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these data support a role for the novel PP2Ac (显示 PPP2CA 抗体)-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity.
CIN85 promotes recycling of TGF-beta (显示 TGFB1 抗体) receptors and thereby positively regulates TGF-beta (显示 TGFB1 抗体) signaling.
we demonstrate that SEPT9 (显示 SEPT9 抗体) negatively regulates EGFR (显示 EGFR 抗体) degradation by preventing the association of the ubiquitin ligase Cbl (显示 CBL 抗体) with CIN85, resulting in reduced EGFR (显示 EGFR 抗体) ubiquitylation
Results support the model that Cbl (显示 CBL 抗体)-CIN85-endophilin complex is not required for efficient internalization of EGFR (显示 EGFR 抗体), a prototype RTK.
Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line.
LOX (显示 LOX 抗体)-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells.
an FRS2beta (显示 FRS3 抗体)-CIN85/CD2AP (显示 Cd2ap 抗体)-Cbl (显示 CBL 抗体) axis for downregulation of ErbB2 (显示 ERBB2 抗体) may regulate ErbB2 (显示 ERBB2 抗体) protein levels in physiological and pathological settings
Data show that EGFR (显示 EGFR 抗体) activation leads to a pronounced src (显示 SRC 抗体)-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR (显示 EGFR 抗体) ubiquitination.
this study indicates that high levels of Ruk(l)/CIN85 contribute to the conversion of breast adenocarcinoma cells into a more malignant phenotype via modulation of the Src (显示 SRC 抗体)/Akt (显示 AKT1 抗体) pathway.
Data show that CIN85 (c-Cbl interacting protein of 85 kDa) is constitutively associated with c-Cbl (显示 CBL 抗体), Cbl-b, and B-cell linker (显示 BLNK 抗体) in B cells.
CIN85/RukL is involved in endocytosis of nephrin (显示 NPHS1 抗体) in podocytes under diabetic conditions, causing podocyte depletion and promoting proteinuria. CIN85/RukL expression therefore shows potential to be a novel target for antiproteinuric therapy in diabetes.
Dab1 (显示 DAB1 抗体) mediated the association of CIN85 with ApoER2 (显示 LRP8 抗体) or VLDLR (显示 VLDLR 抗体) in neurons.
Data suggest that Ser587 Cin85 phosphomimetic mutant protein shows dramatically reduced binding to Dab1 (显示 DAB1 抗体) (disabled protein 1) (without affecting binding to CapZ (显示 CAPZA1 抗体)).
Sh3kbp1 is SUMOylated by SUMO-1 (显示 SUMO1 抗体), -2, and -3 and that SUMOylation is enhanced in the presence of Cd2ap (显示 Cd2ap 抗体).
the interaction between SHIP-1 (显示 INPP5D 抗体) and CIN85 might synergistically facilitate the down-regulation of phosphatidylinositol-3,4,5-trisphosphate levels.
Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 (显示 BLNK 抗体) and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
a B cell-specific deletion of CIN85 led to impaired T cell-independent type II antibody responses in vivo and diminished IKK-beta (显示 IKBKB 抗体) activation and cellular responses to B (显示 TDO2 抗体) cell receptor cross-linking in vitro
Coexpression of CIN85/Ruk(L) with CD2AP (显示 Cd2ap 抗体) led to a decreased binding of CIN85/Ruk(L) to nephrin (显示 NPHS1 抗体) and podocin, which indicates a functional competition between CD2AP (显示 Cd2ap 抗体) and CIN85/Ruk(L).
Data indicate an important function of CIN85 (SH3KBP1) in the regulation of dopamine D2 receptor (显示 DRD2 抗体) functions and provide a molecular explanation for the hyperactive behaviour of CIN85(Deltaex2) mice.
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases
This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.
SH3-domain kinase binding protein 1
, SH3 domain-containing kinase-binding protein 1-like
, CD2-binding protein 3
, SH3 domain-containing kinase-binding protein 1
, Src family kinase-binding protein 1
, c-Cbl-interacting protein
, cbl-interacting protein of 85 kDa
, human Src family kinase-binding protein 1
, migration-inducing gene 18
, src-related kinase binding protein-1
, SH3-containing, expressed in tumorigenic astrocytes
, Sh3 containing, expressed in astrocytes
, regulator of ubiquitous kinase
, SH3 domain-containing adapter protein