ISG15 Ubiquitin-Like Modifier 蛋白 (ISG15)

The protein encoded by ISG15 is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. 再加上,我们可以发ISG15 抗体 (153)ISG15 试剂盒 (31)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ISG15 9636 P05161
ISG15 100038882 Q64339
大鼠 ISG15 ISG15 298693  
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antibodies-online.cn销售最多的ISG15 蛋白

Showing 10 out of 29 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
大肠杆菌(E. Coli) GST tag ISG15 Ubiquitin-Like Modifier (ISG15) (AA 2-157), (full length) protein (GST tag) 50 μg Log in to see 13至16个工作日
大肠杆菌(E. Coli) 非结合性 1 mg Log in to see 20至21个工作日
大肠杆菌(E. Coli) CaM 100 μg Log in to see 15至19个工作日
大肠杆菌(E. Coli) 小鼠 GST tag   50 μg Log in to see 11 Days
大肠杆菌(E. Coli) His tag   50 μg Log in to see 4 Days
大肠杆菌(E. Coli) His tag   10 μg Log in to see 15至16个工作日
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10至12个工作日

ISG15 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , , , , , , , , ,
Mouse (Murine)
, ,

更多ISG15 Ubiquitin-Like Modifier (ISG15)互动伙伴

Zebrafish ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Overall, these data demonstrate the antiviral effect of a fish ISG15 protein, revealing the conservation among vertebrates of an ISGylation mechanism likely directed against viruses.

Pig (Porcine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. NSP2 (显示 RTN2 蛋白) of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of ISG15.

  2. Results report identification and cloning of the ISG15 and ISG43 (显示 USP18 蛋白) genes in pig.

Human ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. Results suggest that unconjugated ISG15 affects the functions of HCV NS5A through protein-protein interaction.

  2. This report demonstrates that ISG15 induced by Hepatitis E virus replication in Huh7-S10 (显示 L1CAM 蛋白)-3 human liver cells plays an immunomodulatory role by negatively regulating type I Interferon (显示 IFNA 蛋白) signaling and, thus, Hepatitis E virus sensitivity to type I Interferon (显示 IFNA 蛋白).

  3. epletion of either ISG15 or UBE2L6/UBCH8 (显示 UBE2L6 蛋白) resulted in enhanced endogenous autophagic flux.

  4. unlike ISG15, ubiquitin and FAT10 (显示 UBD 蛋白) are conjugated to a similar degree to newly translated and pre-existing proteins.

  5. This paper shows that ISG15 directly regulates Human Cytomegalovirus replication and that its accumulation restricts productive virus growth.

  6. The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.

  7. These data indicate that hepatic expression of PSMA6 (显示 PSMA6 蛋白), which is upregulated during viral hepatitis, likely depends on TLR3 (显示 TLR3 蛋白) activation and, that PSMA6 (显示 PSMA6 蛋白) affects the expression of immunoregulatory ISG15, a proviral factor in the pathogenesis of hepatitis C virus infection.

  8. ISG15 dysregulation may be involved in the pathogenesis of glomerular inflammation

  9. This study shows that interferon (显示 IFNA 蛋白)-stimulated gene 15 (ISG15) lowers Human respiratory syncytial virus growth through protein ISGylation.

  10. Data show the induction of signal transducer and activator of transcription (STAT)1 (显示 STAT1 蛋白) and IFN-stimulated gene 15 protein (ISG15) in Rickettsia conorii-infected human umbilical vein endothelial cells (HUVECs).

Mouse (Murine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. results demonstrate that ISG15 governs the dynamic functionality of mitochondria, specifically, OXPHOS and mitophagy, broadening its physiological role as an antiviral agent.

  2. Loss of ISG15 expression and type I IFN signaling have transient effects on bacterial burden during M. tuberculosis infection in mice

  3. ISG15 acts as an immunomodulator in the cornea and plays a critical role in controlling fungal keratitis.

  4. USP18 (显示 USP18 蛋白)'s ISG15 specificity is mediated by a small interaction interface.

  5. Posttranslational protein modification by ISG15 plays an important role in antiviral defense

  6. These studies provide evidence, ISG15 is elevated following TBI in mice, preceding MLCK elevation, development of BBB disruption, and cerebral edema.

  7. Kruppel-like factor 9 (KLF9 (显示 KLF9 蛋白)) is a haploinsufficient tumor suppressor in the ApcMin/+ mouse colon by suppressing expression of ISG15, an apoptosis-inhibiting cytokine.

  8. Propose that Isg15-dependent degradation of p53 (显示 TP53 蛋白) represents an alternative mechanism of controlling p53 (显示 TP53 蛋白) protein levels, and, thus, it is an attractive pathway for drug discovery.

  9. Embryo mortality occurs in pregnant Isg15(-/-) mice, is exacerbated by environmental insults like maternal hypoxia, and might result from impaired early decidualization, vascular development, and formation of the labyrinth.

  10. Enhanced resistance upon influenza B infection in USP18 (显示 USP18 蛋白)(C61A/C61A (显示 BRCC3 蛋白)) mice was completely reversed in USP18 (显示 USP18 蛋白)(C61A/C61A (显示 BRCC3 蛋白)) mice, which additionally lack ISG15, providing evidence that the observed reduction in viral titers is ISG15 dependent

Cow (Bovine) ISG15 Ubiquitin-Like Modifier (ISG15) interaction partners

  1. ISG 15 gene expression is upregulated during 16-18 days of pregnancy and could be used as an early pregnancy marker in dairy cows, especially in heifers.

  2. ISG15, UBE1l (显示 UBA7 蛋白) and UBCH8 (显示 UBE2E2 蛋白) genes are significantly upregulated in the artificially inseminated pregnant cows.

  3. Data indicate that the expression profiles of ISG15, MX1 (显示 MX1 蛋白), MX2 (显示 MX2 蛋白), and OAS1 (显示 OAS1 蛋白) could be a useful diagnostic biomarker of gestation.

  4. ISG15 is an antiviral and inducible protein in bovine immunodeficiency virus infected bovin lung cells.

  5. ISG15 and conjugated proteins were expressed in corpus luteum of both cyclic and pregnant cows regardless of pregnancy status and were upregulated during early pregnancy

  6. interferon-stimulated protein (显示 ISG20 蛋白)(ISG15) was localized throughout the endometrium on day 18-23 of bovine pregnancy and was specifically localized to organelles and compartments of endometrial epithelial cells and stromal cells

  7. rbovISG15 is unstable over time in storage & dialysis. In vivo, conjugation of ISG15 to targeted proteins occurs inside the cell.



The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.

Gene names and symbols associated with ISG15

  • ISG15 ubiquitin-like modifier (ISG15)
  • ISG15 ubiquitin-like modifier (isg15)
  • ISG15 ubiquitin-like modifier (Isg15)
  • G1p2 蛋白
  • hUCRP 蛋白
  • IFI15 蛋白
  • IGI15 蛋白
  • IP17 蛋白
  • Irfp 蛋白
  • ISG15 蛋白
  • ISG17 蛋白
  • ISG17/UCRP 蛋白
  • si:rp71-1c23.2 蛋白
  • UCRP 蛋白

Protein level used designations for ISG15

interferon, alpha-inducible protein (clone IFI-15K) , interferon-induced 17-kDa/15-kDa protein , interferon-stimulated protein, 15 kDa , ubiquitin cross-reactive protein , ubiquitin-like protein ISG15 , boUCRP , interferon-stimulated gene product 17 , ISG15 ubiquitin-like modifier , si:rp71-1c23.2 , zfISG15 , interferon stimulated gene, 15 kDa , interferon, alpha-inducible protein , interferon-induced 17 kDa protein , interferon-stimulated protein 15 , interferon-induced 15 kDa protein , interferon-induced 15-KDa protein , interferon-stimulated protein (15 kDa) , interferon stimulated gene 17 , interferon-stimulated protein 17/ubiquitin cross-reactive protein

9636 Homo sapiens
281871 Bos taurus
465390 Pan troglodytes
558956 Danio rerio
700141 Macaca mulatta
100145895 Sus scrofa
100174787 Felis catus
100038882 Mus musculus
298693 Rattus norvegicus
100855667 Canis lupus familiaris
100354504 Oryctolagus cuniculus
443057 Ovis aries
102169982 Capra hircus
100066364 Equus caballus
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