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SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. 再加上，我们可以发Sirtuin 6 蛋白 (20) 和 Sirtuin 6 试剂盒 (18)和数多这个蛋白质的别的产品。
Showing 10 out of 218 products:
Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250952
Sundaresan, Vasudevan, Zhong, Kim, Samant, Parekh, Pillai, Ravindra, Gupta, Jeevanandam, Cunningham, Deng, Lombard, Mostoslavsky, Gupta: The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. in Nature medicine 2012
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Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967032
Frye: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. in Biochemical and biophysical research communications 2000
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Human Polyclonal SIRT6 Primary Antibody for IHC - ABIN967033
Dephoure, Zhou, Villén, Beausoleil, Bakalarski, Elledge, Gygi: A quantitative atlas of mitotic phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal SIRT6 Primary Antibody for ELISA - ABIN526804
Grimley, Polyakova, Vamathevan, McKenary, Hayes, Patel, Smith, Bridges, Fosberry, Bhardwaja, Mouzon, Chung, Barrett, Richmond, Modha, Solari: Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NF?B responses. in PLoS ONE 2012
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Cow (Bovine) Polyclonal SIRT6 Primary Antibody for ChIP, IP - ABIN2779624
Wajapeyee, Malonia, Palakurthy, Green: Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. in Genes & development 2013
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Human Polyclonal SIRT6 Primary Antibody for IHC (p), WB - ABIN390181
Wu, Liu, Fu, Liu, Zhou: Direct evidence of sirtuin downregulation in the liver of non-alcoholic fatty liver disease patients. in Annals of clinical and laboratory science 2014
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Human Polyclonal SIRT6 Primary Antibody for ICC, IF - ABIN250956
Benavente, Schnell, Jacobson: Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. in PLoS ONE 2012
Human Polyclonal SIRT6 Primary Antibody for IF (p), IHC (p) - ABIN712481
Thirumurthi, Shen, Xia, LaBaff, Wei, Li, Chang, Chen, Lin, Yu, Hung: MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. in Science signaling 2014
Human Polyclonal SIRT6 Primary Antibody for WB - ABIN2668661
Rajendran, Kidane, Yu, Dashwood, Bisson, Löhr, Ho, Williams, Dashwood: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. in Epigenetics 2013
The expression of SIRT6 was reduced during cellular senescence, whereas enforced SIRT6 expression promoted cell proliferation and antagonized cellular senescence.Furthermore, SIRT6 directly interacted with p27 (显示 PAK2 抗体). Finally, SIRT6 markedly rescued senescence induced by p27 (显示 PAK2 抗体).
Previously unknown reciprocal influence of SIRT6 and HK2 (显示 HK2 抗体) in regulating autophagy driven monocyte differentiation.
our findings describe TRF2 (显示 TERF2 抗体) as a novel SIRT6 substrate and demonstrate that acetylation of TRF2 (显示 TERF2 抗体) plays a crucial role in the regulation of TRF2 (显示 TERF2 抗体) protein stability, thus providing a new route for modulating its expression level during oncogenesis and damage response.
SIRT6 over-expression establishes a condition whereby reconfiguration of the Hexokinase 2 (显示 HK2 抗体) promoter chromatin structure makes it receptive to interaction with MZF1 (显示 ZFP42 抗体)/SIRT6 complex, thereby favouring a regulatory state conducive to diminished transcription
This study demonstrates that CSNK2A1 (显示 CSNK2A1 抗体) and SIRT6 are indicators of poor prognosis for breast carcinomas and that CSNK2A1 (显示 CSNK2A1 抗体)-mediated phosphorylation of SIRT6 might be involved in the progression of breast carcinoma.
Thus, these results reveal that SUMOylation has an important role in regulation of Sirt6 deacetylation on H3K56, as well as its tumor suppressive activity.
HBx increased signs of DNA damage such as accumulation of 8-hydroxy-2'-deoxyguanosine and comet formation, which were reversed by overexpression of PARP1 (显示 PARP1 抗体) and/or Sirt6..physical interaction of HBx and PARP1 (显示 PARP1 抗体) accelerates DNA damage by inhibiting recruitment of the DNA repair complex to the damaged DNA sites, which may lead to the onset of hepatocarcinogenesis
Data suggest, in macrophages, SIRT6 plays role in preventing atherosclerosis by reducing foam cell formation via autophagy-dependent pathway involving regulation of expression of ATG5 (显示 ATG5 抗体), LC3B (显示 MAP1LC3B 抗体), LAMP1 (显示 LAMP1 抗体), ABCA1 (显示 ABCA1 抗体), ABCG1 (显示 ABCG1 抗体), and MIRN33. (ATG5 (显示 ATG5 抗体) = autophagy-related protein 5 (显示 CAPS 抗体); LC3B (显示 MAP1LC3B 抗体) = microtubule-associated protein 1 light chain 3 beta (显示 MAP1LC3B 抗体); LAMP1 (显示 LAMP1 抗体) = lysosomal-associated membrane protein 1 (显示 LAMP1 抗体); ABCA1 (显示 ABCA1 抗体)/ABCG1 (显示 ABCG1 抗体) = ATP-binding cassette transporters 1/8)
These findings reveal a previously unknown role for nasal mucosa steady-state conditions in the control of Sirt6 activity, and provide evidence for a relationship between HMGB1 (显示 HMGB1 抗体) and Sirt6 in chronic rhinosinusitis with nasal polyps (CRSwNP), and promising benefits of glycyrrhetinic acid for CRSwNP patients.
In obese patients, the expression of Sirt6 expression is reduced.
results suggest that some polymorphisms in SIRT6 are associated with production traits and may be used as candidates for marker-assisted selection (MAS (显示 MAS1 抗体)) and management in beef cattle breeding programs.
these data provide compelling evidence that Sirt6 is important for podocyte homeostasis and maintenance of glomerular function
The mice with SIRT6 deficiency in muscle displayed impaired glucose homeostasis and insulin (显示 INS 抗体) sensitivity, attenuated whole body energy expenditure, and weakened exercise performance. Results from both gain- and loss-of-function experiments identify SIRT6 as a physiological regulator of muscle mitochondrial function.
Study investigated the involvement of SIRT6 in adult hippocampal neurogenesis. Mice over-expressing Sirt6 exhibit increased numbers of young neurons and decreased numbers of mature neurons, without affecting glial differentiation.
Sirt6 deletion in macrophages promoted the activation of nuclear factor-kappaB (NF-kappaB (显示 NFKB1 抗体)) and endogenous production of interleukin-6 (显示 IL6 抗体), which led to STAT3 (显示 STAT3 抗体) activation and the positive feedback circuits for NF-kappaB (显示 NFKB1 抗体) stimulation; this cross talk expedited an M1 polarization
These data suggest that the function of SIRT6 in the Fabp4 (显示 FABP4 抗体)-Cre-expressing cells in addition to mature adipocytes plays a critical role in body weight maintenance and metabolic homeostasis.
a physiological defects in adult SIRT6-/- mice
In mouse retinae lacking Sirt6, effectors of glycolytic flux were dramatically increased, leading to upregulation of key intermediates in glycolysis, TCA cycle, and glutaminolysis.
It has been demonstrated that Sirt6 plays a role in tooth root formation, and it was confirmed that SIRT6 is necessary for dental mesenchymal cells differentiation as well as for the development of the tooth root and for eventual tooth eruption.
Fat-specific Sirt6 knockout (FKO) sensitized mice to high-fat diet-induced obesity, which was attributed to adipocyte hypertrophy rather than adipocyte hyperplasia. Fat-specific Sirt6 KO also increased inflammation in the adipose tissue, which may have contributed to insulin (显示 INS 抗体) resistance in high-fat diet-fed FKO mice.
SIRT6 is a primary negative regulation factor in endothelial dysfunction and atherosclerosis development.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.
sirtuin (silent mating type information regulation 2 homolog) 6
, NAD-dependent deacetylase sirtuin-6
, NAD-dependent protein deacetylase sirtuin-6
, SIR2-like protein 6
, regulatory protein SIR2 homolog 6
, sir2-related protein type 6
, sirtuin type 6