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Data suggest that kinase domains of neurotrophin (显示 BDNF ELISA试剂盒) receptor isoforms, TRKA (显示 NTRK1 ELISA试剂盒), TRKB (显示 NTRK2 ELISA试剂盒), and TRKC, exhibit a bulky phenylalanine gatekeeper, leading to a small and unattractive back pocket/binding site for antineoplastic kinase inhibitors. [REVIEW]
Pan-Trk (显示 NTRK1 ELISA试剂盒) immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
5 gastrointestinal stromal tumors cases lacking alterations in the KIT/PDGFRA (显示 PDGFRA ELISA试剂盒)/SDHx/RAS pathways, including two additional cases with FGFR1 (显示 FGFR1 ELISA试剂盒)-TACC1 (显示 TACC1 ELISA试剂盒) and ETV6 (显示 ETV6 ELISA试剂盒)-NTRK3 fusions, are reported.
High expression of TrkC is associated with glioblastoma.
Study found that copy number variations of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer.
we demonstrate the expression of the ETV6-NTRK3 fusion oncogene (显示 RAB1A ELISA试剂盒) in a small subset of inflammatory myofibroblastic tumors
ETV6 (显示 ETV6 ELISA试剂盒)-NTRK3 translocated papillary thyroid carcinomas are locoregionally aggressive and can metastasize distantly.
We report 6 cases of secretory carcinomas of the skin harboring the ETV6 (显示 ETV6 ELISA试剂盒)-NTRK3 gene fusion
ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions are identified in Spitz tumours and demonstrated that NTRK3 fusions constitutively activate the mitogen-activated protein kinase, phosphoinositide 3-kinase and phospholipase Cgamma1 pathways in melanocytes.
A subset of ALK (显示 ALK ELISA试剂盒)-negative inflammatory myofibroblastic tumour (IMT) have rearrangement of ROS1 (显示 ROS1 ELISA试剂盒), ETV6 (显示 ETV6 ELISA试剂盒) or NTRK3 as a possible oncogenic mechanism.
our data suggest that Runx3 (显示 RUNX3 ELISA试剂盒) may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk (显示 NTRK1 ELISA试剂盒) mouse mutant with a pain phenotype
TrkC expression in E13.5 VCG neurons requires NeuroD (显示 NEUROD1 ELISA试剂盒) and that TrkC expression may be necessary for the normal migration and innervations of those neurons.
The dependence receptor TrkC interacts with Cobra1 (显示 COBRA1 ELISA试剂盒).TrkC killer fragment shuttles with Cobra1 (显示 COBRA1 ELISA试剂盒) to the mitochondria to engage apoptosis.
ETV6 (显示 ETV6 ELISA试剂盒)-SAM (显示 TTN ELISA试剂盒) domain interface mutations block ETV6 (显示 ETV6 ELISA试剂盒)-NTRK3-induced cellular transformation
This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories.
Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice.
find that both IRS1 (显示 IRS1 ELISA试剂盒) and kinase active IGF1R (显示 IGF1R ELISA试剂盒) are required for ETV6 (显示 ETV6 ELISA试剂盒)-NTRK3 transformation, that tyrosine phosphorylated IRS1 (显示 IRS1 ELISA试剂盒) is present in high molecular weight complexes with EN and IGF1R (显示 IGF1R ELISA试剂盒), and that EN colocalizes with IGF1R (显示 IGF1R ELISA试剂盒) at the plasma membrane
Data describe the distribution and changes of TrkB (显示 NTRK2 ELISA试剂盒) and TrkC in the dopamine neurons of the substantia nigra by comparison of control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP (显示 PTPN2 ELISA试剂盒)) Parkinson disease mouse model.
Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma (显示 PTPRS ELISA试剂盒) generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways.
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein
, ETV6-NTRK3 fusion
, NT-3 growth factor receptor
, tyrosine kinase receptor C
, neural receptor protein-tyrosine kinase (trkC)
, trkC tyrosine kinase
, neurotrophic tyrosine kinase receptor type 3
, tyrosine kinase C receptor, TrkC receptor, high-affinity neurotrophin receptor
, neurotrophic tyrosine kinase, receptor, type 3
, NT-3 growth factor receptor-like