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Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa (显示 FLVCR1 ELISA试剂盒)) by regulating both androgen receptor (AR (显示 AR ELISA试剂盒)) and Notch (显示 NOTCH1 ELISA试剂盒) signaling pathway.
results indicate that Aes may belong to a novel family of metastasis su (显示 YY2 ELISA试剂盒)ppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally
heat shock cognate 70 (HSC70 (显示 HSPA8 ELISA试剂盒)) is an essential component of Aes foci in colorectal cancer cells.
AES is a transcriptional repressor for HNF-1-alpha (显示 HNF1A ELISA试剂盒) in pancreatic beta-cell.
AES binds to PROP1 (显示 PROP1 ELISA试剂盒) and represses its expression; PROP1 (显示 PROP1 ELISA试剂盒) mutation is a likely cause of combined pituitary hormone (显示 CGA ELISA试剂盒) deficiency.
GRG5/AES interacts with TCF4 (显示 TCF4 ELISA试剂盒) and represses Wnt (显示 WNT2 ELISA试剂盒)-mediated transcription both in human cells and zebrafish embryos.
alteration of the malignant behavior of cancer cells by AES is related to RND3 (显示 RND3 ELISA试剂盒) regulation.
In the presence of NUP98 (显示 NUP98 ELISA试剂盒)-HOXA9 (显示 HOXA9 ELISA试剂盒), AES caused an increase in long-term proliferation of primary human CD34 (显示 CD34 ELISA试剂盒)+ cells with a marked increase in the numbers of primitive cells.
Elevated levels of AES mRNA (显示 RUNX1 ELISA试剂盒)and (显示 RUNX1T1 ELISA试剂盒)protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens.
LRP6 (显示 LRP6 ELISA试剂盒)-ICD (显示 GNPTAB ELISA试剂盒) interacts with AES exclusively in the nucleus and represses AES mediated TCF (显示 HNF4A ELISA试剂盒)/LEF-1 (显示 LEF1 ELISA试剂盒) reporter transcription.
in a transplantation mouse model of liver metastases, expression of Yy2 (显示 YY2 ELISA试剂盒) (and therefore of Aes) is downregulated
The finding that Foxh1 (显示 FOXH1 ELISA试剂盒)-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions.
Self-renewal induced by AML1 (显示 RUNX1 ELISA试剂盒)/ETO (显示 RUNX1T1 ELISA试剂盒) in primary murine progenitors was inhibited when Aes was decreased or absent.
The Aes gene functions as an endogenous metastasis suppressor. Aes inhibits Notch (显示 NOTCH1 ELISA试剂盒) signaling by converting active Rbpj (显示 RBPJ ELISA试剂盒) transcription complexes into repression complexes on insoluble nuclear matrix.
Data suggest that Grg5 modulates the activities of transcription factors in vivo to affect Ihh (显示 IHH ELISA试剂盒) expression and the function of long bone growth plates.
Tcf4 (显示 TCF4 ELISA试剂盒) and Aes influence pituitary growth and development, and place Tcf4 (显示 TCF4 ELISA试剂盒) and Tle3 in the genetic hierarchy with Prop1 (显示 PROP1 ELISA试剂盒)
Grg5 acts as a positive regulator of Runx2 (显示 RUNX2 ELISA试剂盒) activity and is necessary for full expression and signalling of Indian hedgehog (Ihh (显示 IHH ELISA试剂盒)).
Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity.
direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothalamic neurons
GRG5/AES interacts with TCF4 (显示 TCF7L2 ELISA试剂盒) and represses Wnt (显示 WNT2 ELISA试剂盒)-mediated transcription both in human cells and zebrafish embryos.
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.
gp130-associated protein GAM
, related to Drosophila groucho
, amino enhancer of split
, amino enhancer split
, amino-terminal enhancer of split
, transducin-like enhancer of split 4 homolog of Drosophila E(spl)