SURF1 蛋白 (SURF1)产品概述

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Surfeit 1 蛋白 (SURF1)
在www.antibodies-online.cn可供10 Surfeit 1 (SURF1) 蛋白的5不同的供货商。 再加上,我们可以发SURF1 抗体 (31)SURF1 试剂盒 (1)和数多这个蛋白质的别的产品。 总共48 SURF1产品已列进来了。
别名:
0610010F23Rik, Ab1-205, BcDNA:GH23574, CG9943, Dmel\\CG9943, GB14201, im:6898613, Surf-1, SURF1, SURFEIT 1, zgc:158646
列出全部蛋白 基因 基因ID UniProt
SURF1 6834 Q15526
SURF1 64463 Q9QXU2
SURF1 20930 P09925

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引用最多的SURF1 蛋白

  1. Human SURF1 Protein expressed in Escherichia coli (E. coli) - ABIN666926 : Péquignot, Dey, Zeviani, Tiranti, Godinot, Poyau, Sue, Di Mauro, Abitbol, Marsac: Mutations in the SURF1 gene associated with Leigh syndrome and cytochrome C oxidase deficiency. in Human mutation 2001 (PubMed)
    Show all 2 references for 666926

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Human Surfeit 1 (SURF1) interaction partners

  1. Mutations in the SURF1 gene are a cause of Charcot-Marie-Tooth disease.

  2. This study suggested that hypertrophic olivary degeneration on magnetic resonance imaging in mitochondrial syndromes associated with POLG (显示 POLG 蛋白) and SURF1 mutations.

  3. sequenced the SURF1 gene and identified two heterozygous mutations; c.49+1 G>T and c.752_753del in Case 1, and homozygous c.743 C>A in Case 2

  4. Study identified 21 patients with clinical features of Leigh syndrome who are either homozygous or compound heterozygous for SURF1 mutations.

  5. Analysis of fibroblast cell lines from 9 patients with SURF1 mutations revealed a 70% decrease of the COX (显示 COX8A 蛋白) complex content to be associated with 32-54% upregulation of respiratory chain complexes I, III and V and accumulation of Cox5a (显示 COX5A 蛋白) subunit.

  6. Analysis of mutations in the SURF1 homolog Shy1 revealed Coa4, a new member of the cytochrome oxidase assembly factor family.

  7. Three novel mutations of the SURF-1 gene were identified in Japanese patients with cytochrome c (显示 CYCS 蛋白) oxidase deficiency; loss of function of the SURF-1 protein; cytochrome c (显示 CYCS 蛋白) oxidase activity was decreased to less than 20% of the control mean.

  8. new missense mutation of 574C>T in the SURF1 gene in Leigh's syndrome

  9. Two novel pathogenic SURF1 mutations have been identified in a patient with Leigh syndrome.

  10. Mutations in the nuclear SURF1 gene are specifically associated with cytochrome c (显示 CYCS 蛋白) oxidase (COX (显示 COX8A 蛋白))-deficient Leigh syndrome. MR imaging abnormalities in three children with this condition involved the brain.

Mouse (Murine) Surfeit 1 (SURF1) interaction partners

  1. These findings suggest that Surf1 deficiency-induced metabolic alterations may have positive effects on brain function.

  2. The expression of peroxisome proliferator-activated receptor gamma-coactivator 1-alpha (PGC-1alpha) mRNA and protein was up-regulated in white adipose tissue from Surf1-/- mice, and the expression of PGC-1alpha target genes

  3. Compared to wild type (WT) preparations Surf1 knockout preparations had a higher baseline respiratory frequency and abnormal responses to hypoxia and hypercapnia that involved both respiratory frequency and motor nerve discharge pattern.

  4. murine Surf1 protein (Surf1p) has a function specifically related to cytochrome c (显示 CYCS 蛋白) oxidase

  5. Prolonged lifespan and complete protection from Ca(2 (显示 CA2 蛋白)+)-dependent neurotoxicity induced by kainic acid in Surf-1 knockout mice.

蛋白简介SURF1

蛋白简介

This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency.

Alternative names and synonyms associated with SURF1

  • Surfeit 1 (Surf1)
  • surfeit 1 (Surf1)
  • surfeit 1 (SURF1)
  • surfeit 1 (surf1)
  • surfeit gene 1 (Surf1)
  • Surfeit locus 1 cytochrome c oxidase biogenesis protein (SURF1)
  • 0610010F23Rik 蛋白
  • Ab1-205 蛋白
  • BcDNA:GH23574 蛋白
  • CG9943 蛋白
  • Dmel\\CG9943 蛋白
  • GB14201 蛋白
  • im:6898613 蛋白
  • Surf-1 蛋白
  • SURF1 蛋白
  • SURFEIT 1 蛋白
  • zgc:158646 蛋白

Protein level used designations for Surfeit 1 蛋白 (SURF1)

CG9943-PA , Surf1-PA , surfeit 1 , surfeit locus protein 1 , surfeit protein

GENE ID SPECIES
44498 Drosophila melanogaster
413781 Apis mellifera
480681 Canis lupus familiaris
557970 Danio rerio
693110 Bombyx mori
6834 Homo sapiens
64463 Rattus norvegicus
417157 Gallus gallus
20930 Mus musculus
821310 Arabidopsis thaliana
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