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FOXM1 may play a central role in the skp2-cdk1 (显示 CDK1 ELISA试剂盒) loop driving tumor progression.
This study is the first to identify the roles of FOXM1 in drug efflux and paclitaxel resistance by regulating the gene transcription of abcc5 (显示 ABCC5 ELISA试剂盒), one of the ABC (显示 ABCB6 ELISA试剂盒) transporters. Small molecular inhibitors of FOXM1 or ABCC5 (显示 ABCC5 ELISA试剂盒) have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma (NPC (显示 NPC1 ELISA试剂盒))patients.
Data suggest that forkhead box M1 (FOXM1) expression is biomarker, and its inhibition is a potential treatment option for synovial sarcoma (SS).
The crucial role of FOXM1 and STMN1 (显示 STMN1 ELISA试剂盒) in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 (显示 STMN1 ELISA试剂盒) and FOXM1 in NSCLC cells.
There was no significant change in FoxM1 mRNA expression with or without FDI (显示 FDX1 ELISA试剂盒)-6 treatment.
study demonstrates that USP5 (显示 USP5 ELISA试剂盒) plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 (显示 USP5 ELISA试剂盒) being a potential therapeutic approach against pancreatic ductal adenocarcinoma
O-GlcNAcylation is a central component linking metabolism to invasion and metastasis via an SIRT1 (显示 SIRT1 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒)/FOXM1 axis.
Results has uncovered a previous unknown positive feedback loop between AURKA (显示 AURKA ELISA试剂盒) and FOXM1 that promotes breast cancer stem cells (BCSCs) phenotypes and drug resistance. It showed that nuclear AURKA (显示 AURKA ELISA试剂盒) is recruited by FOXM1 to transactivate the expression of target genes, which also include FOXM1, whereas AURKA (显示 AURKA ELISA试剂盒) itself is also a downstream transcriptional target of FOXM1.
The FOXM1 is a negative regulator of CRY2 (显示 CRY2 ELISA试剂盒) in breast cancer via enhancing methylation in CRY2 (显示 CRY2 ELISA试剂盒) promoter and its high expression is an independent predictor of favorable MR-free survival in ER+ breast cancer patients.
Knockdown of forkhead Box M1 (FoxM1) reduced Prx (显示 PRDX6 ELISA试剂盒) II levels in H-ras (显示 HRAS ELISA试剂盒)(G12V)-hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) cells, indicating FoxM1 as a direct transcription factor of Prx (显示 PRDX6 ELISA试剂盒) II in HCC (显示 FAM126A ELISA试剂盒).
YAP (显示 YAP1 ELISA试剂盒) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (显示 TNNI3 ELISA试剂盒) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (显示 INS ELISA试剂盒)-FoxM1/PLK1 (显示 PLK1 ELISA试剂盒)/CENP-A (显示 CENPA ELISA试剂盒) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (显示 EGF ELISA试剂盒) promotes FoxM1 expression through the ERK (显示 EPHB2 ELISA试剂盒) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (显示 PIK3CG ELISA试剂盒)-selective inhibitor and in Pik3cg (显示 PIK3CG ELISA试剂盒)(-/-) mice after LPS (显示 TLR4 ELISA试剂盒) challenge. Defective vascular repair in Pik3cg (显示 PIK3CG ELISA试剂盒)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (显示 HOXA10 ELISA试剂盒) and cyclin D3 (显示 CCND3 ELISA试剂盒).
FOXM1 and CENPF (显示 CENPF ELISA试剂盒) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (显示 TP53 ELISA试剂盒) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
MicroRNA-802 suppresses breast cancer proliferation through down-regulation of FoxM1.
FoxM1 expression correlates with proliferation, invasion and migration in mouse hepatocellular carcinoma cell lines.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix