migration, and invasion.

Mouse (Murine) Sprouty Homolog 2 (Drosophila) (SPRY2) interaction partners

  1. Spry2 is a novel unfolded protein response target and its upregulation is dependent on PERK (显示 EIF2AK3 抗体). Knockdown of Spry2 resulted in reduced expression of Serca2 (显示 ATP2A2 抗体), reduced endoplasmic reticulum calcium levels, and induction of the UPR. Spry2 deletion in the adult mouse beta-cell caused hyperglycemia and hypoinsulinemia.

  2. these results establish SPRY2 as a critical negative regulator of BCR (显示 BCR 抗体)-mediated MAPK-Erk (显示 MAPK1 抗体) signaling in chronic lymphocytic leukemia , thereby providing one of the molecular mechanisms to explain the clinical heterogeneity of chronic lymphocytic leukemia.

  3. In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK (显示 EPHB2 抗体) signaling.

  4. Study revealed that suppression of Spry2 expression induced proliferation and differentiation of osteoblastic cells upon bFGF (显示 FGF2 抗体) and EGF (显示 EGF 抗体) stimulation, whereas it diminished proliferation of gingival epithelial cells.

  5. Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer

  6. in embryos with lower Spry2;Spry4 (显示 SPRY4 抗体) gene dosages, we observed a non-fusion of original R2 and M1 Shh (显示 SHH 抗体) signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud

  7. The data showed enhanced axon outgrowth and improved long-distance axon regeneration in sprouty2 deficient mice

  8. Sprouty2 acts as an inhibitor of CrkL-Rap1 signaling.

  9. we reveal that SPRY2 expression is regulated by FOXO3a (显示 FOXO3 抗体) and beta-catenin (显示 CTNNB1 抗体) nuclear activity in colon cancer

  10. Spry1 (显示 SPRY1 抗体) and Spry2 coordination is required for normal development of the external genitalia in mice

SPRY2 抗原简介

Antigen Summary

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Alternative names and synonyms associated with SPRY2

  • sprouty homolog 2 (spry2) 抗体
  • sprouty homolog 2 (Drosophila) (SPRY2) 抗体
  • sprouty homolog 2 (Drosophila) (Spry2) 抗体
  • hSPRY2 抗体
  • sprouty-2 抗体
  • sprouty2 抗体
  • wu:fk66h11 抗体
  • wu:fk93e11 抗体
  • Xsprouty2 抗体
  • xspry2 抗体
  • Xtsprouty2 抗体
  • zgc:110440 抗体

Protein level used designations for SPRY2

protein sprouty homolog 2 , sprouty 2 , spry-2

GENE ID SPECIES
335098 Danio rerio
449471 Xenopus (Silurana) tropicalis
100173576 Pongo abelii
398313 Xenopus laevis
10253 Homo sapiens
485504 Canis lupus familiaris
539090 Bos taurus
24064 Mus musculus
306141 Rattus norvegicus
395584 Gallus gallus
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