anti-BRCA1 (BRCA1) 抗体产品概述

Full name:
anti-Breast Cancer 1 抗体 (BRCA1)
在www.antibodies-online.cn可供583 Breast Cancer 1 (BRCA1) 抗体的33不同的供货商。 再加上,我们可以发BRCA1 试剂盒 (33)BRCA1 蛋白 (10)和数多这个蛋白质的别的产品。 总共641 BRCA1产品已列进来了。
别名:
BRCA1, brcai, brcc1, BROVCA1, iris, LOC100224649, PNCA4, PPP1R53, pscp, rnf53

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引用最多的anti-BRCA1 抗体

  1. Human Monoclonal BRCA1 Primary Antibody for IHC (p), IP - ABIN445490 : Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. in Breast cancer research : BCR 2001 (PubMed)
    Show all 8 references for 445490

  2. Human Monoclonal BRCA1 Primary Antibody for CyTOF, FACS - ABIN152030 : Okada, Ouchi: Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. in The Journal of biological chemistry 2003 (PubMed)
    Show all 4 references for 152030

  3. Human Monoclonal BRCA1 Primary Antibody for ICC, FACS - ABIN152032 : Martin, Nahas, Tunuguntla, Fike, Gatti: Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 (PubMed)
    Show all 4 references for 152032

  4. Human Monoclonal BRCA1 Primary Antibody for ChIP, ICC - ABIN151868 : Li, Ting, Zheng, Chen, Ziv, Shiloh, Lee, Lee: Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. in Nature 2000 (PubMed)
    Show all 3 references for 151868

  5. Human Polyclonal BRCA1 Primary Antibody for IHC, ELISA - ABIN1532821 : Miki, Swensen, Shattuck-Eidens, Futreal, Harshman, Tavtigian, Liu, Cochran, Bennett, Ding: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 2 references for 1532821

  6. Human Polyclonal BRCA1 Primary Antibody for ELISA, WB - ABIN1532128 : Wilson, Payton, Elliott, Buaas, Cajulis, Grosshans, Ramos, Reese, Slamon, Calzone: Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. in Oncogene 1997 (PubMed)
    Show all 2 references for 1532128

  7. Human Polyclonal BRCA1 Primary Antibody for IP, WB - ABIN318902 : Venkitaraman: Functions of BRCA1 and BRCA2 in the biological response to DNA damage. in Journal of cell science 2001 (PubMed)

  8. Cow (Bovine) Polyclonal BRCA1 Primary Antibody for IHC, WB - ABIN2777874 : Evans, Shenton, Woodward, Lalloo, Howell, Maher: Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family. in BMC cancer 2008 (PubMed)

更多抗BRCA1的相互作用对抗体

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. Genomic instability can be rescued by deletion of Trp53bp1 (显示 TP53BP1 抗体), encoding the DNA damage response factor 53BP1 (显示 TP53BP1 抗体); mice expressing RING-less BRCA1 do not show an increased susceptibility to tumors in the absence of 53BP1 (显示 TP53BP1 抗体); Genomic instability in cells expressing RING-less BRCA1 correlates with loss of BARD1 (显示 BARD1 抗体) and a defect in restart of replication forks after hydroxyurea treatment

  2. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (显示 NFKB1 抗体) signaling.

  3. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  4. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 (显示 CDKN2A 抗体) and a decline of stem cell function, which was rescued by p16 (显示 CDKN2A 抗体) loss.

  5. Brca1-Wwox (显示 WWOX 抗体) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (显示 WWOX 抗体)-sufficient cells

  6. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  7. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  8. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (显示 COBRA1 抗体)-dependent transcription program during mammary gland development.

  9. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  10. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.

  2. This study implicates novel risk loci as well as highlights the clinical utility for retesting BRCA1/2 negative ovarian cancer patients by genomic sequencing and analysis of genes in relevant pathways.

  3. Women with BRCA1/2 mutations show at diagnosis higher peritoneal tumor load and increased frequency of bulky lymph nodes compared to patients without germline BRCA mutations. Primary debulking surgery seems to ensure a longer progression-free survival in women with BRCA wild type genotype compared to neoadjuvant chemotherapy.

  4. Using electrophoretic retardation assay, atomic force microscopy and DNA binding competition assay, the study showed the greatest preference of the BRCA1 DNA-binding domain to cruciform structure, followed by DNA quadruplex, with the weakest affinity to double stranded B-DNA and single stranded DNA.

  5. Sixteen VUS from 51 BRCA1 variants of uncertain significance (VUS) carriers and 28 VUS from 62 BRCA2 (显示 BRCA2 抗体) VUS carriers were analyzed. There was a slight agreement between the two analyses, with a kappa value of 0.14 (95% confidence interval (CI) = -0.34 to 0.62) for the BRCA1 VUS and a kappa value of 0.17 (95% CI = -0.10 to 0.49) for the BRCA2 (显示 BRCA2 抗体) VUS

  6. Study showed that the prevalence of BRCA1/2 germline mutations was 19% in epithelial ovarian cancer, mostly detected in different gene locations. Two novel frameshift mutations were identified, one in BRCA1 and one in BRCA2 (显示 BRCA2 抗体), as well as two large deletions.

  7. This study shows that BRCA mutation carriers could be frequently identified among breast cancer patients with multiple risk factors. Importantly, we established an NGS-based pipeline for BRCA1/2 testing in clinical practice and strongly suggest that breast cancer patients of premier- and moderate-grade risks receive BRCA1/2 mutations testing in China

  8. Studies suggest that people with high risk of breast cancer and negative BRCA1/BRCA2 (显示 BRCA2 抗体) should be tested for PALB2 (显示 PALB2 抗体) mutations.

  9. Even if a BRCA1 mutation is already identified within a family, the presence of early onset breast cancer affected non-carriers hampers accurate risk estimates for both mutation carriers and other negative family members.

  10. polygenic risk scores may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 抗原简介

Antigen Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1, early onset (BRCA1) 抗体
  • breast cancer 1, early onset (brca1) 抗体
  • breast cancer 1, early onset (LOC100224649) 抗体
  • breast cancer 1, early onset (LOC100347269) 抗体
  • breast cancer 1 (Brca1) 抗体
  • breast cancer 1, early onset (Brca1) 抗体
  • BRCA1 抗体
  • brcai 抗体
  • brcc1 抗体
  • BROVCA1 抗体
  • iris 抗体
  • LOC100224649 抗体
  • PNCA4 抗体
  • PPP1R53 抗体
  • pscp 抗体
  • rnf53 抗体

Protein level used designations for anti-Breast Cancer 1 (BRCA1) 抗体

BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , breast cancer type 1 susceptibility protein homolog , breast cancer 1, early onset , BRCA1 homolog , breast and ovarian cancer susceptibility protein , breast cancer associated 1

GENE ID SPECIES
672 Homo sapiens
353120 Bos taurus
373983 Gallus gallus
403437 Canis lupus familiaris
449497 Pan troglodytes
554178 Monodelphis domestica
712634 Macaca mulatta
733513 Xenopus (Silurana) tropicalis
755086 Strongylocentrotus purpuratus
100049662 Sus scrofa
100051990 Equus caballus
100224649 Taeniopygia guttata
100347269 Oryctolagus cuniculus
12189 Mus musculus
497672 Rattus norvegicus
493761 Felis catus
399391 Xenopus laevis
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