anti-GTPase NRas (NRAS) 抗体产品概述

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anti-GTPase NRas 抗体 (NRAS)
在www.antibodies-online.cn可供102 GTPase NRas (NRAS) 抗体的17不同的供货商。 再加上,我们可以发GTPase NRas 蛋白 (17)GTPase NRas 试剂盒 (6)和数多这个蛋白质的别的产品。 总共130 GTPase NRas产品已列进来了。
别名:
ALPS4, AV095280, fj99a10, H-RAS, HRAS, N-RAS, NRAS, NRAS1, NS6, wu:fj99a10, zgc:100761, zras-b1

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引用最多的anti-GTPase NRas 抗体

  1. Human Monoclonal GTPase NRas Primary Antibody for EIA, WB - ABIN781533 : Rocks, Peyker, Bastiaens: Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors. in Current opinion in cell biology 2006 (PubMed)
    Show all 3 references for 781533

  2. Human Polyclonal GTPase NRas Primary Antibody for IHC, ELISA - ABIN302138 : Thomas, Edmiston, Alexander, Millikan, Groben, Hao, Tolbert, Berwick, Busam, Begg, Mattingly, Ollila, Tse, Hummer, Lee-Taylor, Conway: Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 (PubMed)

  3. Human Monoclonal GTPase NRas Primary Antibody for WB - ABIN1882272 : Hall, Brown: Human N-ras: cDNA cloning and gene structure. in Nucleic acids research 1985 (PubMed)

  4. Human Polyclonal GTPase NRas Primary Antibody for FACS, IF - ABIN392152 : Smalley, Contractor, Nguyen, Xiao, Edwards, Muthusamy, King, Flaherty, Bosenberg, Herlyn, Nathanson: Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. in Cancer research 2008 (PubMed)

更多抗GTPase NRas的相互作用对抗体

Mouse (Murine) GTPase NRas (NRAS) interaction partners

  1. loss of one allele of Hras (显示 HRAS 抗体) increased the sensitivity of mice to this carcinogen, and this effect was further exacerbated by the loss of the second Hras (显示 HRAS 抗体) allele. However, loss of one or both alleles of Nras failed to alter tumor burden, either in the absence or presence of Hras (显示 HRAS 抗体), after exposure to urethane.

  2. Genetic inactivation of Ezh2 (显示 EZH2 抗体) or Eed (显示 EED 抗体) cooperates with NRASQ61K in leukemogenesis.

  3. Data indicate that S-phase kinase-associated protein 2 (SKP2) cooperates with N-Ras and AKT proto-oncogenes to promote hepatocarcinogenesis in vivo.

  4. Activated NRAS and aberrant Wnt (显示 WNT2 抗体) signaling conspire to drive congenital melanocytic nevus syndrome.

  5. a crucial role of RXRa (显示 RXRA 抗体) in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4 (显示 CDK4 抗体)(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 (显示 TP53 抗体) and PTEN (显示 PTEN 抗体)

  6. This work explains the curious predominance in human melanoma of mutations of codon 61 of NRAS over other oncogenic NRAS mutations. we show that physiologic expression of NRASQ61R, but not NRASG12D, drives melanoma formation.

  7. These data reveal the L. major-enhanced CD40-induced N-Ras activation as a novel immune evasion strategy and the potential for Ras isoform-targeted antileishmanial immunotherapy and immunoprophylaxis.

  8. NRAS expression is required for the proliferative advantage of human AML (显示 RUNX1 抗体) cell lines in vitro and for the maintenance of mouse Nras-mutant AML (显示 RUNX1 抗体) in vivo

  9. There was a nearly complete correspondence between the signaling pathways that were regulated by N-ras in immune cell types.

  10. Cbfbeta (显示 CBFB 抗体)-SMMHC (显示 MYH11 抗体) and Nras(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK (显示 MDK 抗体)/ERK (显示 EPHB2 抗体)/Bim (显示 BCL2L11 抗体) axis, and define Nras(LSL-G12D); Cbfb (显示 CBFB 抗体)(56M) mice as a valuable genetic model for the study of AML (显示 RUNX1 抗体) therapies.

Human GTPase NRas (NRAS) interaction partners

  1. NRAS mutations were present in 1.2% of primary papillary thyroid carcinomas, 1.3% of lymph node metastasis, and 14.3% of distant metastasis.

  2. Data suggest that isoform-specific sequences in the allosteric lobes of HRAS (显示 HRAS 抗体), KRAS, and NRAS have an impact on biocatalysis (kinetics of GTP (显示 AK3 抗体) hydrolysis) and interaction with c-Raf (显示 RAF1 抗体) kinase, which must be due to allosteric effects on dynamics and conformational states, given the identical active sites of these isoenzymes.

  3. NRAS(Q61R) immunohistochemistry is a highly sensitive and specific tool that is useful for differentiating follicular-patterned thyroid tumors.

  4. NRAS variants were identified in 2 cases with a lethal presentation of Noonan syndrome.

  5. Mutation in NRAS gene is associated with chronic myelomonocytic leukemia.

  6. Compared with newly diagnosed multiple myeloma, an increased prevalence of mutations in the Ras pathway genes KRAS, NRAS, and/or BRAF (显示 BRAF 抗体) (72%), as well as TP53 (显示 TP53 抗体) (26%), CRBN (显示 CRBN 抗体) (12%), and CRBN (显示 CRBN 抗体) pathway genes (10%) was observed.

  7. Our data suggest that testing for any RAS mutation is unlikely to change the clinical management of thyroid nodules that have indeterminate cytology

  8. Examination of clinical parameters of these tumors found those with APA (显示 ENPEP 抗体) of NRAS and c-JUN (显示 JUN 抗体) to be smaller and less proliferative

  9. Equilibrium dissociation constants were determined for the binding of HRAS, KRAS, NRAS and RRAS2 to the RAS binding (RB) domain of binding proteins.

  10. Studies indicate that RAS proteins were among the first oncogenes identified and are mutationally activated in 30% of all cancer types.

Zebrafish GTPase NRas (NRAS) interaction partners

  1. Although oncogenic NRAS expression alone was found to be insufficient to promote tumor formation, loss of functional p53 (显示 TP53 抗体) was found to collaborate with NRAS expression in the genesis of melanoma.

GTPase NRas (NRAS) 抗原简介

Antigen Summary

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Alternative names and synonyms associated with GTPase NRas (NRAS)

  • GTPase NRas (Tsp_01117) 抗体
  • African clawed frog N-ras (n-ras) 抗体
  • neuroblastoma ras oncogene (Nras) 抗体
  • neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS) 抗体
  • neuroblastoma RAS viral (v-ras) oncogene homolog (nras) 抗体
  • ALPS4 抗体
  • AV095280 抗体
  • fj99a10 抗体
  • H-RAS 抗体
  • HRAS 抗体
  • N-RAS 抗体
  • NRAS 抗体
  • NRAS1 抗体
  • NS6 抗体
  • wu:fj99a10 抗体
  • zgc:100761 抗体
  • zras-b1 抗体

Protein level used designations for anti-GTPase NRas (NRAS) 抗体

GTPase NRas , transforming protein N-Ras , neuroblastoma RAS viral (v-ras) oncogene homolog , N-ras oncogene , p21 protein , N-ras protein part 4 , v-ras neuroblastoma RAS viral oncogene homolog , ras p21 , N-ras oncogene p21 , etID18709.8 , neuroblastoma RAS viral oncogene-like protein , neuroblastoma ras oncogene , v-Ha-ras Harvey rat sarcoma viral oncogene homolog

GENE ID SPECIES
10905151 Trichinella spiralis
399446 Xenopus laevis
24605 Rattus norvegicus
18176 Mus musculus
100135584 Cavia porcellus
4893 Homo sapiens
403872 Canis lupus familiaris
30380 Danio rerio
419885 Gallus gallus
100739349 Sus scrofa
506322 Bos taurus
100174317 Pongo abelii
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