anti-Neutrophil Cytosolic Factor 2 (NCF2) 抗体

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. 再加上,我们可以发NCF2 蛋白 (12)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
小鼠 非结合性 IF, WB Western blot analysis of p67 [phox] on a EB1 cell lysate (Human B lymphoblast, Burkitt's lymphoma, ATCC HTB-60). Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the mouse anti-p67 [phox] antibody. Immunofluorescence staining of C3H/10T1/2 cells (Mouse embryonic fibroblasts, ATCC CCL-226). 50 μg Log in to see 24至30个工作日
Cow 非结合性 WB WB Suggested Anti-NCF2 Antibody Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell 100 μL Log in to see 24至29个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Immunofluorescence: p67phox/NOXA2 Antibody [NBP1-82542] - Immunofluorescent staining of human cell line A-431 shows positivity in cytoplasm. Western Blot: p67phox/NOXA2 Antibody [NBP1-82542] - Lane 1: Marker [kDa] 229, 112, 84, 48, 32, 27, 17.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted) 0.1 mL Log in to see 28至35个工作日
非结合性 WB 50 μg Log in to see 29至35个工作日
非结合性 IHC (p), WB Human Spleen, Neutrophils (formalin-fixed, paraffin-embedded) stained with NCF2 antibody ABIN305776 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 29至35个工作日
非结合性 ICC, IF, IHC, IP, WB Immunohistochemistry of paraffin-embedded mouse heart using NCF2 antibody at dilution of 1:100 (400x lens). 100 μL Log in to see 34至38个工作日
非结合性 ICC, IHC, IP, WB 100 μg Log in to see 9至12个工作日
小鼠 非结合性 ICC, IHC, IP, WB 100 μg Log in to see 7至10个工作日
非结合性 IC, IF, IP, IHC, WB Immunofluorescent analysis of p67 phox staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibo Immunohistochemical analysis of p67 phox staining in mouse heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with th 200 μL Log in to see 7至8个工作日
小鼠 非结合性 IHC, WB Immunofluorescence analysis of HeLa cell using NCF2 antibody. Blue: DAPI for nuclear staining. 100 μL Log in to see 7至8个工作日

通过反应活性、应用领域、克隆类型和共轭标记 NCF2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-NCF2 抗体

  1. Human Monoclonal NCF2 Primary Antibody for IF, WB - ABIN968245 : Ago, Nunoi, Ito, Sumimoto: Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby activating in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 968245

  2. Human Polyclonal NCF2 Primary Antibody for ICC, IF - ABIN4343179 : Lomnytska, Becker, Bodin, Olsson, Hellman, Hellström, Mints, Hellman, Auer, Andersson: Differential expression of ANXA6, HSP27, PRDX2, NCF2, and TPM4 during uterine cervix carcinogenesis: diagnostic and prognostic value. in British journal of cancer 2011 (PubMed)


Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. analysis of NCF2, BCKDHB (显示 BCKDHB 抗体) and BCKDHA (显示 BCKDHA 抗体) in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (显示 NCF4 抗体) and p67phox at the phagosomal membrane.

  2. TLR4 (显示 TLR4 抗体)- and TLR2 (显示 TLR2 抗体)-induced IRAK (显示 IRAK1 抗体)-ERK (显示 EPHB2 抗体) pathway cross-talks with p67phox-Nox-2 (显示 CYBB 抗体) for reactive oxygen species generation, thus regulating IL-1beta (显示 IL1B 抗体) transcription and processing in monocytic cells.

  3. Skeletal muscle protein expression of the NADPH oxidase (显示 NOX1 抗体) subunits p22(phox (显示 CYBA 抗体)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (显示 CYBA 抗体)) and p67(phox) expression was attenuated by exercise training in obese subjects.

  4. A novel homozygous mutation in NCF2.

  5. results reveal an essential role for the Cys (显示 DNAJC5 抗体)-Gly-Cys (显示 DNAJC5 抗体) triad in Nox2 (显示 CYBB 抗体) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (显示 DNAJC5 抗体)-Gly-Cys (显示 DNAJC5 抗体). The 2 regions interact with distinct partner sites in p67(phox).

  6. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (显示 NCF4 抗体)/VAV1 (显示 VAV1 抗体)/RAC1 NADPH oxidase (显示 NOX1 抗体) complex.

  7. Data indicate that arachidonic acid induces the direct interaction of Rac (显示 AKT1 抗体)-GTP (显示 AK3 抗体)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (显示 NOX1 抗体) Nox2 (显示 CYBB 抗体).

  8. Four novel mutations in the NCF1 (显示 NCF1 抗体), NCF2, and CYBB (显示 CYBB 抗体) genees have been identified in chronic granulomatous disease patients in Morocco.

  9. Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.

  10. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Just as patients with chronic granulomatous disease who lack NADPH oxidase (显示 NOX1 抗体) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  2. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (显示 PLA2G2A 抗体) activity, an interaction that could function to terminate the PLA2 (显示 PLA2G2A 抗体)-mediated NOX2 (显示 CYBB 抗体) activation signal.

  3. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (显示 FDXR 抗体) oxidasesubunit (67kDa (显示 RPSA 抗体)) and the resultant metabolic oxidative stress.

  4. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (显示 CYBB 抗体)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (显示 SLC2A4 抗体)-/-) mice.

  5. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  6. This study demonstrates the involvement of ROS (显示 ROS1 抗体) from NADPH oxidase (显示 NOX1 抗体) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (显示 PKCd 抗体)- and ERK (显示 EPHB2 抗体)-dependent pathways.

NCF2 抗原简介


This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with NCF2

  • neutrophil cytosolic factor 2 (NCF2) 抗体
  • neutrophil cytosolic factor 2 (ncf2) 抗体
  • neutrophil cytosolic factor 2 (p67phox) 抗体
  • neutrophil cytosol factor 2 (VDBG_06643) 抗体
  • neutrophil cytosolic factor 2 (PGTG_05816) 抗体
  • neutrophil cytosolic factor 2 (LOC100136240) 抗体
  • neutrophil cytosolic factor 2 (Ncf2) 抗体
  • MGC81877 抗体
  • Ncf-2 抗体
  • NOXA2 抗体
  • P67-PHOX 抗体
  • P67PHOX 抗体
  • zgc:158405 抗体

Protein level used designations for NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

424445 Gallus gallus
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457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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