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STAT6 抗体 (pTyr641)

STAT6 适用: 小鼠 WB 宿主: 小鼠 Monoclonal J71-773-58-11 unconjugated
产品编号 ABIN967582
发货至: 中国
  • 抗原 See all STAT6 抗体
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    抗原表位
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    pTyr641
    适用
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    小鼠
    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This STAT6 antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    3. Please refer to us for technical protocols.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Phosphorylated Mouse STAT6 (Y641) Peptide
    克隆位点
    J71-773-58-11
    亚型
    IgG1 kappa
    Top Product
    Discover our top product STAT6 Primary Antibody
  • 应用备注
    For western blotting of human samples, Purified Mouse Anti-Human Stat6 (pY641) mAb (clone 18) (ABIN968593) is recommended.
    说明

    Related Products: ABIN967389, ABIN968593

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Hale, Krutzik, Samra, Crane, Nolan: "Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus." in: PLoS ONE, Vol. 4, Issue 8, pp. e6756, (2009) (PubMed).

    Bromberg, Darnell: "The role of STATs in transcriptional control and their impact on cellular function." in: Oncogene, Vol. 19, Issue 21, pp. 2468-73, (2000) (PubMed).

    Dent, Hu-Li, Paul, Staudt: "T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 23, pp. 13823-8, (1998) (PubMed).

    Mikita, Campbell, Wu, Williamson, Schindler: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." in: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, (1996) (PubMed).

    Heim: "The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus." in: European journal of clinical investigation, Vol. 26, Issue 1, pp. 1-12, (1996) (PubMed).

    Quelle, Shimoda, Thierfelder, Fischer, Kim, Ruben, Cleveland, Pierce, Keegan, Nelms: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, (1995) (PubMed).

    Hou, Schindler, Henzel, Ho, Brasseur, McKnight: "An interleukin-4-induced transcription factor: IL-4 Stat." in: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, (1994) (PubMed).

  • 抗原
    STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
    别名
    Stat6 (STAT6 产品)
    别名
    D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6-like antibody, STAT6 antibody, Stat6 antibody, LOC100859543 antibody
    背景
    STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
    The J71-773.58.11 antibody recognizes mouse Stat6 phosphorylated at Y641.
    分子量
    97 kDa
    途径
    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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