anti-TICAM2 (TICAM2) 抗体产品概述

Full name:
anti-Toll-Like Receptor Adaptor Molecule 2 抗体 (TICAM2)
在www.antibodies-online.cn可供119 Toll-Like Receptor Adaptor Molecule 2 (TICAM2) 抗体的26不同的供货商。 再加上,我们可以发TICAM2 蛋白 (14)和数多这个蛋白质的别的产品。 总共148 TICAM2产品已列进来了。
B430113A10, MyD88-4, TICAM-2, TIRAP3, Tirp, TRAM, Trif
列出全部抗体 基因 基因ID UniProt
TICAM2 364867  
TICAM2 353376 Q86XR7
TICAM2 225471 Q8BJQ4



最受欢迎的抗anti-TICAM2 (TICAM2) 抗体


抗Rat (Rattus) TICAM2 抗体:

抗Human TICAM2 抗体:

抗Mouse (Murine) TICAM2 抗体:

所有可销售的anti-TICAM2 抗体


引用最多的anti-TICAM2 抗体

  1. Human Monoclonal TICAM2 Primary Antibody for FACS - ABIN2665412 : Enokizono, Kumeta, Funami, Horiuchi, Sarmiento, Yamashita, Standley, Matsumoto, Seya, Inagaki: Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)
    Show all 6 references for 2665412

  2. Human Polyclonal TICAM2 Primary Antibody for DB, EIA - ABIN493396 : Oshiumi, Sasai, Shida, Fujita, Matsumoto, Seya: TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 references for 493396

  3. Human Polyclonal TICAM2 Primary Antibody for DB, EIA - ABIN493528 : Oshiumi, Matsumoto, Funami, Akazawa, Seya: TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. in Nature immunology 2003 (PubMed)
    Show all 3 references for 493528

  4. Human Polyclonal TICAM2 Primary Antibody for IHC (fro), WB - ABIN265137 : ONeill, Fitzgerald, Bowie: The Toll-IL-1 receptor adaptor family grows to five members. in Trends in immunology 2003 (PubMed)
    Show all 2 references for 265137

  5. Human Polyclonal TICAM2 Primary Antibody for WB - ABIN657981 : Lysakova-Devine, Keogh, Harrington, Nagpal, Halle, Golenbock, Monie, Bowie: Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)


Human Toll-Like Receptor Adaptor Molecule 2 (TICAM2) interaction partners

  1. Data show that Toll (显示 TLR4 抗体)/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling.

  2. Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (显示 IL1B 抗体) (P = 4.3 x 10(-5)) associated with TB.

  3. TRAM (显示 TRAM1 抗体) plays a role in TLR7 (显示 TLR7 抗体) signaling through a novel signaling axis towards the activation of anti-viral immunity.

  4. TRAM (显示 TRAM1 抗体) acts as a sorting adaptor not only for TLR4 (显示 TLR4 抗体), but also for TLR2 (显示 TLR2 抗体), to facilitate signaling to IRF7 (显示 IRF7 抗体) at the endosome, which explains how TLR2 (显示 TLR2 抗体) is capable of causing type I IFN induction.

  5. A putative TRAF6 (显示 TRAF6 抗体)-binding motif in TRAM (显示 TRAM1 抗体) may mediate a new TRAM (显示 TRAM1 抗体) function in TLR4 (显示 TLR4 抗体) signaling in regulating inflammatory responses, distinct from its bridging TLR4 (显示 TLR4 抗体) and TRIF (显示 TRIM69 抗体). A TRAM (显示 TRAM1 抗体) E183A mutation abolished this.

  6. results suggest TLR adaptor molecules knockdown, such as MyD88 (显示 MYD88 抗体) or TRAM (显示 TRAM1 抗体), can decrease IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体) mRNA and increase CXCL12 (显示 CXCL12 抗体) mRNA expression in HGF (显示 HGF 抗体) and HPDLF.

  7. The homotypic interaction between TICAM-2 TIR is indispensable to present a scaffold for recruiting the monomeric moiety of the TICAM-1 (显示 TICAM1 抗体) TIR dimer.

  8. induction of both IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体) is associated with elevated TIRAP (显示 TIRAP 抗体) and reduced TRAM (显示 TRAM1 抗体) mRNA expression

  9. Data indicate that MyD88 (显示 MYD88 PLURAL_@16870@) works together with the IL-1 (显示 IL1A PLURAL_@16870@)/IL-18 (显示 IL18 PLURAL_@16870@) receptors, can interact with two distinct sorting adaptors, TRAM (显示 TRAM1 PLURAL_@16870@) and Mal (显示 MAL PLURAL_@16870@), in a conserved manner.

  10. viral inhibitor peptide of TLR4 (显示 TLR4 抗体) possibly represents a surface domain of A46 that specifically inhibits TLR4 (显示 TLR4 抗体) by masking critical binding sites on MyD88 adaptor (显示 MYD88 抗体)-like and TRIF-related adaptor molecule

Mouse (Murine) Toll-Like Receptor Adaptor Molecule 2 (TICAM2) interaction partners

  1. Stimulation of the TLR4 (显示 TLR4 抗体)-TRIF (显示 RNF138 抗体) pathway can protect against the development of allergic airway disease and that a TRIF (显示 RNF138 抗体)-dependent adjuvant effect on CD4 (显示 CD4 抗体)(+) ICOS (显示 ICOS 抗体)(+) T-cell responses may be a contributing mechanism.

  2. Monophosphoryl lipid A stimulation of a TLR4 (显示 TLR4 抗体)-TRIF (显示 RNF138 抗体)-PI3K-Akt (显示 AKT1 抗体) pathway prevents lipopolysaccharide-induced ERK (显示 EPHB2 抗体) activation in the medullar thick ascending limb.

  3. study reporst a key role for TNF (显示 TNF 抗体)/TNFR1 (显示 TNFRSF1A 抗体) in Yersinia-induced cell death of murine macrophages, which occurs despite the blockade of NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) signaling imposed by Yersinia on infected cells

  4. STING and TRIF (显示 RNF138 抗体) Contribute to Mouse Sepsis, Depending on Severity of the Disease Model

  5. the role of Toll (显示 TLR4 抗体)-like receptor (TLR) 2 (显示 TLR2 抗体), TLR4 (显示 TLR4 抗体), myeloid differentiation response gene 88, and Toll (显示 TLR4 抗体)-IL-1 (显示 IL1A 抗体) receptor domain-containing adaptor-inducing interferon-gamma (显示 IFNG 抗体) (TRIF (显示 RNF138 抗体)), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis.

  6. Juniperus rigida Sieb. extract inhibits macrophage inflammatory responses by attenuating TRIF (显示 RNF138 抗体)-dependent signaling and inflammasome activation.

  7. TRIF (显示 RNF138 抗体)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (显示 TLR4 抗体) and 3. JNK (显示 MAPK8 抗体)-dependent mechanisms likely mediate this downregulation.

  8. Data show that annexin A2 (AnxA2 (显示 ANXA2 抗体)) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4 (显示 TLR4 抗体))-initiated TRAM protein (显示 TRAM2 抗体)-TRIF (显示 RNF138 抗体) protein pathway occurring on endosomes.

  9. TRIF (显示 RNF138 抗体) mediates antibacterial defense during Gram-negative pneumonia, at least in part, by inducing IFN-x03B3; at the primary site of infection.

  10. The authors confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3 (显示 TLR3 抗体)-mediated TRIF (显示 RNF138 抗体) signaling by using TLR3 (显示 TLR3 抗体)-deficient mice.

TICAM2 抗原简介

Antigen Summary

TIRP is a Toll/interleukin-1 receptor (IL1R\; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4\; MIM 603030).

Alternative names and synonyms associated with TICAM2

  • toll-like receptor adaptor molecule 2 (Ticam2) 抗体
  • toll-like receptor adaptor molecule 2 (TICAM2) 抗体
  • B430113A10 抗体
  • MyD88-4 抗体
  • TICAM-2 抗体
  • TIRAP3 抗体
  • Tirp 抗体
  • TRAM 抗体
  • Trif 抗体

Protein level used designations for TICAM2

TIR domain-containing adapter molecule 2 , TMED7-TICAM2 readthrough , NF-kappa-B-activating protein 502 , TRIF-related adaptor molecule , cytoplasmic adaptor , putative NF-kappa-B-activating protein 502 , toll-like receptor adaptor protein 3 , toll/interleukin-1 receptor (TIR) domain-containing adapter protein , TIR domain-containing adapter protein , TRIF-related adapter molecule TRAM , Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2 , toll/interleukin-1 receptor domain-containing protein , TRIF-related adapter molecule

364867 Rattus norvegicus
100029323 Monodelphis domestica
100409449 Callithrix jacchus
100500706 Pan troglodytes
100520421 Sus scrofa
100529854 Equus caballus
100533188 Canis lupus familiaris
353376 Homo sapiens
225471 Mus musculus
539350 Bos taurus
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