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Human AXL ELISA Kit for Sandwich ELISA - ABIN624944
Hsiao, Lin, Hsieh, Chu, Shieh, Hsieh, Lee, Hung: Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. in The Journal of clinical endocrinology and metabolism 2013
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Data indicate a role for AXL receptor tyrosine kinase (AXL) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (显示 EGFR ELISA试剂盒)) and suggest that AXL-mediated SRC (显示 SRC ELISA试剂盒) family kinases (SFKs) and neuregulin-1 (NRG1 (显示 NRG1 ELISA试剂盒)) expression promote this process.
Combination of high serum levels of soluble AXL and BNP had greater predictive value for heart failure than BNP alone.
These results demonstrate that Gas6 (显示 GAS6 ELISA试剂盒)/Axl axis confers aggressiveness in breast cancer.
a lower stability and greater dynamic nature of the Axl kinase domain
Silencing AXL or the inhibition of AXL kinase activity significantly inhibits tumor cell migration and invasion in colorectal cancer.
we identify PROS1 (显示 PROS1 ELISA试剂盒) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL expression
Studies indicate that aberrant AXL receptor tyrosine kinase (AXL) signaling and development of an epithelial-to-mesenchymal transition (EMT (显示 ITK ELISA试剂盒)) phenotype underlie resistance of anaplastic lymphoma kinase (ALK (显示 ALK ELISA试剂盒) F1174L)-driven neuroblastoma (显示 ARHGEF16 ELISA试剂盒) (NB) cells to TAE684 and its derivatives.
Studied axl kinase as a negative regulator of an alveolar epithelial cell phenotype; results found that inhibition of Axl kinase could form epithelial adhesion structure and augment surfactant protein production via the MET of human lung multi-potent cells.
AXL is efficiently and sequentially cleaved by alpha- and gamma-secretases in various types of cancer cell lines. The AXL intracellular domain cleavage product translocates into the nucleus via a nuclear localization sequence that harbored a basic HRRKK motif.
a relationship between AXL and the cellular response to DNA damage whereby abrogation of AXL signaling leads to accumulation of the DNA-damage markers gammaH2AX (显示 H2AFX ELISA试剂盒), 53BP1 (显示 TP53BP1 ELISA试剂盒), and RAD51 (显示 RAD51 ELISA试剂盒).
These results demonstrate that AXL is essential for limiting the immunosuppressive effects of type I interferons and enabling the induction of protective antiviral adaptive immunity.
GAS6 (显示 GAS6 ELISA试剂盒)-AXL signaling-mediated autophagy induction in murine macrophages ameliorates hepatic inflammatory responses by inhibiting NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome activation.
Both Axl+/- and Axl-/- suckling mice supported the replication of Zika virus.
reciprocal activation of Axl and Mer (显示 ERH ELISA试剂盒) receptor tyrosine kinases has a major impact on the outcome of renal inflammation.
Axl is critical for survival of T lymphocytes, especially during vascular remodeling in hypertension.
Axl, Mertk (显示 MERTK ELISA试剂盒) and Tyro3 (显示 TYRO3 ELISA试剂盒) receptors are not required for Zika virus entry and infection.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (显示 ADAM10 ELISA试剂盒) and TACE (ADAM17 (显示 ADAM17 ELISA试剂盒)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (显示 GAS6 ELISA试剂盒)/Axl and Akt (显示 AKT1 ELISA试剂盒)/FoxO1a (显示 FOXO1 ELISA试剂盒) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
activation of receptor tyrosine kinase (显示 RET ELISA试剂盒) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog