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Human HDAC5 ELISA Kit for Sandwich ELISA - ABIN420524
Alam, Rashid, Kabir, Raqib, Ahmad: On birth single dose live attenuated OPV and BCG vaccination induces gut cathelicidin LL37 responses at 6 week of age: a natural experiment. in Vaccine 2014
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HDAC5 is a negative predictor of disease-free and overall survival in pancreatic neuroendocrine tumor patients.
Interference with both glucose and glutamine (显示 GFPT1 ELISA试剂盒) supply in HDAC5-inhibited cancer cells significantly increases apoptotic cell death.
these results suggest that HDAC5 is critical in regulating LSD1 (显示 KDM1A ELISA试剂盒) protein stability through post-translational modification, and the HDAC5-LSD1 (显示 KDM1A ELISA试剂盒) axis has an important role in promoting breast cancer development and progression.
The expression of HDAC5 was significantly increased in endothelial cells (ECs) from patients with systemic sclerosis (SSc (显示 CYP11A1 ELISA试剂盒)) compared to healthy control endothelial cells. Silencing of HDAC5 in SSc (显示 CYP11A1 ELISA试剂盒) ECs restored normal angiogenesis. HDAC5 knockdown followed by ATAC (显示 XCL1 ELISA试剂盒)-seq assay in SSc (显示 CYP11A1 ELISA试剂盒) ECs identified key HDAC5-regulated genes involved in angiogenesis and fibrosis, such as CYR61 (显示 CYR61 ELISA试剂盒), PVRL2 (显示 PVRL2 ELISA试剂盒), and FSTL1 (显示 FSTL1 ELISA试剂盒).
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (显示 HIPK2 ELISA试剂盒) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5-homeodomain-interacting protein kinase-2 (显示 HIPK2 ELISA试剂盒)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.
HDAC5 promotes cellular proliferation through the upregulation of cMet, and may provide a novel therapeutic target for the treatment of patients with Wilms' tumor.
HDAC5 and HDAC6 (显示 HDAC6 ELISA试剂盒) were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.
Formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT (显示 ITK ELISA试剂盒) through inhibition of HDAC5.
These results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages.
MAP3K4 (显示 MAP3K4 ELISA试剂盒) activity controls epithelial-to-mesenchymal transition through the ubiquitination and degradation of HDAC6 (显示 HDAC6 ELISA试剂盒).
HDAC6 (显示 HDAC6 ELISA试剂盒) is a critical regulator of a pro-apoptotic p53 (显示 TP53 ELISA试剂盒) K120 acetylation and mitochondrial function in mesenchymal stem cells
class IIa HDAC (显示 HDAC3 ELISA试剂盒) function could be used to enhance metabolic health in chronic diseases driven by physical inactivity.
HDAC6 (显示 HDAC6 ELISA试剂盒) inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (显示 CA2 ELISA试剂盒)+) levels.
These data thus reveal that HDAC6 (显示 HDAC6 ELISA试剂盒) represses IL-17 (显示 IL17A ELISA试剂盒) production in T cells, providing novel insights into the role of HDAC6 (显示 HDAC6 ELISA试剂盒) in the immune system.
A decrease of HDAC6 (显示 HDAC6 ELISA试剂盒) expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer.
HDAC5 emerges as a cellular conductor of MEF2C (显示 MEF2C ELISA试剂盒) and M6a (显示 GPM6A ELISA试剂盒) activity and is regulated by miR (显示 MLXIP ELISA试剂盒)-124 and miR (显示 MLXIP ELISA试剂盒)-9 to control neurite development.
HDAC6 (显示 HDAC6 ELISA试剂盒) inhibition reduces tumor growth and PD-L1 (显示 CD274 ELISA试剂盒) production in vivo.
Specific HDAC6 (显示 HDAC6 ELISA试剂盒) inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP (显示 TMPRSS5 ELISA试剂盒) levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 (显示 HDAC6 ELISA试剂盒) could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 (显示 HDAC6 ELISA试剂盒) protein).
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
Regulation of flowering time by the histone deacetylase HDA5
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (显示 PKD2 ELISA试剂盒)-histone deacetylase 5-Kruppel-like factor signaling.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase 5
, histone deacetylase mHDA2
, scurfy candidate 6