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The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). 再加上，我们可以发BAP1 蛋白 (7) 和 BAP1 试剂盒 (4)和数多这个蛋白质的别的产品。
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Human Monoclonal BAP1 Primary Antibody for FACS, WB - ABIN258775
Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010
Human Polyclonal BAP1 Primary Antibody for IHC (p), WB - ABIN388948
Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011
the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (显示 INO80 抗体) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (显示 VHL 抗体) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (显示 VHL 抗体) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (显示 VHL 抗体) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
Cx32 (显示 GJB1 抗体) expression is in part related to induction of tight junctions through modulation of Magi1 (显示 CNKSR3 抗体) expression in an immortalized hepatic cell line.
ARIP1 (显示 MAGI2 抗体) and ARIP2 (显示 SYNJ2BP 抗体) are co-expressed in some nerve cells and their biological activities are distinct.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (显示 HCFC1 抗体) and OGT (显示 OGT 抗体) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
Data conclude that the up-regulation of sdk-1 (显示 SDK1 抗体) in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 (显示 CNKSR3 抗体) function.
Loss of BAP1 (显示 RNF2 抗体) expression is associated with lung adenocarcinoma.
Our data confirm the established role of BAP1 (显示 RNF2 抗体) as a tumor suppressor protein (显示 TP53 抗体) and is the first report where BAP1 (显示 RNF2 抗体) has been studied in pT1 (显示 ZNF77 抗体) clear cell renal cell carcinomas
Important role of BAP1 (显示 RNF2 抗体) in the survival of osteosarcoma cells.
Loss of BAP1 (显示 RNF2 抗体) expression is a rare event in non-small cell lung cancer.
BAP1 (显示 RNF2 抗体) immunohistochemistry has limited prognostic utility as a complement of CDKN2A (p16 (显示 CDKN2A 抗体)) fluorescence in situ hybridization in malignant pleural mesothelioma.
BAP1 (显示 RNF2 抗体) and PBRM1 (显示 PBRM1 抗体) loss is seen frequently in intrahepatic cholangiocarcinoma
BAP1 (显示 RNF2 抗体) loss and high EZH2 (显示 EZH2 抗体) expression were highly specific to malignant mesothelioma in differentiating it from benign mesothelial proliferations
We analyzed the prevalence of germline BAP1 (显示 RNF2 抗体) mutations in a group of asbestos-exposed malignant mesothelioma patients and found non obviously pathogenic germline sequence variants of BAP1 (显示 RNF2 抗体).
NEAT-1 is a downstream effector of gemcitabine sensitivity in CCA (显示 FBN2 抗体). The expression of BAP1 (显示 RNF2 抗体) is a determinant of sensitivity to therapeutic drugs that can be exploited to enhance responses through combination strategies.
lncFOXO1 suppressed the growth of breast cancer by increasing FOXO1 (显示 FOXO1 抗体) transcription. Moreover, we found that lncFOXO1 associated with BRCA-1-associated protein 1 (BAP1 (显示 RNF2 抗体)) and regulates its binding and the level of mono-ubiquitinated H2A at K119 (ubH2AK119) at FOXO1 (显示 FOXO1 抗体) promoter
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
BRCA1-associated protein 1
, ubiquitin C-terminal hydrolase X4
, ubiquitin carboxyl-terminal hydrolase BAP1
, cerebral protein 6
, cerebral protein-13
, Brca1 associated protein 1
, BAI1-associated protein 3
, ubiquitin carboxy-terminal hydrolase
, BAI1-associated protein 1
, guanylate kinase membrane-associated inverted 1
, membrane-associated guanylate kinase inverted 1
, membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1