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Hla Class I b7 Alpha,hla-B 抗体 (FITC)

ABIN118933 产品详细信息, 供应商: Log in to see

克隆类型 (克隆位点)
单克隆 ()
Flow Cytometry (FACS)
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免疫原 Papain solubilized HLA-B7 antigen.
克隆位点 BB7-1
亚型 IgG1
特异性 This antibody recognises the Human HLA-B7 antigen and does not cross-react with HLA-B27 or other related HLA antigens. It can be used to distinguish true HLA-B27 positives from false HLA-B27 positives (i.e. HLA-B7 positive) in the investigation of such diseases as ankylosing spondylitis and anterior uveitis.
交叉反应 (详细) Species reactivity (expected):Cynomolgus monkey.
Species reactivity (tested):Human.
纯化方法 Affinity Chromatography on Protein G
背景 HLA B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta 2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa. Hundreds of HLA B alleles have been described. The HLA B gene is part of the human HLA complex on chromosome 6 and there are a large number of variant alleles of this gene.Synonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7
基因ID 3106
NCBI登录号 NP_005505
UniProt P01889
应用备注 Flow cytometry: use 10 μL of neat - 1/10 diluted antibody to label 1x10^6 cells in 100 μL whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 0.1 mg/mL
缓冲液 PBS, pH 7.4, 0.09 % Sodium Azide, 1 % BSA
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
 image for anti-Hla Class I b7 Alpha,hla-B 抗体 (FITC) (ABIN118933) ABIN118933 staining of HLA-B7 +ve human peripheral blood lymphocytes
背景 Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Brodsky, Parham, Barnstable, Crumpton, Bodmer: "Monoclonal antibodies for analysis of the HLA system." in: Immunological reviews, Vol. 47, pp. 3-61, 1980 (PubMed).