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TAR DNA Binding Protein (TARDBP) ELISA试剂盒产品概述

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TAR DNA Binding Protein ELISA试剂盒 (TARDBP)
在www.antibodies-online.cn可供31 TAR DNA Binding Protein (TARDBP) ELISA试剂盒的11不同的供货商。 再加上,我们可以发TAR DNA Binding Protein 抗体 (236)TAR DNA Binding Protein 蛋白 (14)和数多这个蛋白质的别的产品。 总共296 TAR DNA Binding Protein产品已列进来了。
别名:
1190002A23Rik, ALS10, C85084, DKFZp459I2127, tardbp, TDP-43, Tdp43, wu:fb77f02, wu:fc52g10
list all ELISA KIts 基因 基因ID UniProt
TARDBP 23435 Q13148
TARDBP 230908 Q921F2
TARDBP 298648  

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适于 TAR DNA Binding Protein 相互作用对的更多 ELISA 试剂盒

Human TAR DNA Binding Protein (TARDBP) interaction partners

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. Mutant C9ORF72 impairs mitochondria activity in a different and opposite manner compared to mutant TDP-43. TARDBP and C9ORF72 mutations might trigger cell death by impairing not only RNA metabolism, but also mitochondria activity in ALS (显示 IGFALS ELISA试剂盒)/FTD (显示 FTL ELISA试剂盒) neurons since their mitochondrial energetic metabolism depends mainly on oxidative phosphorylation.

  3. 14-3-3 eta (显示 YWHAH ELISA试剂盒) isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis.

  4. Pathological TAR-DNA binding protein 43 (TDP-43) is cleaved into two major groups of fragments of approximately 35-, approximately 25-kDa, and the truncation at Arg208 completely eliminates the intrinsic ability of RNA recognition motif RRM2 (显示 RRM2 ELISA试剂盒) to fold.

  5. TDP-43 dual phosphorylation by MEK, at threonine 153 and tyrosine 155 (p-T153/Y155), was dramatically increased by the heat shock response (HSR) in human cells.

  6. Taken together, inhibition of nuclear import of TDP-43 by cytoplasmic poly-GA inclusions causally links the two main aggregating proteins in C9orf72 amyotrophic lateral sclerosis /lobar degeneration pathogenesis.

  7. The aim of this review will be to provide a general overview of TDP-43 and FUS/TLS (显示 FUS ELISA试剂盒) proteins and to highlight their physiological functions--{REVIEW}

  8. Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in amyotrophic lateral sclerosis is caused by abnormal autoregulation of TDP-43.

  9. Findings suggest a mechanism in which retrotransposable element (RTE) activity contributes to neurodegeneration in TAR DNA-binding protein 43 (TDP-43)-mediated diseases such as Amyotrophic lateral sclerosis (ALS (显示 IGFALS ELISA试剂盒)) and frontotemporal lobar degeneration (FTLD).

  10. Possible role of deregulated DNA binding function of TDP-43 in ALS.

Mouse (Murine) TAR DNA Binding Protein (TARDBP) interaction partners

  1. These findings suggest that TDP-43 promotes tau exon 10 inclusion and 4R-tau expression and that disease-related changes of TDP-43, truncations and mutations, affect its function in tau exon 10 splicing, possibly because of TDP-43 mislocalization to the cytoplasm.

  2. this study suggests hemizygous TDP-43(M337V) mice as a useful animal model to study TDP-43 toxicity and further consolidates mitochondrial TDP-43 as a novel therapeutic target for TDP-43-linked neurodegenerative diseases.

  3. demonstrated that the levels of HSF1 (显示 HSF1 ELISA试剂盒) and heat shock proteins are significantly reduced in affected neuronal tissues from a TDP-43 transgenic mouse model of amyotrophic lateral sclerosis and patients with sporadic amyotrophic lateral sclerosis.

  4. The present study identified USP7 (显示 USP7 ELISA试剂盒) and TDP-43 as the regulators of CRY1 (显示 CRY1 ELISA试剂盒) and CRY2 (显示 CRY2 ELISA试剂盒), underscoring the significance of the stability control process of CRY (显示 CRY2 ELISA试剂盒) proteins for period determination in the mammalian circadian clockwork.

  5. TDP-43 functions within a network of hnRNP (显示 HNRNPH2 ELISA试剂盒) proteins to inhibit the production of a truncated human SORT1 (显示 SORT1 ELISA试剂盒) receptor.

  6. Data demonstrate the existence of a physiological decrease of TDP-43/TBPH levels with aging in brain tissue both in wild-type mice and flies, showing that it is an evolutionary conserved phenomenon

  7. This study demonistrated that proprioceptive nerve endings in muscles revealed early and alterations at Ia/II proprioceptive nerve endings in muscle spindles and in the absence of alterations in alpha-motor axons in TDP43(A315T) transgenic mice.

  8. UBQLN2 (显示 UBQLN2 ELISA试剂盒) dysregulation in neurons can drive NF-kappaB (显示 NFKB1 ELISA试剂盒) activation and cytosolic TDP-43 aggregation.

  9. These findings demonstrate a role for PABPN1 (显示 PABPN1 ELISA试剂盒) in rescuing several cytopathological features of TDP-43 proteinopathy by increasing the turnover of pathologic proteins.

  10. identifies DDX58 (显示 DDX58 ELISA试剂盒) and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1

Zebrafish TAR DNA Binding Protein (TARDBP) interaction partners

  1. Data indicate a method for site-directed single nucleotide editing in two disease-related genes, DNA binding protein (显示 CNBP ELISA试剂盒) tardbp and RNA binding protein fus (显示 FUS ELISA试剂盒).

  2. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

  3. TARDBP and FUS (显示 FUS ELISA试剂盒) act in a pathogenic pathway that is independent of SOD1 (显示 SOD1 ELISA试剂盒).

TAR DNA Binding Protein (TARDBP) 抗原简介

Antigen Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.

Alternative names and synonyms associated with TAR DNA Binding Protein (TARDBP)

  • TAR DNA binding protein (TARDBP) Elisa Kit
  • Tardbp protein (tardbp) Elisa Kit
  • TAR DNA binding protein (tardbp) Elisa Kit
  • TAR DNA binding protein (Tardbp) Elisa Kit
  • TAR DNA-binding protein 43-like (LOC100621383) Elisa Kit
  • 1190002A23Rik Elisa Kit
  • ALS10 Elisa Kit
  • C85084 Elisa Kit
  • DKFZp459I2127 Elisa Kit
  • tardbp Elisa Kit
  • TDP-43 Elisa Kit
  • Tdp43 Elisa Kit
  • wu:fb77f02 Elisa Kit
  • wu:fc52g10 Elisa Kit

Protein level used designations for TARDBP

TAR DNA binding protein , TAR DNA-binding protein 43 , Tardbp protein , TDP-43 , TAR DNA-binding protein-43

GENE ID SPECIES
100174676 Pongo abelii
457942 Pan troglodytes
713860 Macaca mulatta
778772 Ciona intestinalis
100051482 Equus caballus
100602228 Nomascus leucogenys
380329 Xenopus laevis
419453 Gallus gallus
23435 Homo sapiens
478234 Canis lupus familiaris
540632 Bos taurus
230908 Mus musculus
298648 Rattus norvegicus
325052 Danio rerio
100718595 Cavia porcellus
101114038 Ovis aries
100621383 Sus scrofa
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