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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. 再加上，我们可以发NCF2 蛋白 (12)和数多这个蛋白质的别的产品。
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Human Monoclonal NCF2 Primary Antibody for IF, WB - ABIN968245
Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating in The Journal of biological chemistry 1999
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Human Monoclonal NCF2 Primary Antibody for IF, WB - ABIN968246
Benna, Dang, Gaudry, Fay, Morel, Hakim, Gougerot-Pocidalo: Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways. in The Journal of biological chemistry 1997
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Human Polyclonal NCF2 Primary Antibody for ICC, IF - ABIN4343179
Lomnytska, Becker, Bodin, Olsson, Hellman, Hellström, Mints, Hellman, Auer, Andersson: Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. in British journal of cancer 2011
analysis of NCF2, BCKDHB (显示 BCKDHB 抗体) and BCKDHA (显示 BCKDHA 抗体) in pig
We analyzed the clinical and laboratory findings of CGD (显示 CYBB 抗体) with mutations in the NCF2 gene from amongst our cohort of CGD (显示 CYBB 抗体) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (显示 NCF4 抗体) and p67phox at the phagosomal membrane.
TLR4 (显示 TLR4 抗体)- and TLR2 (显示 TLR2 抗体)-induced IRAK (显示 IRAK1 抗体)-ERK (显示 EPHB2 抗体) pathway cross-talks with p67phox-Nox-2 (显示 CYBB 抗体) for reactive oxygen species generation, thus regulating IL-1beta (显示 IL1B 抗体) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 抗体) subunits p22(phox (显示 CYBA 抗体)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA 抗体)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (显示 DNAJC5 抗体)-Gly-Cys (显示 DNAJC5 抗体) triad in Nox2 (显示 CYBB 抗体) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (显示 DNAJC5 抗体)-Gly-Cys (显示 DNAJC5 抗体). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (显示 NCF4 抗体)/VAV1 (显示 VAV1 抗体)/RAC1 NADPH oxidase (显示 NOX1 抗体) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (显示 AKT1 抗体)-GTP (显示 AK3 抗体)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (显示 NOX1 抗体) Nox2 (显示 CYBB 抗体).
Four novel mutations in the NCF1 (显示 NCF1 抗体), NCF2, and CYBB (显示 CYBB 抗体) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (显示 NOX1 抗体) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (显示 PLA2G2A 抗体) activity, an interaction that could function to terminate the PLA2 (显示 PLA2G2A 抗体)-mediated NOX2 (显示 CYBB 抗体) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (显示 FDXR 抗体) oxidasesubunit (67kDa (显示 RPSA 抗体)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (显示 CYBB 抗体)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (显示 SLC2A4 抗体)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (显示 ROS1 抗体) from NADPH oxidase (显示 NOX1 抗体) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (显示 PKCd 抗体)- and ERK (显示 EPHB2 抗体)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)