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This study showed that altered Pdx1 mRNA and protein levels in weaned male mutant beta-cells were tightly linked with hyperglycemia, decreased beta-cell proliferation, reduced beta-cell area, and altered expression of Pdx1-bound genes that are important in beta-cell replication, endoplasmic reticulum function, and mitochondrial activity.
These results suggest that Oc1 (显示 ONECUT1 ELISA试剂盒) and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Data suggest that Ad4BP (显示 NR5A1 ELISA试剂盒) plays role in regulation of intracellular NADPH (显示 FDXR ELISA试剂盒) concentration via transcription of Me1 (显示 ME1 ELISA试剂盒) and Mthfd2 (显示 MTHFD2 ELISA试剂盒) genes in adrenocortical cells. (Ad4BP (显示 NR5A1 ELISA试剂盒) = nuclear receptor subfamily 5 group A member 1 (显示 NR5A1 ELISA试剂盒); Me1 (显示 ME1 ELISA试剂盒) = malic enzyme 1 (显示 ME1 ELISA试剂盒); Mthfd2 (显示 MTHFD2 ELISA试剂盒) = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)
Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A)
PDX1 and ISL1 (显示 ISL1 ELISA试剂盒) regulation of insulin (显示 INS ELISA试剂盒) gene expression in pancreatic beta cells, was investigated.
WT1 (显示 WT1 ELISA试剂盒) is required for the lineage specification of both Sertoli and granulosa cells by repressing Sf1 (显示 SF1 ELISA试剂盒) expression. Without Wt1 (显示 WT1 ELISA试剂盒), the expression of Sf1 (显示 SF1 ELISA试剂盒) was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells.
Creating the Pdx1(DeltaAREAII) state after cells entered an insulin (显示 INS ELISA试剂盒)-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions.
The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.
Our data suggested that lipid accumulation in the Leydig cells of the 46,XY disorders of sex development phenotype with a steroidogenic factor 1 (显示 NR5A1 ELISA试剂盒) mutation is due, at least in part, to the suppression of steroidogenic acute regulatory protein (显示 STAR ELISA试剂盒) and CYP11A1 (显示 CYP11A1 ELISA试剂盒), and a resulting increase in unmetabolized cholesterol.
Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic
expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1
Efficiency of differentiation of Induced pluripotent stem cells to insulin (显示 INS ELISA试剂盒) producing cells can be increased by concurrent expression of PDX1 and NKX6.1 (显示 NKX6-1 ELISA试剂盒) during progenitor cells maturation.
Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.
Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb (显示 INHBB ELISA试剂盒) is identified as one factor mediating the proliferative effect of Pdx-1.
Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.
Pdx1 and MafA (显示 KLRG1 ELISA试剂盒) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA (显示 KLRG1 ELISA试剂盒) were significantly upregulated after a sleeve gastrectomy for morbid obesity.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2 (显示 SOX2 ELISA试剂盒)) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
The ERK (显示 EPHB2 ELISA试剂盒)-PDX-1 interaction in PANC-1 cells.
Foxo1 (显示 FOXO1 ELISA试剂盒) and PDX1 are colocalized in fetal pancreatic islets, suggesting they function in parallel in beta cells.
This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet beta cells.
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment
A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.
Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.
Report pancreatic expression of Pdx-1 in pancreas.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
pancreatic and duodenal homeobox 1
, pancreas/duodenum homeobox protein 1
, adrenal 4-binding protein
, embryonal LTR-binding protein
, embryonal long terminal repeat-binding protein
, fushi tarazu 1 factor homolog
, fushi tarazu factor homolog 1
, steroid hormone receptor Ad4BP
, steroid hydroxylase positive regulator
, steroidogenic factor 1
, glucose-sensitive factor
, insulin promoter factor 1, homeodomain transcription factor
, insulin upstream factor 1
, islet/duodenum homeobox-1
, pancreatic-duodenal homeobox factor 1
, somatostatin transcription factor 1
, somatostatin-transactivating factor 1
, pancreatic and duodenum homeobox 1
, pancreatic duodenal homeobox gene 1
, islet/duodenum homeobox 1
, pancreatic and duodenal homeobox gene 1
, Insulin promoter factor 1
, insulin promotor factor 1
, somatostatin transactivating factor 1
, homeodomain protein PDX1
, homeodomain protein PDX-1
, Homeobox protein 8
, XlHbox 8 protein