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NKX6-1 抗体 (N-Term)

NKX6-1 适用: 人, 小鼠, 大鼠, Pig, 兔, 犬, 马, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN784751
发货至: 中国
  • 抗原 See all NKX6-1 抗体
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    抗原表位
    • 10
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 44
    • 23
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Pig, 兔, 犬, 马, Cow, 斑马鱼
    宿主
    • 37
    • 6
    • 1
    • 1
    克隆类型
    • 39
    • 6
    多克隆
    标记
    • 26
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NKX6-1 antibody is un-conjugated
    应用范围
    • 34
    • 24
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS
    预测反应
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    产品特性
    This is a rabbit polyclonal antibody against NKX6-1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human NKX6-1
    Top Product
    Discover our top product NKX6-1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 367 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    别名
    NKX6-1 (NKX6-1 产品)
    别名
    nkx6a antibody, nkx6.1 antibody, NKX6.1 antibody, NKX6A antibody, zgc:92879 antibody, Nkx6.1 antibody, Nkx61 antibody, Nkx6a antibody, NK6 homeobox 1 antibody, NK6 homeobox 1 L homeolog antibody, nkx6-1 antibody, NKX6-1 antibody, nkx6.1 antibody, nkx6-1.L antibody, Nkx6-1 antibody
    背景
    NKX6-1 is the transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. NKX6-1 is involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3, NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. NKX6-1 belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-300 U66797.1 1-300 301-307 AC096766.3 119394-119400 c 308-676 U66797.1 308-676 677-849 U66798.1 7-179 850-1116 U66799.1 7-273
    Alias Symbols: NKX6.1, NKX6A
    Protein Size: 367
    分子量
    38 kDa
    基因ID
    4825
    NCBI登录号
    NM_006168, NP_006159
    UniProt
    P78426
    途径
    Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
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