anti-Aurora A (AURKA) 抗体产品概述

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anti-Aurora Kinase A 抗体 (AURKA)
在www.antibodies-online.cn可供288 Aurora Kinase A (AURKA) 抗体的32不同的供货商。 再加上,我们可以发Aurora A 蛋白 (30)Aurora A 试剂盒 (3)和数多这个蛋白质的别的产品。 总共341 Aurora A产品已列进来了。
别名:
87A7-9/2, AIK, AIRK1, ARK-1, Ark1, AU019385, aur-a, AURA, aurka, aurka-a, Aurora-A, AURORA2, AW539821, Ayk1, BTAK, CG3068, ck10, ck[10], Dmel\\CG3068, Eg2, IAK, IAK1, l(3)87Ac, l(3)ck10, pEg2, PPP1R47, Stk6, STK7, STK15, wu:fb37c10, wu:fc02c02, zgc:100912
列出全部抗体 基因 基因ID UniProt
AURKA 6790 O14965
AURKA 20878 P97477
AURKA 261730  

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引用最多的anti-Aurora A 抗体

  1. Human Monoclonal Aurora A Primary Antibody for IF, WB - ABIN393835 : Molli, Li, Bagheri-Yarmand, Pakala, Katayama, Sen, Iyer, Chernoff, Tsai, Nair, Kumar: Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. in The Journal of cell biology 2010 (PubMed)
    Show all 5 references for 393835

  2. Human Polyclonal Aurora A Primary Antibody for ICC, IF - ABIN151735 : Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. in Cancer research 2007 (PubMed)
    Show all 5 references for 151735

  3. Cow (Bovine) Monoclonal Aurora A Primary Antibody for ICC, IF - ABIN151177 : Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. in Molecular and cellular biochemistry 2003 (PubMed)
    Show all 2 references for 151177

  4. Human Polyclonal Aurora A Primary Antibody for ELISA, WB - ABIN184572 : Zhou, Kuang, Zhong, Kuo, Gray, Sahin, Brinkley, Sen: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. in Nature genetics 1998 (PubMed)

  5. Human Polyclonal Aurora A Primary Antibody for IHC (p), WB - ABIN392389 : Kimura, Kotani, Hattori, Sumi, Yoshioka, Todokoro, Okano: Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1. in The Journal of biological chemistry 1997 (PubMed)

  6. Cow (Bovine) Polyclonal Aurora A Primary Antibody for IHC, WB - ABIN2777171 : Ye, Yang, Grossman, Dinney, Wu, Gu: Genetic variants in cell cycle control pathway confer susceptibility to bladder cancer. in Cancer 2008 (PubMed)

  7. Human Polyclonal Aurora A Primary Antibody for IF (p), IHC (p) - ABIN683398 : Ye, Li, Yang, Wang, Hao, Wang, Li, Du, Hao, Liu, Wang, Xia, Huang, Sun, Tian, Fan: Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. in The Journal of experimental medicine 2014 (PubMed)

更多抗Aurora A的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Aurora Kinase A (AURKA) interaction partners

  1. Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.

  2. Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.

  3. AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.

  4. Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.

  5. Drosophila melanogaster aurora A phosphorylates the dynactin (显示 DCTN1 抗体) subunit p150(glued (显示 DCTN1 抗体)) on sites required for its association with the mitotic spindle.

  6. One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (显示 CKAP5 抗体) microtubule-associated protein (显示 FAM82A2 抗体) may be recruited, and thus modulate the behavior of astral microtubules.

  7. Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

  8. Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.

  9. Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (显示 TUBG1 抗体) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.

  10. Aurora-A is essential for many crucial events during mitosis and phosphorylation of a series of substrates by Aurora-A at different stages of mitosis may promote diverse critical events in mitosis to maintain chromosome integrity in cells

Zebrafish Aurora Kinase A (AURKA) interaction partners

  1. Zebrafish Aurora-A is critically required for embryonic proliferation during development.

Human Aurora Kinase A (AURKA) interaction partners

  1. Results provide evidence that AURKA is a target for the VHL (显示 VHL 抗体) E3 ligase ubiquitination.

  2. Results has uncovered a previous unknown positive feedback loop between AURKA and FOXM1 (显示 FOXM1 抗体) that promotes breast cancer stem cells (BCSCs) phenotypes and drug resistance. It showed that nuclear AURKA is recruited by FOXM1 (显示 FOXM1 抗体) to transactivate the expression of target genes, which also include FOXM1 (显示 FOXM1 抗体), whereas AURKA itself is also a downstream transcriptional target of FOXM1 (显示 FOXM1 抗体).

  3. AURKA protein over expression is associated with poor prognosis of malignant melanoma patients.

  4. AURKC (显示 AURKC 抗体) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA rs1047972 and AURKC (显示 AURKC 抗体) rs758099 polymorphisms could affect the risk of GC development.

  5. We propose that the DDR (显示 DDR1 抗体) targets recruitment of Aurora A to the Plk1 (显示 PLK1 抗体)/Bora complex to prevent activation of Plk1 (显示 PLK1 抗体) during DNA damage in G2.

  6. C-A-T haplotypes combined with betel nut chewing lead to a high risk of oral squamous cell carcinoma

  7. TP53-mutated human H (显示 MYC 抗体)CCs revealed inc (显示 TP53 抗体)reased AURKA expression and a positive correlation between AURKA and MYC expression.

  8. This is the first study that links Twist1 (显示 TWIST1 抗体) in a feedback loop with its activating kinase, which indicates that concurrent inhibition of AURKA and Twist1 (显示 TWIST1 抗体) will be synergistic in inhibiting pancreatic tumorigenesis and metastasis.

  9. Aurora A kinases and PP6 (显示 PPP6C 抗体) phosphatases have an ancient function in modulating spindle positioning, thus contributing to faithful cell division.

  10. we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein (显示 TANK 抗体) TIFA (显示 IL22 抗体)

Mouse (Murine) Aurora Kinase A (AURKA) interaction partners

  1. AURKA stabilizes MYC (显示 MYC 抗体) to promote tp53 (显示 TP53 抗体)-altered liver tumor cell survival.

  2. Bcl2l10 (显示 BCL2L10 抗体), Tpx2 (显示 DAZL 抗体), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (显示 BCL2L10 抗体) was present in the same complex with Tpx2 (显示 DAZL 抗体).

  3. Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (显示 IL6 抗体)/STAT3 (显示 STAT3 抗体) and Aurora kinase A in vitro and in vivo

  4. Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer

  5. Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.

  6. observations revealed that the alteration of PKB-GSK-3beta axis, Plk-1, and Aurora kinase-A expressions in HSPC compartment due to DNA damage response was associated with the proliferative impairment and apoptosis during aplastic anemia.

  7. Augmented expression of Aurora kinase-A and Polo-like kinase-1 (显示 PLK1 抗体) at the lactogenic switch likely mediates the formation of binucleated cells.

  8. Aurora A inhibition causes delocalized clustering of Lck (显示 LCK 抗体) at the immunological synapses and decreases its phosphorylation levels thus indicating Aurora A is required for maintaining Lck (显示 LCK 抗体) active during T-cell activation.

  9. Ndel1 (显示 NDEL1 抗体) acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly.

  10. The Aurora kinase A and c-Myc (显示 MYC 抗体) expression and histone H3 (显示 HIST3H3 抗体) phosphorylation level were comparatively higher in the cranial tumor than the caudal (显示 CAD 抗体).

Cow (Bovine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.

Pig (Porcine) Aurora Kinase A (AURKA) interaction partners

  1. Aurora kinase A is unlikely to be involved in CPEB1 (显示 CPEB1 抗体) activating phosphorylation and cyclin B1 (显示 CCNB1 抗体) mRNA polyadenylation during meiotic maturation of porcine oocytes.

  2. Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis

  3. Aurora A stimulates the protein synthesis and promotes the meiotic resumption.

Xenopus laevis Aurora Kinase A (AURKA) interaction partners

  1. These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.

  2. MCAK (显示 KIF2C 抗体) colocalized with NuMA (显示 NUMA1 抗体) and XMAP215 (显示 CKAP5 抗体) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing

  3. Plx1 (显示 PLK1 抗体) promotes activation of Aurora A, most likely through TPX2.

  4. Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.

  5. Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.

  6. binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A

  7. Results suggest that phosphorylation of maskin (显示 TACC3 抗体) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.

  8. The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.

  9. Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2

  10. The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.

Aurora A (AURKA) 抗原简介

Antigen Summary

The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Aurora A (AURKA)

  • aurora (aur) 抗体
  • aurora kinase A (aurka) 抗体
  • hypothetical protein (Aurora-A) 抗体
  • aurora kinase A (AURKA) 抗体
  • aurora kinase A (Aurka) 抗体
  • 87A7-9/2 抗体
  • AIK 抗体
  • AIRK1 抗体
  • ARK-1 抗体
  • Ark1 抗体
  • AU019385 抗体
  • aur-a 抗体
  • AURA 抗体
  • aurka 抗体
  • aurka-a 抗体
  • Aurora-A 抗体
  • AURORA2 抗体
  • AW539821 抗体
  • Ayk1 抗体
  • BTAK 抗体
  • CG3068 抗体
  • ck10 抗体
  • ck[10] 抗体
  • Dmel\\CG3068 抗体
  • Eg2 抗体
  • IAK 抗体
  • IAK1 抗体
  • l(3)87Ac 抗体
  • l(3)ck10 抗体
  • pEg2 抗体
  • PPP1R47 抗体
  • Stk6 抗体
  • STK7 抗体
  • STK15 抗体
  • wu:fb37c10 抗体
  • wu:fc02c02 抗体
  • zgc:100912 抗体

Protein level used designations for anti-Aurora Kinase A (AURKA) 抗体

A-type aurora kinase , AuroraA , CG3068-PA , aur-PA , aurora A , aurora A kinase , aurora kinase , aurora-A , early-A , fruhe2 , Aurora A , hypothetical protein , aurora kinase A , fb37c10 , fc02c02 , serine/threonine-protein kinase 6 , serine/threonine protein kinase 6 , aurora A kinase protein , serine/threonine-protein kinase 6-like , ARK-1 , Aurora-A kinase , IPL1-related kinase , aurora 2 , aurora-related kinase 1 , aurora/IPL1-like kinase , aurora/IPL1-related kinase 1 , breast tumor-amplified kinase , breast-tumor-amplified kinase , hARK1 , protein phosphatase 1, regulatory subunit 47 , serine/threonine kinase 6 , serine/threonine protein kinase 15 , serine/threonine-protein kinase 15 , serine/threonine-protein kinase aurora-A , aurora family kinase 1 , ipl1- and aurora-related kinase 1 , serine/threonine-protein kinase Ayk1 , ratAurA , Aurora-A , Serine/threonine-protein kinase 6 , aurora kinase A-A , p46Eg265 , pEg2 , serine/threonine-protein kinase 6-A , serine/threonine-protein kinase Eg2 , serine/threonine-protein kinase Eg2-A

GENE ID SPECIES
41446 Drosophila melanogaster
549324 Xenopus (Silurana) tropicalis
7200473 Phaeodactylum tricornutum CCAP 1055/1
428167 Gallus gallus
445246 Danio rerio
469980 Pan troglodytes
698190 Macaca mulatta
100216431 Ovis aries
100303586 Saccoglossus kowalevskii
100398107 Callithrix jacchus
100459866 Pongo abelii
100469600 Ailuropoda melanoleuca
6790 Homo sapiens
20878 Mus musculus
261730 Rattus norvegicus
504437 Bos taurus
485940 Canis lupus familiaris
574063 Sus scrofa
397925 Xenopus laevis
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