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Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes.
Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4 (显示 SLC2A4 蛋白).
Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
Syntaxin-8 regulates the endocytosis of TASK-1 (显示 KCNK3 蛋白).
These results suggest that STX8 mediates the recycling of CLDN16 (显示 CLDN16 蛋白) and constitutes an important component of the CLDN16 (显示 CLDN16 蛋白) trafficking machinery in the kidney.
syntaxin 8 contributes to the regulation of CFTR (显示 CFTR 蛋白) trafficking and chloride channel (显示 CLCA1 蛋白) activity by the SNARE (显示 NAPA 蛋白) machinery
Results report that syntaxin 7 (显示 STX7 蛋白), syntaxin 8, vti1b (显示 VTI1B 蛋白) and VAMP8 (显示 VAMP8 蛋白) physically and functionally interact with CFTR (显示 CFTR 蛋白).
Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes.
Syntaxin 8 and HECTd3 (显示 HECTD3 蛋白) have similar subcellular localization.
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
, syntaxin 8
, t-SNARE family protein
, CIP-1-associated regulator of cyclin B
, syntaxin-like protein 3I35