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Human Polyclonal SMAD1 Primary Antibody for WB - ABIN1881815
Ye, Yu, Hu, Lu, Xie: Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma. in Journal of experimental & clinical cancer research : CR 2010
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Human Polyclonal SMAD1 Primary Antibody for WB - ABIN3042628
Tao, Hu, Li, Liu, Wu, Li, Fu, Wei, Luo: Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor ?/Smad pathways. in Transplantation proceedings 2011
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Human Monoclonal SMAD1 Primary Antibody for IF, IHC (p) - ABIN517610
Nakajima, Yanagihara, Nishii: Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia. in Journal of the neurological sciences 2014
Human Polyclonal SMAD1 Primary Antibody for WB - ABIN967044
Zhu, Kavsak, Abdollah, Wrana, Thomsen: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. in Nature 1999
Human Polyclonal SMAD1 Primary Antibody for WB - ABIN362414
Yamaguchi, Zhu, Yu, Sasaki, Umetsu, Kidachi, Ryoyama et al.: Serum-free mouse embryo cells generate a self-sustaining feedback loop for an astrocyte marker protein and respond to cytokines and bisphenol A in accordance with the subtle difference in their ... in Cell biology international 2007
Data show that interplay of Smad1/5 and MAP kinase (显示 MAPK1 抗体) signaling system (ERK (显示 MAPK1 抗体) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 and smad9 (显示 SMAD9 抗体) act redundantly to each other downstream of smad5 (显示 SMAD5 抗体) to mediate ventral specification and to regulate embryonic myelopoiesis.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5 (显示 SMAD5 抗体).
This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus.
LTR sequence of the MDG4 (显示 MOD(MDG4) 抗体) retrotransposon contains the MAD protein (显示 MXD1 抗体) binding site that affects the east-dependent repression
we identify key roles for the Zelda and Zerknullt transcription factors in establishing the resulting expression domain, and find widespread binding of insulator proteins to the Mad and Brinker-bound genomic regions. Analysis of embryos lacking the BEAF-32 insulator protein shows reduced transcription of a peak BMP target gene and a reduction in the number of amnioserosa cells, the fate specified by peak BMP signaling.
Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues.
During development, synaptic pMad accumulation followed the arrival and clustering of ionotropic glutamate (显示 GRIN2A 抗体) receptors at neuromuscular junction synapses.
The actions of Brat at synapses are mediated through mothers against decapentaplegic (Mad), the signal transduction effector of the bone morphogenetic protein (BMP) signaling pathway.
Mad has distinct signal transduction roles in the BMP (显示 TGFb 抗体) and Wnt (显示 WNT4 抗体) pathways depending on its phosphorylation state.
Yorkie (显示 YAP1 抗体) and Mad physically bind each other, and 410 bp minimal enhancer of bantam that responds to Yorkie:Mad in vivo and in cultured cells, was identified.
Heterodimers of SAX and TKV play an important role in extending the BMP activity gradient by facilitating DPP diffusion and assisting GBB signaling through functional complexes with type II receptors.
importin-beta11 function interacts with the bone morphogenic protein (显示 TGFb 抗体) pathway to regulate a pool of phosphorylated mothers against decapentaplegic that must be present at the presynapse for its proper development and function
Data show that miR (显示 MLXIP 抗体)-26b-5p suppresses Twist1 (显示 TWIST1 抗体)-induced EMT (显示 ITK 抗体), invasion, and metastasis of HCC (显示 FAM126A 抗体) cells by targeting SMAD1 (显示 GARS 抗体).
Testosterone promoted tube formation of human umbilical endothelial cells, which was blocked by c-Src (显示 SRC 抗体) and ERK1/2 (显示 MAPK1/3 抗体) inhibitors or by the knockdown of Smad1 (显示 GARS 抗体).
Low doses of IL1B (显示 IL1B 抗体) activate the BMP/Smad signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (显示 IL1B 抗体) inhibit BMP/Smad signaling through the activation of NF-kappaB (显示 NFKB1 抗体) and MAPK (显示 MAPK1 抗体) signaling, inhibiting osteogenesis.
Store operated calcium entry negatively regulates the Smad1 (显示 GARS 抗体) signaling pathway and inhibits Col (显示 HDAC1 抗体) IV protein production in glomerular mesangial cells.
A significant association was found between the low expression of inhibitory protein SMAD-7 (显示 SMAD7 抗体) and both zeta-chain-associated protein kinase (显示 CDK7 抗体) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2 (显示 SMAD2 抗体)/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (显示 GARS 抗体)/8 and lower SMAD-4 (显示 SMAD4 抗体) expression in chronic lymphocytic leukemia cells
melatonin treatment was found to downregulate TNFalpha (显示 TNF 抗体)-induced SMURF1 (显示 SMURF1 抗体) expression and then decrease SMURF1 (显示 SMURF1 抗体)-mediated ubiquitination and degradation of SMAD1 (显示 GARS 抗体) protein
The expression of specific targets Smad1 (显示 GARS 抗体) and Osterix (显示 SP7 抗体) was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (显示 MUC7 抗体)+). As miR (显示 MLXIP 抗体)-30b, miR (显示 MLXIP 抗体)-133a, and miR (显示 MLXIP 抗体)-143 are negatively regulated by Pi and restored by Mg(2 (显示 MUC7 抗体)+) with a congruent modulation of their known targets Runx2 (显示 RUNX2 抗体), Smad1 (显示 GARS 抗体), and Osterix (显示 SP7 抗体), our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
the BMP-2 (显示 BMP2 抗体)/Smad1 (显示 GARS 抗体)/5/RUNX2 (显示 RUNX2 抗体) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (显示 BGLAP 抗体) synth
Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1 (显示 GARS 抗体).
The expression SMAD1 (显示 GARS 抗体) protein showed a significant correlation with lung cancer differentiation and lymphatic metastasis (P < 0.05), but not with genders, ages, tumor sizes and histological types of lung cancer patients (P>0.05).
AA-enhanced cardiomyogenesis thus relies on the ability of AA to modulate the ratio of SMAD signaling among the TGFbeta (显示 TGFB1 抗体)-superfamily receptor signaling pathways
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (显示 RUNX2 抗体)) expression through S1PR2 (显示 S1PR2 抗体)/RhoA (显示 RHOA 抗体)/ROCK/Smad1/5/8 signaling.
these results identify the PI3K-GSK3 (显示 GSK3b 抗体)-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis.
We discovered that Smad1/5/4-Amhr2 (显示 AMHR2 抗体)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2 (显示 AMHR2 抗体)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (显示 TGFB1 抗体)-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.
these results identify a novel function of YAP (显示 YAP1 抗体) in neocortical astrocytic differentiation and proliferation, and reveal a BMP2 (显示 BMP2 抗体)-YAP (显示 YAP1 抗体)-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex.
Dynamin (显示 DNM1 抗体)-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2 (显示 BMP2 抗体)) and its receptors is dispensable for the initiation of Smad signaling
Thyroid-specific Smad1 and Smad5 (显示 SMAD5 抗体) double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 and Smad5 (显示 SMAD5 抗体) have overlapping functions to govern hepcidin (显示 HAMP 抗体) transcription. Moreover, erythropoietin (显示 EPO 抗体) and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin (显示 HAMP 抗体) expression.
Actin cytoskeleton depolymerization inhibites BMP2 (显示 BMP2 抗体) signaling via blocking of Smad by dephosphorylated CNN1 (显示 CNN1 抗体) in osteoblast cells under simulated microgravity.
interactions between miR (显示 MYLIP 抗体)-26 and the Smad1 3'UTR (显示 UTS2R 抗体) modulate Smad1 function in the establishment of axial patterning.
a detailed computational model for TGF-beta (显示 TGFB1 抗体) signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2 (显示 SMAD2 抗体)/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 抗体).
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
MAD homolog 1
, SMAD, mothers against DPP homolog 1
, mothers against decapentaplegic homolog 1
, mothers against decapentaplegic-like protein 1
, MAD (mothers against decapentaplegic, Drosophila) homolog 1
, SMA- and MAD-related protein 1
, SMAD 1
, SMAD family member 1
, mothers against DPP homolog 1
, mother against decapentaplegic
, mothers against decapentaplegi
, mothers against decapentaplegic
, mothers against dpp
, phosphorylated smad
, MAD, mothers against decapentaplegic homolog 1
, Mad-related protein 1
, TGF-beta signaling protein 1
, transforming growth factor-beta signaling protein 1
, transforming growth factor-beta-signaling protein 1
, Smad 1
, mad-related protein 1
, mothers-against-DPP-related 1
, MAD homolog1 (mothers against decapentaplegic, Drosophila)
, mothers against DPP
, BMP pathway effector
, BMP signal transducer Smad1
, Sma- and Mad-related protein 1