LTA 蛋白 (LTA)产品概述

Full name:
Lymphotoxin-alpha 蛋白 (LTA)
在www.antibodies-online.cn可供74 Lymphotoxin-alpha (LTA) 蛋白的22不同的供货商。 再加上,我们可以发LTA 抗体 (231)LTA 试剂盒 (97)和数多这个蛋白质的别的产品。 总共411 LTA产品已列进来了。
hlb382, LT, LT-alpha, LT-[a], LTalpha, Ltx, LT[a], TNF-beta, TNFB, TNFSF1, Tnfsf1b
列出全部蛋白 基因 基因ID UniProt
LTA 16992 P09225
LTA 4049 P01374
LTA 25008 Q06332


按照种类LTA 蛋白 (LTA)


引用最多的LTA 蛋白

  1. Chemical LTA Protein expressed in Escherichia coli (E. coli) - ABIN2002479 : Williams-Abbott, Walter, Cheung, Goh, Porter, Ware: The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for 2002479

  2. Human LTA Protein expressed in Escherichia coli (E. coli) - ABIN667775 : Messer, Spengler, Jung, Honold, Blömer, Pape, Riethmüller, Weiss et al.: Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced ... in The Journal of experimental medicine 1991 (PubMed)
    Show all 2 references for 667775

  3. Chemical LTA Protein expressed in HEK-293 Cells - ABIN2181836 : Gray, Aggarwal, Benton, Bringman, Henzel, Jarrett, Leung, Moffat, Ng, Svedersky: Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. in Nature 1985 (PubMed)
    Show all 2 references for 2181836

  4. Human LTA Protein expressed in Escherichia coli (E. coli) - ABIN1305059 : Paul, Ruddle: Lymphotoxin. in Annual review of immunology 1988 (PubMed)


Mouse (Murine) Lymphotoxin-alpha (LTA) interaction partners

  1. Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP (显示 AIP 蛋白) associated secondary extra pancreatic pathologies.

  2. These data demonstrate that lymphotoxin (显示 LTB 蛋白)-expressing cells, such as Th1 (显示 HAND1 蛋白) cells, mediate stromal keratitis.

  3. TNFalpha (显示 TNF 蛋白) and LTalpha mediate post-myocardial infarction cardiac dysfunction via TNFR1 (显示 TNFRSF1A 蛋白) stimulation, whereas TNFR2 (显示 TNFRSF1B 蛋白) activation is cardioprotective against ischemic injury.

  4. findings show that soluble lymphotoxin alpha (sLTalpha3) produced by RORgammat(+) innate lymphoid cells controls T cell-dependent IgA induction in the lamina propria via regulation of T cell homing to the gut (显示 GUSB 蛋白)

  5. Data suggest that among many cytokines increased after myocardial ischemia/reperfusion (MI/R), lymphotoxin-alpha (Lta) is the only cytokine remaining elevated 24-72 h after reperfusion; LTa appears to suppress adiponectin expression following MI/R.

  6. study reports that mice deficient in lymphotoxin (显示 LTB 蛋白), a key molecule in gut (显示 GUSB 蛋白) immunity, were resistant to diet-induced obesity

  7. Data from lymphotoxin-alpha knockout mice suggest that lymphotoxin-alpha contributes to diet-induced weight gain and adiposity (leading to obesity) and is required to modulate accumulation of immune cells in adipose tissue (as in obesity).

  8. Grafts deficient in lymphotoxin-alpha have an attenuated capacity to induce graft-versus-host disease.

  9. Our findings suggest a contribution of lymphotoxin alpha in the control of chronic M. tuberculosis infection.

  10. The organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin alpha; however, the organization and recruitment of lymphocytes within NALT are dependent on LT alpha.

Human Lymphotoxin-alpha (LTA) interaction partners

  1. Fequencies of polymorphic allele and genotypes for the lymphotoxin-alpha gene, position +252 (rs909253), in Brazilian women with preeclampsia

  2. The allelic frequencies of LTA SNPs were found to be significantly associated with the risk of oral cancer and precancerous lesions

  3. rs909253 in LTA was identified to be significantly associated with ankylosing spondylitis susceptibility in this study population, but no significant association was found between ankylosing spondylitis risk and LTA rs2239704 or rs2229094

  4. study showed that heterozygous variant (AG) genotype of TNF-beta was associated with persistent primary immune thrombocytopenia, when compared with controls

  5. a positive correlation of HLA-DRB1 (显示 HLA-DRB1 蛋白)*12 and a negative correlation of HLA-DRB1 (显示 HLA-DRB1 蛋白)*13 with younger patientsTNFb4 allele's negative association with older patients displaying higher PSA (显示 PLAG1 蛋白) levels, higher GS and positive surrounding tissue involvement; positive association of TNFb5 allele for both older and younger patients

  6. the present study suggests LTa +252G as a risk alleles for disease susceptibility associated with higher serum levels of LTa and concomitant discrete clinical features among Indian systemic lupus erythematosus patients in India

  7. this study shows that TNF (显示 TNF 蛋白)-b is elevated in wound exudates of patients with hidradenitis suppurativa

  8. LTA -804C/A gene polymorphism is not found to be associated with the susceptibility of ischemic stroke in both Asian as well as in Caucasian population.

  9. After multivariable analysis TNF-alpha (显示 TNF 蛋白) polymorphism showed no consistent association with leukemia. CONCLUSIONS: This meta-analysis suggests that the LT-alpha +252 AA polymorphism is associated with the risk of leukemia

  10. Tumor Necrosis Factor (显示 TNF 蛋白) and Lymphotoxin (显示 LTB 蛋白) in Regulation of Intestinal Inflammation.



The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with LTA

  • lymphotoxin A (Lta)
  • lymphotoxin alpha (LTA)
  • lymphotoxin alpha (Lta)
  • lymphotoxin alpha (TNF superfamily, member 1) (LTA)
  • hlb382 蛋白
  • LT 蛋白
  • LT-alpha 蛋白
  • LT-[a] 蛋白
  • LTalpha 蛋白
  • Ltx 蛋白
  • LT[a] 蛋白
  • TNF-beta 蛋白
  • TNFB 蛋白
  • TNFSF1 蛋白
  • Tnfsf1b 蛋白

Protein level used designations for Lymphotoxin-alpha 蛋白 (LTA)

TNF beta , lymphotoxin alpha , lymphotoxin-alpha , tumor necrosis factor ligand superfamily member 1 , LT-alpha , TNF superfamily, member 1 , TNF-beta , tumor necrosis factor beta , lymphotoxin A , lymphotoxin alpha (TNF superfamily, member 1) , Lymphotoxin-alpha , tumour necrosis factor beta , ATP-binding cassette, sub-family F (GCN20), member 1

16992 Mus musculus
4049 Homo sapiens
25008 Rattus norvegicus
607183 Canis lupus familiaris
280845 Bos taurus
407742 Sus scrofa
100328931 Oryctolagus cuniculus
101123078 Ovis aries
494185 Pan troglodytes
715425 Macaca mulatta
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