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DLP (显示 DMD ELISA试剂盒) and ASF1 are part of a predeposition complex, which is recruited by XNP (显示 ATRX ELISA试剂盒) and is necessary to prevent DNA exposure in the nucleus.
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a (显示 ASF1A ELISA试剂盒) by TLK (显示 TLK2 ELISA试剂盒) kinases.
dASF1 has a direct role in modifying chromatin structure during DNA replication and this function of dASF1 is important for the processivity of the replication machinery.
Asf1 is directed via interactions with sequence-specific complexes to mediate silencing of specific target genes.
Histone chaperones ASF1 and NAP1 (显示 NAP1L1 ELISA试剂盒) differentially modulate removal of active histone marks by LID-RPD3 (显示 HDAC1 ELISA试剂盒) complexes during NOTCH (显示 NOTCH1 ELISA试剂盒) silencing.
Findings suggest MALAT1 increases AKAP-9 (显示 AKAP9 ELISA试剂盒) expression by promoting SRPK1 (显示 SRPK1 ELISA试剂盒)-catalyzed SRSF1 phosphorylation in CRC (显示 CALR ELISA试剂盒) cells. These results reveal a novel molecular mechanism by which MALAT1 regulates AKAP-9 (显示 AKAP9 ELISA试剂盒) expression in CRC (显示 CALR ELISA试剂盒) cells.
high level of SF2, as a novel oncoprotein in RCC (显示 XRCC1 ELISA试剂盒), was significantly associated with poor survival in a large cohort of RCC (显示 XRCC1 ELISA试剂盒) specimens. Taken together, our study presents a road map for the prediction and validation of miR (显示 MLXIP ELISA试剂盒)-766-3p/SF2 axis and thus imparts a therapeutic way for further RCC (显示 XRCC1 ELISA试剂盒) progression.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
We present a joint atomistic molecular dynamics (MD) and experimental study of two RRM-containing proteins bound with their single-stranded target RNAs, namely the Fox-1 (显示 A2BP1 ELISA试剂盒) and SRSF1 complexes.The simulations predict unanticipated specific participation of Arg142 at the protein-RNA interface of the SRFS1 complex, which is subsequently confirmed by NMR and ITC measurements
Using NMR spectroscopy with two separately expressed domains of SRSF1, we showed that several residues in the RNA-binding motif 2 interact with the N-terminal region of the RS domain (RS1 (显示 RS1 ELISA试剂盒)).
Especially, in SRSF1 morphants, bone cartilage formation was reduced in the brain and Nkx-2.5 (显示 NKX2-5 ELISA试剂盒) expression was dramatically reduced in the heart of SRSF1 morphants. In addition, a dramatic reduction in functional chordin (显示 CHRD ELISA试剂盒) RNA in SRSF1 morphants was observed suggesting that chordin (显示 CHRD ELISA试剂盒) is one of the targets of SRSF1. Thus, we concluded that SRSF1 is an essential factor for pattern formation including heart, cartilage and germ lay
results strongly support SRSF1 as a prognostic biomarker in SCLC and provide a rationale for personalized therapy in SCLC
NSrp70 (显示 NSRP1 ELISA试剂盒) acts as a new molecular counterpart for alternative splicing of target RNA, counteracting SRSF1 and SRSF2 (显示 SRSF2 ELISA试剂盒) splicing activity.
we have identified for the first time a potential mechanism that involves the essential splicing factor (显示 SLU7 ELISA试剂盒) ASF/SF2 through which morphine regulates splicing specificity of the MOR (显示 OPRM1 ELISA试剂盒) encoding gene, OPRM1 (显示 OPRM1 ELISA试剂盒).
Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H (显示 HNRNPH1 ELISA试剂盒)-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains.
The expression levels of three splicing factors, ESRP1 (显示 ESRP1 ELISA试剂盒), PTB (显示 PTBP1 ELISA试剂盒) and SF2/ASF, are significantly altered during cardiac hypertrophy in mice.
RRP1B suppresses metastatic progression by altering the transcriptome through its interaction with splicing regulators such as SRSF1
Deletion of RRM1 (显示 RRM1 ELISA试剂盒) eliminated the splicing activity of SRSF1 and thus cellular transformation.
Specific effects on regulated splicing by SR proteins SRSF1 and SRSF2 (显示 SRSF2 ELISA试剂盒) depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.
Treatment with IL-17 (显示 IL17A ELISA试剂盒) prolongs the half-life of chemokine (显示 CCL1 ELISA试剂盒) CXCL1 (显示 CXCL1 ELISA试剂盒) mRNA via the adaptor TRAF5 (显示 TRAF5 ELISA试剂盒) and the splicing-regulatory factor SF2 (ASF).
analysis of the miRNA-mediated interaction between leukemia/lymphoma-related factor (LRF (显示 ZBTB7A ELISA试剂盒)) and alternative splicing factor/splicing factor (显示 SLU7 ELISA试剂盒) 2 (ASF/SF2) affects cell senescence and apoptosis
Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 (显示 SMN1 ELISA试剂盒) causes spinal muscular atrophy in the absence of SMN1 (显示 SMN1 ELISA试剂盒)
Both hnRNP A1 (显示 HNRNPA1 ELISA试剂盒) and alternative splicing factor/splicing factor (显示 SLU7 ELISA试剂盒) 2 contents rose in adenomas and during injury-induced hyperplasia compared to control lungs
These results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated.
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 13.
, anti- silencing function 1
, anti-silencing factor
, splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)
, SR splicing factor 1
, alternative-splicing factor 1
, pre-mRNA-splicing factor SF2, P33 subunit
, splicing factor 2
, splicing factor, arginine/serine-rich 1
, splicing factor arginine/serine-rich 1
, splicing factor, arginine/serine-rich 1B
, pre-mRNA-splicing factor SRp30a
, splicing factor, arginine/serine-rich 1 (ASF/SF2)
, serine/arginine-rich splicing factor 1B
, splicing factor, arginine/serine-rich 1b