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SNHG6 acted as an oncogene (显示 RAB1A ELISA试剂盒) in gastric cancer cells through regulating miR (显示 MLXIP ELISA试剂盒)-101-3p/ZEB1 (显示 ZEB1 ELISA试剂盒) at a post-transcriptional level and silencing expression at a transcriptional level by recruiting enhancer of zeste homolog 2 (EZH2 (显示 EZH2 ELISA试剂盒)) to the promoter of p27 (显示 PAK2 ELISA试剂盒).
PCTAIRE1 (显示 CDK16 ELISA试剂盒) has a role in regulating p27 (显示 PAK2 ELISA试剂盒), c-Myc (显示 MYC ELISA试剂盒) levels and tumor growth in cutaneous cutaneous squamous cell carcinoma cells
Low P27KIP1 expression is associated with Non Small Cell Lung Cancer.
Results show that that Id2 was directly upregulated by BMP4 (显示 BMP4 ELISA试剂盒), resulting in the mediated expression of cell cycle regulatory protein of CDKN1B.
p27 (显示 PAK2 ELISA试剂盒) and its cognate ubiquitin ligases, Skp2/KPC/Pirh2 (显示 RCHY1 ELISA试剂盒), are specifically involved in determining the clinical profiles of lung carcinomas.
In thyroid cancer cells, oncogene (显示 RAB1A ELISA试剂盒) activation prevented TGF-beta (显示 TGFB1 ELISA试剂盒)/SMAD (显示 SMAD1 ELISA试剂盒)-dependent p27 (显示 PAK2 ELISA试剂盒) repression, and CDK2 (显示 CDK2 ELISA试剂盒)/SMAD3 (显示 SMAD3 ELISA试剂盒) phosphorylation, leading to p65 (显示 GORASP1 ELISA试剂盒) NFkappaB (显示 NFKB1 ELISA试剂盒) upregulation which repressed BAX (显示 BAX ELISA试剂盒), induced cyclin D1 (显示 CCND1 ELISA试剂盒) and promoted TGF-beta (显示 TGFB1 ELISA试剂盒)-dependent growth.
PTEN loss and p27 (显示 PAK2 ELISA试剂盒) loss differ among morphologic patterns of prostate cancer.
abnormal levels of Skp2 and p27(KIP1) have probably been involved in the pathogenesis of ADH (显示 AVP ELISA试剂盒) and DCIS. Thus, Skp2 and p27(KIP1) may serve as important diagnosis markers.
Results suggest that interaction of CIB1 with alphaIIb is one of the early events occurring during outside-in signaling. Furthermore, CIB1 recruits FAK to the alphaIIbbeta3 complex at the filopodia where FAK is activated, which in turn activates c-Src, resulting in propagation of outside-in signaling leading to platelet spreading.
Cip2a (显示 KIAA1524 ELISA试剂盒) markedly decreased the expression and nuclear localization of p27Kip1 and this is critical for the ability of Cip2a (显示 KIAA1524 ELISA试剂盒) to promote Triple-negative breast cancer progression.
Study reports that p27 normally exerts a negative feedback on p21 expression: p27 directly represses the expression of the transcription factor Pitx2 (显示 PITX2 ELISA试剂盒) which in turn maintains decreased p21 levels. Consequently, in cells lacking p27, de-repression of Pitx2 (显示 PITX2 ELISA试剂盒) causes the up-regulation of p21 showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (显示 PITX2 ELISA试剂盒) and p21.
Fbxo7 (显示 FBXO7 ELISA试剂盒)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (显示 CDK6 ELISA试剂盒) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (显示 FBXO7 ELISA试剂盒) at different stages in T-cell development.
systems-level control of cell cycle arrest by pRB (显示 PGR ELISA试剂盒)-E2F (显示 E2F1 ELISA试剂盒) and p27-CDK (显示 CDK4 ELISA试剂盒) regulation, is reported.
Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53 (显示 TP53 ELISA试剂盒), promotes ovarian tumor development from the benign adenomas of germ cell-deficient (显示 FANCL ELISA试剂盒) ovaries.
p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha (显示 TNF ELISA试剂盒)/nuclear factor-kappa b pathway. T
Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway.
These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3 (显示 GATA3 ELISA试剂盒), and POU4F3 (显示 POU4F3 ELISA试剂盒) as additional therapeutic targets for ATOH1 (显示 ATOH1 ELISA试剂盒)-mediated auditory hair cells regeneration.
Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR (显示 MLXIP ELISA试剂盒)-24 and targeted by the transcription factors FOXO4 (显示 FOXO4 ELISA试剂盒) and AP4 (显示 REPIN1 ELISA试剂盒) in the peroxidasin (Pxdn (显示 PXDN ELISA试剂盒)) mutation-induced eye disorders, such as glaucoma.
These results suggest that fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level
The down-regulation of p27 and the activation of mTOR (显示 FRAP1 ELISA试剂盒) pathway may be involved in miR (显示 MLXIP ELISA试剂盒)-222-induced heart failure and autophagy inhibition.
FoxO1a (显示 FOXO1 ELISA试剂盒) can regulate p27kip nuclear localization
the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.
p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
cyclin-dependent kinase inhibitor 1B
, cyclin-dependent kinase inhibitor 1b (p27, kip1)
, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27
, Cyclin-dependent kinase inhibitor 1B (p27 Kip1)
, Cyclin-dependent kinase inhibitor 1B (p27, Kip1)
, cyclin-dependent kinase inhibitor p27/Kip1
, Cyclin-dependent kinase inhibitor p27
, cyclin-dependent kinase inhibitor 1b, like