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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. 再加上，我们可以发Sirtuin 6 蛋白 (21) 和 Sirtuin 6 试剂盒 (16)和数多这个蛋白质的别的产品。
Showing 10 out of 216 products:
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952
Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012
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Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624
Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013
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Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181
Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014
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Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Human Polyclonal SIRT6 Primary Antibody for IF (p), IHC (p) - ABIN712481
Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956
Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012
Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661
Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (显示 PARP1 抗体) and/or Sirt6..physical interaction of HBx and PARP1 (显示 PARP1 抗体) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (显示 ATG5 抗体), LC3B (显示 MAP1LC3B 抗体), LAMP1 (显示 LAMP1 抗体), ABCA1 (显示 ABCA1 抗体), ABCG1 (显示 ABCG1 抗体), and MIRN33. (ATG5 (显示 ATG5 抗体) = autophagy-related protein 5 (显示 CAPS 抗体); LC3B (显示 MAP1LC3B 抗体) = microtubule-associated protein 1 light chain 3 beta (显示 MAP1LC3B 抗体); LAMP1 (显示 LAMP1 抗体) = lysosomal-associated membrane protein 1 (显示 LAMP1 抗体); ABCA1 (显示 ABCA1 抗体)/ABCG1 (显示 ABCG1 抗体) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (显示 HMGB1 抗体) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
positive regulator of aldose reductase (显示 AKR1B1 抗体) expression in U937 and HeLa cells under osmotic stress
these results suggest that SIRT6 enhances cell aggressiveness in PTC (显示 F9 抗体) via BRAF (显示 BRAF 抗体)/ERK (显示 EPHB2 抗体)/Mcl1 (显示 MCL1 抗体) pathway, and thus may be a promising target in the treatment of the disease.
our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6-based personalized therapies in esophageal carcinoma cell patients
SIRT6 promotes deacetylation of a new substrate, residue K18 (显示 KRT18 抗体) of histone H3 (显示 HIST3H3 抗体) (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts.
Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70 (显示 XRCC6 抗体)) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax (显示 BAX 抗体) apoptosis regulator protein (Bax (显示 BAX 抗体)), which finally resulted in Bax (显示 BAX 抗体) mitochondrial translocalization.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (显示 MAS1 抗体)) and management in beef cattle breeding programs.
These data suggest that the function of SIRT6 in the Fabp4 (显示 FABP4 抗体)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (显示 INS 抗体) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (显示 INS 抗体) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.
SIRT6, a sirtuin (显示 SIRT1 抗体) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (显示 ACY1 抗体) activity to SIRT6's various functions
Sirt6 binds to promoters of NKG2D (显示 KLRK1 抗体) ligand genes and regulates the H3K9 and H3K56 acetylation levels
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6