anti-Sirtuin 6 (SIRT6) 抗体

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. 再加上,我们可以发Sirtuin 6 蛋白 (21)Sirtuin 6 试剂盒 (16)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SIRT6 51548 Q8N6T7
SIRT6 50721 P59941
SIRT6 299638  

antibodies-online.cn销售最多的anti-Sirtuin 6 抗体

Showing 10 out of 216 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 ChIP, IP, WB 100 μL Log in to see 24至29个工作日
Cow 非结合性 WB 100 μL Log in to see 24至29个工作日
非结合性 EIA, IHC (p) 0.4 mL Log in to see 29至35个工作日
非结合性 IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma Western blot analysis of SIRT6 Antibody (C-term) (ABIN390181) in mouse stomach tissue lysates (35 µg/lane). SIRT6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 5至8个工作日
非结合性 ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Detection of SIRT6 in MEF lysate using ABIN250952. Western Blot: SIRT6 Antibody [ABIN250952] - WB analysis of SIRT6 in NIH/3T3 cell lysate. 0.1 mL Log in to see 25至31个工作日
非结合性 ICC, IF, WB Detection of SIRT6 in HeLa whole cell lysate using ABIN250956. Immunocytochemistry/Immunofluorescence: SIRT6 Antibody [ABIN250956] - SIRT6 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). 0.1 mL Log in to see 25至31个工作日
非结合性 WB SIRT6 antibody tested by Western blot. HeLa cells nuclear extract (25 μg) probed with SIRT6 antibody (1:1,000). 100 μL Log in to see 23至29个工作日
非结合性 IHC (p), WB Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Mouse Cardiac Muscle Tissue Anti- SIRT6Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Log in to see 26至32个工作日
Biotin IHC (p), WB   100 μL Log in to see 14至17个工作日
非结合性 IF (p), IHC (p), WB   100 μL Log in to see 5至7个工作日

通过反应活性、应用领域、克隆类型和共轭标记 SIRT6 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Sirtuin 6 抗体

  1. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952 : Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012 (PubMed)
    Show all 11 references for 250952

  2. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624 : Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013 (PubMed)
    Show all 2 references for 2779624

  3. Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181 : Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014 (PubMed)
    Show all 2 references for 390181

  4. Human Polyclonal SIRT6 Primary Antibody for EIA, IHC (p) - ABIN358735 : Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003 (PubMed)
    Show all 2 references for 358735

  5. Human Polyclonal SIRT6 Primary Antibody for IF (p), IHC (p) - ABIN712481 : Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014 (PubMed)

  6. Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956 : Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012 (PubMed)

  7. Cow (Bovine) Polyclonal SIRT6 Primary Antibody for WB - ABIN2779625 : Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000 (PubMed)

  8. Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661 : Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013 (PubMed)

更多抗Sirtuin 6的相互作用对抗体

Human Sirtuin 6 (SIRT6) interaction partners

  1. Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.

  2. HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (显示 PARP1 抗体) and/or Sirt6..physical interaction of HBx and PARP1 (显示 PARP1 抗体) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis

  3. Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (显示 ATG5 抗体), LC3B (显示 MAP1LC3B 抗体), LAMP1 (显示 LAMP1 抗体), ABCA1 (显示 ABCA1 抗体), ABCG1 (显示 ABCG1 抗体), and MIRN33. (ATG5 (显示 ATG5 抗体) = autophagy-related protein 5 (显示 CAPS 抗体); LC3B (显示 MAP1LC3B 抗体) = microtubule-associated protein 1 light chain 3 beta (显示 MAP1LC3B 抗体); LAMP1 (显示 LAMP1 抗体) = lysosomal-associated membrane protein 1 (显示 LAMP1 抗体); ABCA1 (显示 ABCA1 抗体)/ABCG1 (显示 ABCG1 抗体) = ATP-binding cassette transporters 1/8)

  4. These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (显示 HMGB1 抗体) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.

  5. In obese patients, the expression of Sirt6 expression is reduced.

  6. positive regulator of aldose reductase (显示 AKR1B1 抗体) expression in U937 and HeLa cells under osmotic stress

  7. these results suggest that SIRT6 enhances cell aggressiveness in PTC (显示 F9 抗体) via BRAF (显示 BRAF 抗体)/ERK (显示 EPHB2 抗体)/Mcl1 (显示 MCL1 抗体) pathway, and thus may be a promising target in the treatment of the disease.

  8. our studies shed insights into the crucial functions of sirtuin 6 in esophageal carcinoma cells and provide evidence supporting sirtuin 6-based personalized therapies in esophageal carcinoma cell patients

  9. SIRT6 promotes deacetylation of a new substrate, residue K18 (显示 KRT18 抗体) of histone H3 (显示 HIST3H3 抗体) (H3K18), and inactivation of SIRT6 in cells leads to H3K18 hyperacetylation and aberrant accumulation of pericentric transcripts.

  10. Data show that the increased acetylation of Ku autoantigen 70kDa (Ku70 (显示 XRCC6 抗体)) in sirtuin 6 protein (SIRT6)-depleted cells disrupt its interaction with Bax (显示 BAX 抗体) apoptosis regulator protein (Bax (显示 BAX 抗体)), which finally resulted in Bax (显示 BAX 抗体) mitochondrial translocalization.

Cow (Bovine) Sirtuin 6 (SIRT6) interaction partners

  1. results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (显示 MAS1 抗体)) and management in beef cattle breeding programs.

Mouse (Murine) Sirtuin 6 (SIRT6) interaction partners

  1. These data suggest that the function of SIRT6 in the Fabp4 (显示 FABP4 抗体)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.

  2. a physiological defects in adult SIRT6-/- mice

  3. In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.

  4. It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.

  5. Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (显示 INS 抗体) resistance in high-fat diet-fed FKO mice.

  6. SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.

  7. Data suggest that expression of Sirt6 in pancreatic beta cells protects against dysfunction (loss of hyperglycemia-induced insulin (显示 INS 抗体) secretion) and apoptosis; Sirt6 appears to protect beta cells against the oxidative stress of diabetes type 2 and of cellular aging.

  8. SIRT6, a sirtuin (显示 SIRT1 抗体) with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.

  9. data indicate that distinct activities of SIRT6 regulate different pathways and that the G60A mutant is a useful tool to study the contribution of defatty-acylase (显示 ACY1 抗体) activity to SIRT6's various functions

  10. Sirt6 binds to promoters of NKG2D (显示 KLRK1 抗体) ligand genes and regulates the H3K9 and H3K56 acetylation levels

Sirtuin 6 (SIRT6) 抗原简介


This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Sirtuin 6 (SIRT6) 抗体

  • sirtuin 6 (sirt6) 抗体
  • sirtuin 6 (SIRT6) 抗体
  • sirtuin 6 (Sirt6) 抗体
  • 2810449N18Rik 抗体
  • AI043036 抗体
  • Sir2l6 抗体

Protein level used designations for anti-Sirtuin 6 (SIRT6) 抗体

sirtuin (silent mating type information regulation 2 homolog) 6 , NAD-dependent deacetylase sirtuin-6 , NAD-dependent protein deacetylase sirtuin-6 , SIR2-like protein 6 , regulatory protein SIR2 homolog 6 , sir2-related protein type 6 , sirtuin type 6

444018 Xenopus laevis
428332 Gallus gallus
51548 Homo sapiens
485045 Canis lupus familiaris
100126274 Sus scrofa
535416 Bos taurus
50721 Mus musculus
299638 Rattus norvegicus
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