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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. 再加上，我们可以发PD-L1 抗体 (366) 和 PD-L1 蛋白 (83)和数多这个蛋白质的别的产品。
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (显示 MLXIP ELISA试剂盒)-155, Pdcd1 (显示 PDCD1 ELISA试剂盒), Pdcd1l1, and Ctla4 (显示 CTLA4 ELISA试剂盒) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 (显示 PDCD1 ELISA试剂盒) = programmed cell death 1 (显示 PDCD1 ELISA试剂盒) protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 (显示 CTLA4 ELISA试剂盒) = cytotoxic T-lymphocyte-associated protein 4 (显示 CTLA4 ELISA试剂盒)]
Expression of LAP/TGF-beta1 (显示 TGFB1 ELISA试剂盒), CD80 (显示 CD80 ELISA试剂盒), CD86 (显示 CD86 ELISA试剂盒) and PD-L1 is significantly increased in tumor-infiltrating B cells (TIL (显示 TLR1 ELISA试剂盒)-B) relative to splenic B cells. LAP/TGF-beta1 (显示 TGFB1 ELISA试剂盒) expression on TIL (显示 TLR1 ELISA试剂盒)-B progressively increased from 5.4+/-1.7% on day 8 to 43.1+/-6.1% by day 21 post tumor implantation.
spleen-derived IFN-gamma (显示 IFNG ELISA试剂盒) induces generation of PD-L1(+)-suppressive neutrophils.
PD-L1 and PD-L2 (显示 PDCD1LG2 ELISA试剂盒) in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.
It was concluded that down-regulated expression of miR (显示 MLXIP ELISA试剂盒)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (显示 MLXIP ELISA试剂盒)-143 or inhibition of B7H1.
HDAC6 (显示 HDAC6 ELISA试剂盒) inhibition reduces tumor growth and PD-L1 production in vivo.
findings indicate that the PerC (显示 PPARGC1B ELISA试剂盒) B cells, including PD-L1/PD-L2 (显示 PDCD1LG2 ELISA试剂盒) B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection
PD-L1 selectively enhances T cell-mediated immune responses, driving graft-versus-host disease lethality and suggesting a context-dependent function of the PD-1 (显示 PDCD1 ELISA试剂盒)/PD-L1 axis
Mesenteric lymph node CD11b (显示 ITGAM ELISA试剂盒)(-) CD103 (显示 ITGAE ELISA试剂盒)(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (显示 TGFB1 ELISA试剂盒) activation.
These results indicate that the outcome of PD-L1-mediated signaling in CD8 (显示 CD8A ELISA试剂盒)+ T cells depends on the presence or absence of CD4 (显示 CD4 ELISA试剂盒)+ T cells, the nature of the interacting receptor expressed by CD8 (显示 CD8A ELISA试剂盒)+ T cells, and the tissue environment in which the signaling occurs.
We identified that there are significant differences between the tumor microenvironment of paired primary lung cancers and brain metastases. When physicians decide to treat patients with lung cancer with a PD-1 (显示 PDCD1 ELISA试剂盒) or PD-L1 inhibitor, they must do so in the context of the spatial and temporal heterogeneity of the tumor microenvironment
High expression of PDL1 is associated with high grade serous ovarian cancer.
The small-molecule interaction "hot spots" on PD-L1 surfaces suggest approaches for the PD-1 (显示 PDCD1 ELISA试剂盒)/PD-L1 antagonist drug discovery.
Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages.
PD-L1 expression was associated with high proliferative activity and the EMT (显示 ITK ELISA试剂盒) phenotype in adenocarcinoma but not in squamous cell carcinoma of the lung. PD-L1 expression was a significant poor prognostic factor in patients with lung adenocarcinoma.
In epithelial ovarian cancer , tumour infiltrating lymphocytes levels are prognostic at diagnosis and remain prognostic after Neoadjuvant chemotherapy. TILs and PD-L1 expression increase following Neoadjuvant chemotherapy.
The data define a unique topology of classical Hodgkin lymphoma in which PD-L1(+) tumor-associated macrophages surround Hodgkin Reed-Sternberg (HRS) cells and implicate CD4 (显示 CD4 ELISA试剂盒)(+) T cells as a target of PD-1 (显示 PDCD1 ELISA试剂盒) blockade.
Data suggest that quantitative PD-L1 mRNA determination should be considered as an alternative to immunohistochemical (IHC) as there is no interobserver variability in RNA results.
Both PD-L1 copy number gains and expression were associated with smoking-related lung tumors and predicted poor prognosis.
This study shows PTEN/PI3K (显示 PIK3CA ELISA试剂盒) pathway and PD-L1 in MPM are frequently activated. Results suggests that there is not association between PD-L1 and the involvement of the PI3K (显示 PIK3CA ELISA试剂盒) pathway in MPM.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (显示 PDCD1 ELISA试剂盒)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (显示 PDCD1LG2 ELISA试剂盒) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1