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Mouse (Murine) AXL Primary Antibody for ELISA - ABIN1889307
OBryan, Frye, Cogswell, Neubauer, Kitch, Prokop, Espinosa, Le Beau, Earp, Liu: axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. in Molecular and cellular biology 1991
Study provides evidence that AXL and MET are associated with cell proliferation and metastasis in lung cancer, and the crosstalk between these receptors affects tumor progression.
these results confirm the correlation between AXL and PKCalpha (显示 PKCa ELISA试剂盒), and suggest PKCalpha (显示 PKCa ELISA试剂盒)-AXL signaling may be a treatment target, particularly in malignant cancer cells.
Authors concluded that the molecular mechanisms of AXL mediated resistance involved in the increased activity of the PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) and MAPK (显示 MAPK1 ELISA试剂盒)/ERK1/2 (显示 MAPK1/3 ELISA试剂盒) pathways, and AXL overexpression could promote resistance, but it can be weakened when AXL expression is silenced.
The study suggests that Axl may play a role in the function of endothelial progenitor cells, thereby being involved in the pathogenesis of preeclampsia.
Data show that strong AXL expression in surgically resected that lung adenocarcinomas (LADs) was a predictor of poor prognosis.
In this paper, we review the biology of the Gas6 (显示 GAS6 ELISA试剂盒)/Tyro3 (显示 TYRO3 ELISA试剂盒), Axl, and MerTK (显示 MERTK ELISA试剂盒)(collectively named TAM (显示 CCNA1 ELISA试剂盒) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
Data show that mononuclear leu (显示 ADAM10 ELISA试剂盒)kocytes (PBMC) AX (显示 ADAM17 ELISA试剂盒)L receptor tyrosine kinase (Axl) is rescued by combined matrix metalloproteases ADAM10 and TACE (ADAM17) inhibition.
suggest that targeting receptor tyrosine kinase (显示 RET ELISA试剂盒) AXL (RTK-AXL) with BMS-777607 could represent a regimen for the treatment of primary and recurrent glioblastoma multiforme (GBM).
AXL is frequently expressed in high-grade serous ovarian cancers and its expression is significantly associated to tumors displaying poor prognosis.
Data suggest that AXL receptor tyrosine kinase (Axl) may facilitate tumour progression by promoting nasopharyngeal carcinoma (NPC (显示 NPC1 ELISA试剂盒)) cell migration and invasion.
Axl plays an essential role in the regulation of NK cell development as well as natural killer effector function.
Matrix metalloproteases ADAM10 (显示 ADAM10 ELISA试剂盒) and TACE (ADAM17 (显示 ADAM17 ELISA试剂盒)) cleave AXL receptor tyrosine kinase (Axl) in lupus-prone leukocytes.
Gas6 (显示 GAS6 ELISA试剂盒)/Axl and Akt (显示 AKT1 ELISA试剂盒)/FoxO1a (显示 FOXO1 ELISA试剂盒) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Axl allows specific identification of airway macrophages, and that its expression is critical for macrophage functional compartmentalization in the airspaces or lung interstitium.
results establish TAM (显示 CCNA1 ELISA试剂盒) receptors as both controllers of microglial physiology and potential targets for therapeutic intervention in central nervous system disease
These results suggest that TAM (显示 CCNA1 ELISA试剂盒) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Gas6 (显示 GAS6 ELISA试剂盒)-induced Axl signaling is a critical driver of pancreatic cancer progression.
The results indicate that Axl and Mer (显示 ERH ELISA试剂盒) receptors cooperatively regulate the systemic immune tolerance to male germ cell antigens.
Vascular depletion of Axl reduced vein graft stiffness. Axl expression determined the STAT1 (显示 STAT1 ELISA试剂盒)-SOCS1 (显示 SOCS1 ELISA试剂盒) balance in vein graft intima and progression of the remodeling.
Gas6 (显示 GAS6 ELISA试剂盒)/Axl signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (显示 AKT1 ELISA试剂盒)/FoxO (显示 FOXO3 ELISA试剂盒) signaling pathway.
activation of receptor tyrosine kinase (显示 RET ELISA试剂盒) Axl inhibits the osteogenic differentiation of vascular pericytes.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.
, AXL transforming sequence/gene
, tyrosine-protein kinase receptor UFO
, adhesion-related kinase
, ufo oncogene homolog