MDM2 (MDM2) ELISA试剂盒产品概述

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Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) ELISA试剂盒 (MDM2)
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别名:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all ELISA KIts 基因 基因ID UniProt
MDM2 4193 Q00987
大鼠 MDM2 MDM2 314856  
MDM2 17246 P23804

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引用最多的MDM2 ELISA试剂盒

  1. Human MDM2 ELISA Kit for Sandwich ELISA - ABIN422415 : Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016 (PubMed)

适于 MDM2 相互作用对的更多 ELISA 试剂盒

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. a novel molecular mechanism which, in silico, is capable of triggering p53 (显示 TP53 ELISA试剂盒) oscillations. The mechanism that is based on Mdm2's dual regulation of p53 (显示 TP53 ELISA试剂盒) can provide mechanistic insights into an excitability of the p53 (显示 TP53 ELISA试剂盒) network, thus it contributes to understanding of variability of p53 (显示 TP53 ELISA试剂盒) dynamics in response to single and double strand breaks.

  2. Histologically low-grade and relatively low-grade cases of extraskeletal osteosarcoma are not always associated with MDM2 amplification. ESOS cases with MDM2 amplification could be high grade.

  3. Disturbed p53 (显示 TP53 ELISA试剂盒)-MDM2 feedback loop contributing to the pathogenesis of thoracic aortic dissection may be linked to TRIM25 (显示 TRIM25 ELISA试剂盒) overexpression.

  4. These results identify a novel function for FKBP12 (显示 FKBP1A PLURAL_@45135@) in downregulating MDM2, which directly enhances sensitivity of cancer cells to chemotherapy and nutlin-3 treatment.

  5. Although uncommon, MDM2 labeling is seen in a subset of fat-predominant angiolipomas and is a potential diagnostic pitfall in the evaluation of fatty tumors of the retroperitoneum.

  6. high-level MDM2 expression is needed in order to perform a critical p53 (显示 TP53 ELISA试剂盒)-independent function and may obviate the need for genomic alterations to the p53 (显示 TP53 ELISA试剂盒) pathway during retinoblastoma tumorigenesis.

  7. p16 in combination with MDM2 and CDK4 (显示 CDK4 ELISA试剂盒) immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  8. MDM2 gene single nucleotide polymorphism are associated with apoptotic signaling and smoking-related emphysematous changes in lungs.

  9. we determined the molecular mechanism responsible for IER3 (显示 IER3 ELISA试剂盒) degradation, involving a ternary complex of IER3 (显示 IER3 ELISA试剂盒), MDM2 and FHL2 (显示 FHL2 ELISA试剂盒), which may contribute to cervical tumor growth. Furthermore, we demonstrated that FHL2 (显示 FHL2 ELISA试剂盒) serves as a scaffold for E3 ligase and its substrate during the ubiquitination reaction, a function that has not been previously reported for this protein

  10. NPM1 (显示 NPM1 ELISA试剂盒) downregulation by P-STAT5 (显示 STAT5A ELISA试剂盒) is mediated by impairing the BRCA1-BARD1 (显示 BARD1 ELISA试剂盒) ubiquitin ligase, which controls the stability of NPM1 (显示 NPM1 ELISA试剂盒). In turn, decreased NPM1 (显示 NPM1 ELISA试剂盒) levels led to suppression of p53 (显示 TP53 ELISA试剂盒) expression, resulting in enhanced cell survival.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (显示 TP53 ELISA试剂盒)-dependent apoptosis of Theileria parva (显示 PARVA ELISA试剂盒)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (显示 PARVA ELISA试剂盒), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (显示 PARVA ELISA试剂盒)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (显示 MDM4 ELISA试剂盒) caused dramatic accumulation of mutant p53 protein (显示 TP53 ELISA试剂盒).

  2. Together with p53 (显示 TP53 ELISA试剂盒), provides an experimental model for characterizing drugs and genes that affect p53 (显示 TP53 ELISA试剂盒) signaling.

  3. Data show that liver-specific expression of p53 (显示 TP53 ELISA试剂盒)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. In Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (显示 MEF2C ELISA试剂盒) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (显示 TSFM ELISA试剂盒) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (显示 FMR1 ELISA试剂盒) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (显示 DLG4 ELISA试剂盒) ubiquitination, degradation and synapse elimination in Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons.

  2. MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (显示 TP53 ELISA试剂盒) overexpression-related cell death.

  3. The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.

  4. MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (显示 TP53 ELISA试剂盒)-independent pathway dependant on Notch1 (显示 NOTCH1 ELISA试剂盒) ubiquitination and proteasome degradation.

  5. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (显示 TP53 ELISA试剂盒)/Mdm2-Mdm4 (显示 MDM4 ELISA试剂盒) via a RING domain-mediated biochemical mechanism.

  6. both MDM2 and MDMX (显示 MDM4 ELISA试剂盒) deletion-caused pancreatic defects are completely rescued by loss of p53 (显示 TP53 ELISA试剂盒), verifying the crucial role of the MDM2 and/or MDMX (显示 MDM4 ELISA试剂盒) in regulating p53 (显示 TP53 ELISA试剂盒) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  7. Vif (显示 BTG1 ELISA试剂盒) stabilization by CBFbeta (显示 CBFB ELISA试剂盒) is mainly caused by impairing MDM2-mediated degradation.

  8. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  9. we failed to detect any increase in p53 (显示 TP53 ELISA试剂盒) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (显示 TP53 ELISA试剂盒)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (显示 MDM4 ELISA试剂盒), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  10. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (显示 TP53 ELISA试剂盒).

MDM2 抗原简介

Antigen Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) Elisa Kit
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) Elisa Kit
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2) Elisa Kit
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) Elisa Kit
  • p53 E3 ubiquitin protein ligase (Mdm2) Elisa Kit
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) Elisa Kit
  • transformed mouse 3T3 cell double minute 2 (Mdm2) Elisa Kit
  • 1700007J15Rik Elisa Kit
  • AA415488 Elisa Kit
  • ACTFS Elisa Kit
  • hdm2 Elisa Kit
  • HDMX Elisa Kit
  • Mdm-2 Elisa Kit
  • zgc:109834 Elisa Kit

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPECIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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