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Human MDM2 ELISA Kit for Sandwich ELISA - ABIN422415
Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016
MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for osteosarcoma susceptibility in different populations [review and meta-analysis]
The MDM2 T/T genotype was predictive of poorer survival in a Japanese population of lung adenocarcinoma patients.
Blocking the MDM2 protein-XIAP (显示 XIAP ELISA试剂盒) mRNA interaction reduces MDM2 and XIAP (显示 XIAP ELISA试剂盒) levels and activates p53 (显示 TP53 ELISA试剂盒).
Patients with alterations in TP53 (显示 TP53 ELISA试剂盒) or MDM2 had a reduced progression-free survival, and TP53 (显示 TP53 ELISA试剂盒)/MDM2 alterations were an independent predictor of disease progression after cisplatin-based chemotherapy. TP53 (显示 TP53 ELISA试剂盒) alterations were identified in 72% of patients with primary mediastinal nonseminoma, which may explain their inferior outcomes.
our findings indicate the functional role of HBx in regulating the stem-like properties of OV6(+) CSCs in HCC (显示 FAM126A ELISA试剂盒) through the MDM2/CXCL12 (显示 CXCL12 ELISA试剂盒)/CXCR4 (显示 CXCR4 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling axis, and identify HBx, MDM2, CXCR4 (显示 CXCR4 ELISA试剂盒) and OV6 as a novel prognostic pathway and potential therapeutic targets for patients with HBV-related HCC (显示 FAM126A ELISA试剂盒) patients
This study suggests that MDM2 activates Smad (显示 SMAD1 ELISA试剂盒) pathway to promote EMT (显示 ITK ELISA试剂盒) in ovarian cancer metastasis.
The MDM2 SNP309 in retinal pigment epithelial cells enhances their potential of proliferative vitreoretinopathy pathogenesis.
High MDM2 expression is associated with acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
mutant Mdm2 was unable to rescue a p53 (显示 TP53 ELISA试剂盒)-induced apoptotic phenotype.
High MDM2 expression is associated with Sjogren's syndrome.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (显示 TP53 ELISA试剂盒)-dependent apoptosis of Theileria parva (显示 PARVA ELISA试剂盒)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (显示 PARVA ELISA试剂盒), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (显示 PARVA ELISA试剂盒)-infected lymphocytes
Data indicate that knockdown of the Mdm2 and Mdm4 (显示 MDM4 ELISA试剂盒) caused dramatic accumulation of mutant p53 protein (显示 TP53 ELISA试剂盒).
Together with p53 (显示 TP53 ELISA试剂盒), provides an experimental model for characterizing drugs and genes that affect p53 (显示 TP53 ELISA试剂盒) signaling.
Data show that liver-specific expression of p53 (显示 TP53 ELISA试剂盒)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
the existence of an unusual functional interplay between STATs and CREB (显示 CREB1 ELISA试剂盒) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (显示 TP53 ELISA试剂盒). Moreover, results suggest that p73 (显示 ARHGAP24 ELISA试剂盒) compensates for loss of p53 (显示 TP53 ELISA试剂盒).
In Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (显示 MEF2C ELISA试剂盒) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (显示 TSFM ELISA试剂盒) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (显示 FMR1 ELISA试剂盒) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (显示 DLG4 ELISA试剂盒) ubiquitination, degradation and synapse elimination in Fmr1 (显示 FMR1 ELISA试剂盒) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (显示 TP53 ELISA试剂盒) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
MDM2 is involved in fibroblast activation, mediating renal tubulointerstitial fibrosis via a p53 (显示 TP53 ELISA试剂盒)-independent pathway dependant on Notch1 (显示 NOTCH1 ELISA试剂盒) ubiquitination and proteasome degradation.
These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (显示 TP53 ELISA试剂盒)/Mdm2-Mdm4 (显示 MDM4 ELISA试剂盒) via a RING domain-mediated biochemical mechanism.
both MDM2 and MDMX (显示 MDM4 ELISA试剂盒) deletion-caused pancreatic defects are completely rescued by loss of p53 (显示 TP53 ELISA试剂盒), verifying the crucial role of the MDM2 and/or MDMX (显示 MDM4 ELISA试剂盒) in regulating p53 (显示 TP53 ELISA试剂盒) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.
Vif (显示 BTG1 ELISA试剂盒) stabilization by CBFbeta (显示 CBFB ELISA试剂盒) is mainly caused by impairing MDM2-mediated degradation.
These results demonstrated a critical prosurvival role for MDM2 in the oocytes
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog