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The HLA-DRB1 (显示 HLA-DRB1 ELISA试剂盒)*15:01 allele was confirmed to be linked to multiple sclerosis disease in an Italy family.
A total of 39 HLA-A, 66 HLA-B and 47 HLA-DRB1 (显示 HLA-DRB1 ELISA试剂盒) alleles were identified.
In white European people, antithyroid drug-induced agranulocytosis was associated with HLA-B*27:05 and with other SNPs on chromosome 6.
Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection
we found for the fi rst time an association between HLA genes and 25OHD concentration. Our results will need to be con fi rmed in a larger sample and preferably with more extensive HLA genotyping (in particular, HLA-A and HLA-C alleles).
These data implicate the prevalent African allele HLA-B*53:01 in the immunopathogenesis of raltegravir-induced DRESS syndrome.
results demonstrate that HIV-1 Nef's inferior ability to downregulate MHC-B compared to that of MHC-A is conserved across primate lentiviruses and suggest that this property influences antiviral cellular immune responses.
Three new HLA class I alleles, HLA-A*02:620, HLA-B*27:150 and HLA-B*07:05:01:02, were described in the Spanish Caucasoid population
Genetically, the strong primary sclerosing cholangitis (PSC) risk factors HLA-B*08 and DRB1 (显示 RBM45 ELISA试剂盒)*03 were more prevalent in Antineutrophil cytoplasmic antibodies (ANCA) -positive than -negative patients. In UC patients without liver disease, HLA-DRB1 (显示 HLA-DRB1 ELISA试剂盒)*03 was more prevalent in pANCA-positive compared with -negative patients.Antineutrophil cytoplasmic antibodies identified PSC patients with clinical and genetic characteristics.
The goal of this study was to evaluate the impact of EHR point-of-care tools on medical record documentation of genetic testing care processes for the common HFE mutations, a thrombophilia panel, and HLA-B27.
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
major histocompatibility complex, class I, B
, HLA class I histocompatibility antigen, B alpha chain
, MHC Class I HLA heavy chain
, MHC HLA-B cell surface glycoprotein
, MHC HLA-B transmembrane glycoprotein
, MHC class I antigen GN00104
, MHC class I antigen HLA-B heavy chain
, MHC class I antigen SHCHA
, leukocyte antigen class I-B
, lymphocyte antigen