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The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). 再加上，我们可以发BAP1 蛋白 (7) 和 BAP1 试剂盒 (4)和数多这个蛋白质的别的产品。
Showing 10 out of 126 products:
Human Monoclonal BAP1 Primary Antibody for IF, WB - ABIN1105494
Jensen, Proctor, Marquis, Gardner, Ha, Chodosh, Ishov, Tommerup, Vissing, Sekido, Minna, Borodovsky, Schultz, Wilkinson, Maul, Barlev, Berger, Prendergast, Rauscher: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. in Oncogene 1998
Human Polyclonal BAP1 Primary Antibody for IHC (p), WB - ABIN388948
Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011
Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775
Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (显示 INO80 抗体) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (显示 VHL 抗体) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (显示 VHL 抗体) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (显示 VHL 抗体) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (显示 GJB1 抗体) expression is in part related to induction of tight junctions through modulation of Magi1 (显示 CNKSR3 抗体) expression in an immortalized hepatic cell line.
ARIP1 (显示 MAGI2 抗体) and ARIP2 (显示 SYNJ2BP 抗体) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (显示 HCFC1 抗体) and OGT (显示 OGT 抗体) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Data conclude that the up-regulation of sdk-1 (显示 SDK1 抗体) in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 (显示 CNKSR3 抗体) function.
NEAT-1 is a downstream effector of gemcitabine sensitivity in CCA (显示 FBN2 抗体). The expression of BAP1 (显示 RNF2 抗体) is a determinant of sensitivity to therapeutic drugs that can be exploited to enhance responses through combination strategies.
lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 (显示 FOXO1 抗体) transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1 (显示 RNF2 抗体)) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 (显示 FOXO1 抗体) promoter
Bap1 (显示 RNF2 抗体) is a bona fide tumor suppressor gene and offer key insights into the contribution of carcinogen exposure to enhanced cancer susceptibility
BAP1 (显示 RNF2 抗体) protein as determined by immunohistochemistry was absent in all samples with a BAP1 (显示 RNF2 抗体) mutation irrespective of the functional type of mutation
In two out of six families with both mesothelioma and melanoma identified either a germline nonsense mutation (c.1153C > T, p.Arg385*) in BAP1 (显示 RNF2 抗体) or a recurrent pathogenic germline mutation (c.301G > T, p.Gly101Trp) in CDKN2A (显示 CDKN2A 抗体).
Germline mutations in BAP1 (显示 RNF2 抗体) gene is associated with familial uveal melanoma.
BAP1 (显示 RNF2 抗体) gene deletion is associated with chordoma.
Our study revealed a unique tissue-specific significance of BAP1 (显示 RNF2 抗体) mutation in prognostic prediction among different types of cancer. Clinically, combining detection of BAP1 (显示 RNF2 抗体) mutation and other driver mutations may further allow for a more precise molecular taxonomy to stratify patients into distinct subgroups in uveal melanoma and clear cell renal cell carcinoma (显示 MOK 抗体)
on the basis of our meta-analysis, we have demonstrated a peculiar role of BAP1 (显示 RNF2 抗体) in influencing the prognosis in cancer. Thus, BAP1 (显示 RNF2 抗体) could be considered as an important potential target for personalized medicine.
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX (显示 EIF1AX 抗体)-mutated tumors and tumors without BAP1 (显示 RNF2 抗体), SF3B1 (显示 SF3B2 抗体), or EIF1AX (显示 EIF1AX 抗体) mutations are associated with prolonged survival and low metastatic risk, SF3B1 (显示 SF3B2 抗体)-mutated tumors are associated with late metastasis
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1