anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) 抗体产品概述

Full name:
anti-ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 抗体 (ABCG2)
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ABC15, ABCG2, ABCG3, ABCP, AI428558, BCRP, Bcrp1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
列出全部抗体 基因 基因ID UniProt
 ABCG2 ABCG2 9429 Q9UNQ0
小鼠 ABCG2 ABCG2 26357 Q7TMS5
大鼠 ABCG2 ABCG2 312382 Q80W57


更多抗ATP-Binding Cassette, Sub-Family G (WHITE), Member 2的相互作用对抗体

Human ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. study concludes that miR (显示 MLXIP 抗体)-132 regulated SIRT1 (显示 SIRT1 抗体)/CREB (显示 CREB1 抗体)/ABCG2 signaling pathway contributing to the cisplatin resistance and might serve as a novel therapeutic target against gastric cancer

  2. structure of human ABCG2 determined by cryo-electron microscopy, providing the first high-resolution insight into a human multidrug transporter

  3. ABCG2 rs2231142 predicts poor response to allopurinol in gout patients.

  4. BCRP and MRP2 (显示 ABCC2 抗体) can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.

  5. Patients with active rheumatoid arthritis have an increased function of ABCB1 (显示 ABCB1 抗体) and ABCG2, and disease activity is the main determinant of this phenomena.

  6. The results indicate that human BCRP and not human P-gp (显示 ABCB4 抗体) is involved in benzylpenicillin transport.

  7. ABCG2 was further demonstrated to contribute cisplatin resistance in ALDHA1(+) colorectal cancer stem cells and can be regulated by miR (显示 MLXIP 抗体)-199a/b.

  8. altered BCRP expression and function by ammonia and H2 O2 were restored by ROS (显示 ROS1 抗体) scavenger N-acetylcysteine and ERK1/2 (显示 MAPK1/3 抗体) inhibitor U0126

  9. The results showed high ABCB1 (显示 ABCB1 抗体) and ABCG2 gene levels, which were 4.5 and 2.3 times the levels of healthy donors, respectively.

  10. With our approach for single-cell analysis, we observed SP and NSP (显示 RTN1 抗体) cells at both ends of a transporter activity continuum, demonstrating that features of transporter activity as well as DNA content are determinants of SP/NSP (显示 RTN1 抗体) identity.

Pig (Porcine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Inherently high expression of ABCG2 in endocardial endothelial cells protects them against apoptosis in presence of anticancer agents.

Cow (Bovine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. ABCG2 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.

  2. These findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality.

  3. The results suggest that a mutation of SCD1 (显示 SCD 抗体), but not LEPR (显示 LEPR 抗体) or ABCG2, might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  4. P-gp (显示 ABCB4 抗体), Bcrp and Mrp1 (显示 ABCC1 抗体) are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport.

  5. This study has, for the first time, confirmed the expression of ABCG2 in epithelial cells of the bovine rumen.

  6. These results contribute to the role of ABCG2 in cytoprotection and disposition in important tissue barriers and may have important implications for veterinary pharmacotherapy of dairy animals.

  7. Generated cell culture model allows rapid and high-throughput screening of potential ruminant ABCG2 substrate, increasing the understanding of carrier-associated secretion of xenobiotics into milk.

  8. Bovine ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the veterinary antibiotic danofloxacin.

  9. ABCG2 plays a role in mammary epithelial cell proliferation, and functional polymorphisms in this gene may influence the cellular compartment of the mammary gland and potentially milk production.

  10. The effect of the Y581S polymorphism of ABCG2 on transcellular transport of veterinary drugs was studied because this could alter substrate pharmacokinetics and milk residues.

Mouse (Murine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Bcrp1 (Abcg2), the murine orthologue of the ABC transporter Breast Cancer Resistance Protein (BCRP, ABCG2), has at least four alternative promoters that are designated by the corresponding four alternative first exons produced: E1U, E1A (显示 BCKDHA 抗体), E1B (显示 BCKDHB 抗体), and E1C. In-silico protocols are presented to predict alternative promoter usage for Bcrp1 (显示 BANF1 抗体).

  2. Report novel pyrimido[1'',2'':1,5]pyrazolo[3,4-b]quinolones that reverse ABCG2-mediated resistance in cancer cells.

  3. Immunostaining and highly-sensitive in situ hybridization was used to assess the distribution of UA transporters: GLUT9/URATv1 (显示 SLC2A9 抗体), ABCG2, and URAT1 (显示 SLC22A12 抗体). Immunostaining for GLUT9 (显示 SLC2A9 抗体) was observed in ependymal cells, neurons, and brain capillaries. Immunostaining for ABCG2 was observed in the choroid plexus epithelium and brain capillaries, but not in ependymal cells. These results were validated by in situ hybridization.

  4. [(18)F]Mefway is modulated by P-gp (显示 ABCB4 抗体), and not by Bcrp in rodents.

  5. P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier

  6. Coadministration of ceritinib with a dual ABCB1 (显示 ABCB1 抗体) and ABCG2 inhibitor may improve treatment of brain (micro) metastases.

  7. Pparalpha (显示 PPARA 抗体) complex translocates from the cytoplasm into the nucleus and further recruits coactivators and transcription machinery which induce the transcription of Abcg2 gene and ultimately results in upregulation of Bcrp protein expression and function

  8. Among the ABC (显示 ABCB6 抗体) drug transporters, only ABCG2 was expressed at highly increased levels in a mouse G3 medulloblastoma model.

  9. The studies using Bcrp KO mice serve as an estimation of the clinical plasma concentration-time curve changes in ABCG2 421C>A variants for BCRP substrate drugs with the F ratio correcting the systemic clearance change by Bcrp knockout in Bcrp KO mice.

  10. the renal urate excretion was increased in Abcg2-knockout mice

Rabbit ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) interaction partners

  1. Functional expression of the ABCG2 efflux transporter in rabbit placenta.

  2. ABCG2-dependent dye exclusion undergoes large expansion in explant culture and becomes associated with high colony formation efficiency.

ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2) 抗原简介

Antigen Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2)

  • ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) 抗体
  • ATP-binding cassette, sub-family G (WHITE), member 2 (abcg2) 抗体
  • ATP-binding cassette, sub-family G (WHITE), member 2 (Abcg2) 抗体
  • ATP-binding cassette, subfamily G (WHITE), member 2 (Abcg2) 抗体
  • ABC15 抗体
  • ABCG2 抗体
  • ABCG3 抗体
  • ABCP 抗体
  • AI428558 抗体
  • BCRP 抗体
  • Bcrp1 抗体
  • BMDP 抗体
  • CD338 抗体
  • CDw338 抗体
  • EST157481 抗体
  • GOUT1 抗体
  • MRX 抗体
  • MXR 抗体
  • MXR1 抗体
  • UAQTL1 抗体

Protein level used designations for ABCG2

ATP-binding cassette, sub-family G, member 2 , breast cancer resistance protein , ATP-binding cassette sub-family G member 2 , ATP-binding cassette transporter subfamily G member 2 , ATP-binding cassette, sub-family G (WHITE), member 2 , ATP-binding cassette sub-family G member 2-like , ABC transporter , ATP-binding cassette transporter G2 , mitoxantrone resistance-associated protein , multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 , placenta specific MDR protein , placenta-specific ATP-binding cassette transporter , ATP-binding cassette protein G2 , brain multidrug resistance protein , ATP binding cassette superfamily G number 2 transporter , breast cancer resistance protein 1 homolog , mitoxantrone resistance protein 1 , ATP-binding cassette transporter sub-family G member 2

471251 Pan troglodytes
734088 Xenopus (Silurana) tropicalis
780508 Ovis aries
100034164 Equus caballus
100431737 Pongo abelii
9429 Homo sapiens
100036892 Xenopus laevis
423767 Gallus gallus
478472 Canis lupus familiaris
397073 Sus scrofa
536203 Bos taurus
26357 Mus musculus
100008640 Oryctolagus cuniculus
574307 Macaca mulatta
312382 Rattus norvegicus