CDK4 (CDK4) ELISA试剂盒产品概述

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Cyclin-Dependent Kinase 4 ELISA试剂盒 (CDK4)
在www.antibodies-online.cn可供35 Cyclin-Dependent Kinase 4 (CDK4) ELISA试剂盒的10不同的供货商。 再加上,我们可以发CDK4 抗体 (320)CDK4 蛋白 (41)和数多这个蛋白质的别的产品。 总共409 CDK4产品已列进来了。
别名:
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726

适于 CDK4 相互作用对的更多 ELISA 试剂盒

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (显示 E2F1 ELISA试剂盒) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 inhibitors in breast cancer for the development of more effective combination therapies.

  2. p16 in combination with MDM2 (显示 MDM2 ELISA试剂盒) and CDK4 immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  3. conclude that p16 is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 (显示 MDM2 ELISA试剂盒) and CDK4

  4. CDK4 overexpression is associated with cancer.

  5. High CDK4 expression is associated with Melanoma.

  6. Staining for MDM2 (显示 MDM2 ELISA试剂盒) and CDK4 was noted in 25/56 and 23/56 atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), respectively, giving a sensitivity of 45% and 41% and a specificity of 98% and 92%. Staining was noted exclusively in the nuclei of atypical cells and not in the nuclei of adipocytes. Staining for MDM2 (显示 MDM2 ELISA试剂盒) and CDK4 occurred in 2/125 and 10/117 benign lipomatous lesions, respectively.

  7. Data suggest that CDK4 (cyclin-dependent kinase 4) is degraded by anaphase-promoting complex/cyclosome (APC (显示 APC ELISA试剂盒)/C) during metaphase-anaphase transition while its main regulator, cyclin D1 (显示 CCND1 ELISA试剂盒), remains intact but is sequestered in cytoplasm; CDK4 protein reaccumulates in the following G1 phase and shuttles between nucleus and cytoplasm to facilitate nuclear import of cyclin D1 (显示 CCND1 ELISA试剂盒); without CDK4, cyclin D1 (显示 CCND1 ELISA试剂盒) cannot enter nucleus.

  8. Cdk4 inhibition leads to directing human mesenchymal stem cells to a multipotent neurogenic fate by inactivating Smads-STAT3 (显示 STAT3 ELISA试剂盒) signaling.

  9. Reduced SIRT2 (显示 SIRT2 ELISA试剂盒) expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

  10. older patients with head and neck squamous cell carcinoma and lung cancer have raised serums CDK4 levels, which has the potential to emerge as a biomarker in clinical practice

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (显示 GJA1 ELISA试剂盒) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. PD 0332991 (PD), an FDA (显示 FDA ELISA试剂盒)-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. Cdk4 protein

  3. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (显示 SOD2 ELISA试剂盒).

  4. a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

  5. Our data indicate that Cdk2 (显示 CDK2 ELISA试剂盒) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (显示 CDK1 ELISA试剂盒) inhibitors for cancer therapy.

  6. CDK4 is a critical downstream target of MEN1 (显示 MEN1 ELISA试剂盒)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (显示 CDK2 ELISA试剂盒) is dispensable for tumorigenesis in these neuroendocrine cell types.

  7. Cdk4 and Cdk6 (显示 CDK6 ELISA试剂盒) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (显示 CDK6 ELISA试剂盒) in sequestering INK4 proteins away from Cdk4.

  8. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  9. insulin (显示 INS ELISA试剂盒) activates cyclin D1 (显示 CCND1 ELISA试剂盒)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (显示 KAT2A ELISA试剂盒) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  10. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (显示 MYC ELISA试剂盒) transgenic model of B lymphoma

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (显示 NRF1 ELISA试剂盒) and consequent induction of Tfam (显示 TFAM ELISA试剂盒) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (显示 MRPL12 ELISA试剂盒) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4) Elisa Kit
  • cyclin-dependent kinase 4 (CDK4) Elisa Kit
  • cyclin-dependent kinase 4 (Cdk4) Elisa Kit
  • Cyclin-dependent kinase 4 (Cdk4) Elisa Kit
  • 8-6 Elisa Kit
  • cdk Elisa Kit
  • cdk4 Elisa Kit
  • cdk4/6 Elisa Kit
  • CG5072 Elisa Kit
  • CMM3 Elisa Kit
  • Crk3 Elisa Kit
  • dCdk4 Elisa Kit
  • DmCdk4 Elisa Kit
  • Dmel\\CG5072 Elisa Kit
  • l(2)05428 Elisa Kit
  • l(2)0671 Elisa Kit
  • l(2)k06503 Elisa Kit
  • l(2)s4639 Elisa Kit
  • l(2)sh0671 Elisa Kit
  • Pk53C Elisa Kit
  • Pk?7 Elisa Kit
  • PSK-J3 Elisa Kit
  • xcdk4 Elisa Kit
  • zgc:153726 Elisa Kit

Protein level used designations for CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

GENE ID SPECIES
777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
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