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These results provide evidence that CDX2 plays an essential role in functional trophectoderm formation during primate embryonic development.
our findings demonstrated that MDR1 expression is regulated by CDX2 and is related to drug resistance in ovarian mucinous adenocarcinoma.
The data presented provide a novel insight into how CDX2 is implicated in the transcriptional regulation of LAMC2 (显示 LAMC2 ELISA试剂盒) in intestinal epithelial cells, a function that is impaired during mucosal inflammation where a high level of TNF-alpha (显示 TNF ELISA试剂盒) is present.
Cytapheresis might induce CDX2 expression without affecting the cell proliferation, thus resulting in mucosal healing with goblet cell restoration.
SOX2 (显示 SOX2 ELISA试剂盒) expression induces a cellular stem cell state in human colorectal cancer (CRC (显示 CALR ELISA试剂盒)) with a decreased expression of CDX2. Furthermore, a down-regulated expression of CDX2 results in a poor patient prognosis in CRC (显示 CALR ELISA试剂盒).
A small subset (5%) of hepatocellular carcinomas are CDX2 positive.
A new organ culture system for adult murine oesophagus is described. Using this, Cdx2 and HNF4alpha (显示 HNF4A ELISA试剂盒) were ectopically expressed by adenoviral infection. We demonstrate the expression of CDX2 and HNF4alpha (显示 HNF4A ELISA试剂盒) in human biopsy samples.
Colon cancer cells expressing CDX2 are less deformable, a feature that has been shown to correlate with poor metastatic potential.
Results show that CDX2 and Fbw7 (显示 FBXW7 ELISA试剂盒) expression is inversely correlated during colon cell differentiation and that CDX2 expression is regulated by Fbw7 (显示 FBXW7 ELISA试剂盒) in a GSK3b (显示 GSK3b ELISA试剂盒)-dependent manner.
Aberrant DNA methylation (显示 HELLS ELISA试剂盒) of SOX2 (显示 SOX2 ELISA试剂盒) and CDX2 genes contributes to the development of IM. Notably, SOX2 (显示 SOX2 ELISA试剂盒) may play a role in establishing and maintaining the methylation status of the CDX2 gene in gastric tissues and cells.
Strong expression of CDX2 was demonstrated only in the mature colonic epithelium of teratomas in both primary and metastatic germ cell tumors of the testis.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
showed novel molecular regulation of CDX2 on Oct4 (显示 POU5F1 ELISA试剂盒), and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 (显示 POU5F1 ELISA试剂盒) in embryo of mammals other than mouse
including Wnt (显示 WNT2 ELISA试剂盒) and Fgf pathway components active in the axial progenitor niche. Our data demonstrate that integration of the Cdx (显示 CDX1 ELISA试剂盒)/Hox (显示 MSH2 ELISA试剂盒) and T Brachyury (显示 TBX1 ELISA试剂盒) transcriptional networks controls differential axial growth during vertebrate trunk elongation
Cdx (显示 CDX1 ELISA试剂盒) members interact with the SWI (显示 SMARCA1 ELISA试剂盒)-SNF (显示 SNRPA ELISA试剂盒) complex and make direct contact with Brg1 (显示 SMARCA4 ELISA试剂盒), a catalytic member of SWI (显示 SMARCA1 ELISA试剂盒)-SNF (显示 SNRPA ELISA试剂盒). Both Cdx2 and Brg1 (显示 SMARCA4 ELISA试剂盒) co-occupy a number of Cdx (显示 CDX1 ELISA试剂盒) target genes, and both factors are necessary for transcriptional regulation of such targets. Finally, Cdx2 and Brg1 (显示 SMARCA4 ELISA试剂盒) occupancy occurs coincident with chromatin remodeling at some of these loci.
The authors identify a Cdx2-responsive segment of HoxA, immediately 5' to the recently defined regulatory domain orchestrating initial transcription of the first Hox (显示 MSH2 ELISA试剂盒) gene.
Cdx1 (显示 CDX1 ELISA试剂盒)-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac (显示 ADCY10 ELISA试剂盒) and a block in hematopoietic differentiation from yolk sac (显示 ADCY10 ELISA试剂盒)-derived cells in culture.
this study shows that Aloe vera (显示 IGF2BP3 ELISA试剂盒) gel suppresses colitis-related colon carcinogenesis via increased expression of CDX-2, a tumor suppressor in colorectal cancer
Results point out the complex interplay between the DSB DNA repair activity and the homeoproteins HoxB7 (显示 HOXB7 ELISA试剂盒) and Cdx2 in colon cancer cells.
CDX2 is required for proliferation and differentiation of intestinal stem cells. Direct CDX2 targets in ISCs (显示 NFS1 ELISA试剂盒) may be activated or repressed.
cells in preimplantation embryos that localized in an initial outer position initiated the expression of Cdx2. cells that changed their position from an outer to an inner position downregulated Cdx2 expression and contributed to the inner cell mass.
findings illuminated a role for NOD1 (显示 NOD1 ELISA试剂盒) signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells
results thus indicate that CDX2 is not required for TE formation during bovine development; nevertheless, it is necessary for maintaining TE integrity.
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis.
caudal type homeobox 2
, caudal type homeobox transcription factor 2
, caudal type homeo box transcription factor 2
, homeobox protein CDX-2
, caudal-type homeobox protein 2
, caudal type homeo box 2
, caudal-type homeobox transcription factor 2