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Human Corin Protein expressed in HEK-293 Cells - ABIN2712504
Yin, Li, Zhang, Yang, Sun, Cao, Xiang: Sensitive and low-background electrochemical assay of corin activity via supramolecular recognition and rolling circle amplification. in Analytica chimica acta 2016
Residues Lys (显示 LYZ 蛋白)-71, Phe-72 and Gln-73 serve as a novel retention motif in the intracellular pathway to regulate corin cell surface expression and activation.
N-glycans at different sites may play distinct roles in regulating the cell membrane targeting, zymogen activation, and ectodomain shedding of corin
These results provide the first experimental evidence that corin expression plays a role in cardiomyopathy by modulating myocardial fibrosis, cardiac function, heart failure, and survival.
Data show that KO/TgV mice had significantly higher levels of proatrial natriuretic peptide in the heart compared with that in control KO/TgWT mice, indicating that the corin variant was defective in processing natriuretic peptides in vivo.
Lack of corin in mice impairs their adaptive renal response to high dietary salt, suggesting that corin deficiency may represent an important mechanism underlying salt-sensitive hypertension.
results indicate that corin and ANP (显示 NPPA 蛋白) are essential for physiological changes at the maternal-fetal interface, suggesting that defects in corin and ANP (显示 NPPA 蛋白) function may contribute to pre-eclampsia
Data indicate that Corin's involvement in ANP (显示 NPPA 蛋白) processing is a key element in the heart's response to increased hemodynamic load
Ectodomain shedding and autocleavage of the cardiac membrane protease corin.
corin might be involved in the salt retention seen in glomerular diseases.
Insufficient corin activation is expected to prevent natriuretic peptide processing and may contribute to body fluid retention and impaired cardiac function in patients with heart failure.
We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension.
Corin and atrial natriuretic peptide (显示 NPPA 蛋白) A (显示 NPPA 蛋白) were most abundant in the proximal convoluted tubules and the medullary connecting ducts.
CORIN expression is significantly downregulated in human masticatory mucosa during wound healing
serum levels of corin are significantly decreased in acute myocardial infarction patients
Data show that both furin (显示 FURIN 蛋白) and brain type natriuretic peptide (BNP) were more sensitive than corin in predicting cardiovascular complications in type 2 diabetes mellitus (T2DM) patients.
Circulating corin concentrations are related to infarct size in patients after ST-segment elevation myocardial infarction
Hypertensive participants had an increased serum corin level compared to those without hypertension, suggesting that corin may play a role in the pathology of hypertension.
Serum soluble corin was significantly and positively associated with dyslipidemia
Plasma corin levels decreased significantly from preoperative concentrations after coronary artery bypass graft surgery.
corin may play an important role in the pathology of atrial fibrillation
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
corin, serine peptidase
, novel protein similar to H.sapiens CORIN, corin, serine peptidase (CORIN)
, atrial natriuretic peptide-converting enzyme-like
, atrial natriuretic peptide-converting enzyme
, low density lipoprotein receptor-related protein 4
, low density lipoprotein-related protein 4
, pro-ANP-converting enzyme
, heart-specific serine proteinase ATC2
, transmembrane protease serine 10