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Rat (Rattus) IGFBP3 ELISA Kit for Sandwich ELISA - ABIN416321
Qin, Tian: Characterization of the specific and sustained GH1 expression induced by rAAV2/1 in normal adult male rats. in Molecular biology reports 2010
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Mouse (Murine) IGFBP3 ELISA Kit for Sandwich ELISA - ABIN625402
Obenauf, Zou, Ji, Vanharanta, Shu, Shi, Kong, Bosenberg, Wiesner, Rosen, Lo, Massagué: Therapy-induced tumour secretomes promote resistance and tumour progression. in Nature 2015
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Human IGFBP3 ELISA Kit for Sandwich ELISA - ABIN365320
Ayd?n, Demirkol, Ba?, Türko?lu, Kumral, Karaböcüo?lu, C?tak, Darendeliler: Evaluation of endocrine function in children admitted to pediatric intensive care unit. in Pediatrics international : official journal of the Japan Pediatric Society 2014
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insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 (显示 BMP4 ELISA试剂盒) in zebrafish embryos
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
this study identified several loci associated with circulating IGF-I (显示 IGF1 ELISA试剂盒) and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3 (显示 FOXO3 ELISA试剂盒)) and novel (ASXL2 (显示 ASXL2 ELISA试剂盒)) longevity-associated loci.
these findings suggest that IGFBP-3 suppresses transcription of EGR1 (显示 EGR1 ELISA试剂盒) and its target genes bFGF (显示 FGF2 ELISA试剂盒) and PDGF (显示 PDGFA ELISA试剂盒) through inhibiting IGF-1 (显示 IGF1 ELISA试剂盒)-dependent ERK (显示 EPHB2 ELISA试剂盒) and AKT (显示 AKT1 ELISA试剂盒) activation.
results indicate that hypoxia suppresses the osteogenic differentiation of mesenchymal stem cells via IGFBP3 up-regulation.
Data suggest that serum levels IGF-I (insulin-like growth factor I (显示 IGF1 ELISA试剂盒)) and IGFBP-3 (insulin-like growth factor binding protein 3) in pediatric patients with osteogenesis imperfecta (显示 COL1A2 ELISA试剂盒) (OI) and short statue are not different according to severity of OI or type of OI (patients with types 3 and 4 were investigated here); all patients had been treated with intravenous neridronate every 3 months for at least 2 years.
Meta-analysis suggests that for esophageal cancer, the low IGFBP-3 level is associated with high cancer risk, poor prognosis, and unfavorable tumor stage and metastasis. [meta-analysis]
Expression of IL-24 (显示 IL24 ELISA试剂盒) and IGFBP-3 significantly suppressed prostate cancer tumor growth in vivo.
Blood IGFBP3 was lower in Black participants compared to Whites.
The microRNA-125b level promotes invasive ability in p53 (显示 TP53 ELISA试剂盒)-mutated cells via PI3K (显示 PIK3CA ELISA试剂盒)/AKT (显示 AKT1 ELISA试剂盒) activation by targeting of insulin-like growth factor-binding protein-3.
Increased IGF-1 (显示 IGF1 ELISA试剂盒) or IGFBP-3 in subcutaneous adipose tissue of acromegaly do not appear to contribute to systemic differences in insulin (显示 INS ELISA试剂盒) sensitivity.
The monoclonal gammopathy of undetermined significance and multiple myeloma patients displayed a significant increase in intact IGFBP-2 (显示 IGFBP2 ELISA试剂盒) and decrease in intact IGFBP-3 in the circulation compared to control individuals.
our studies found that the deletion of IGFBP3 results in behavioral impairments that are associated with abnormal synaptic function and monoaminergic neurotransmission, which helps to characterize the critical role of IGFBP3 in the brain
IGFBP-3 is an aggravating factor during hepatic ischemia-repefusion injury.
An increase in IGFBP-3 post-trauma may play an important role in limiting trauma-induced inflammatory and apoptotic pathways leading to retinal damage.
Even though knockout of IGFBP-3 is associated with only a subtle phenotype under control conditions, our results reveal that loss of this gene has measurable effects on breast carcinogenesis and breast cancer metastasis.
Igfbp3 is a marker for culture-activated hepatic stellate cells and plays a role in HSC (显示 FUT1 ELISA试剂盒) migration.
Igfbp2 (显示 IGFBP2 ELISA试剂盒)-5 are expressed in distinct and complementary patterns during cochlear development.
IGFBP-3 has novel protective effects on retinal and systemic vasculature and may be a therapeutic candidate for ocular complications such as diabetic retinopathy.
IGFBP-3 activates inhibitory Smad (显示 SMAD1 ELISA试剂盒) signaling in 3T3-L1 cells and that endogenous IGFBP-3 modulates their adipogenic differentiation by regulating cell sensitivity towards the inhibitory effect of TGFbeta (显示 TGFB1 ELISA试剂盒).
Wnt (显示 WNT2 ELISA试剂盒) signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3.
IGFBP-3 positively and negatively impacts on IGF1 (显示 IGF1 ELISA试剂盒)-induced lung cancer development.
These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 (显示 NR4A1 ELISA试剂盒) to the cytoplasm where it exerts its apoptotic effect.
The present study suggests that the insulin (显示 INS ELISA试剂盒) like growth factor (IGF) system or imbalances between IGF and IGF binding (显示 HTRA1 ELISA试剂盒) proteins may be involved in cystic ovary disease of cattle.
spatial and temporal patterns of expression of IGFBP-2 (显示 IGFBP2 ELISA试剂盒) and -3 were markedly altered in the placentomes of nuclear transfer pregnancies
stimulation of IGFBP-3 mRNA levels by mitogens is regulated through both the PI3K and MAPK (显示 MAPK1 ELISA试剂盒) pathways in bovine mammary epithelial cells
Preincubation of erythroid cells with thrombospondin 1 (显示 THBS1 ELISA试剂盒) eliminated the inhibitory activity of IGFBP-3
GH, IGF-I (显示 IGF1 ELISA试剂盒) and IGF-IBP3 regulated the growth and development traits in different growth period.
delivery of insulin-like growth factor-1 (IGF-1 (显示 IGF1 ELISA试剂盒), delivered at concentrations of 0, 10, 50, and 100 ng/mL) affects the endogenous expression of IGF-1 (显示 IGF1 ELISA试剂盒), its receptor (IGF-1R (显示 IGF1R ELISA试剂盒)), and a well known IGF-1 (显示 IGF1 ELISA试剂盒) binding protein (IGFBP-3) by articular chondrocytes
Multivariable adjusted analyses did not reveal a statistically significant linear relationship between IGF1 (显示 IGF1 ELISA试剂盒) or IGFBP3 concentrations or their molar ratio and risk of myocardial infarction
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
IGF-I (显示 IGF1 ELISA试剂盒), IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
Increased oxidative stress from high glucose enhances IGFBP-3 expression, inducing apoptosis
Even though LRP-1 (显示 LRP1 ELISA试剂盒) mRNA and protein levels were dramatically reduced in LRP-1 (显示 LRP1 ELISA试剂盒)-silenced L6 cells compared with mock-silenced controls, rpIGFPB-3 suppressed proliferation rate to the same extent in both LRP-1 (显示 LRP1 ELISA试剂盒)-silenced and mock-silenced cultures.
cloning and sequencing; regulation of IGFBP-3 transcription by FSH (显示 BRD2 ELISA试剂盒) suggests a role for IGFBP-3 in follicular development that may be independent of IGF-I (显示 IGF1 ELISA试剂盒)
Follicle-stimulating hormone stimulation of IGFBP-3 transcription is mediated by cAMP via the PKA pathway and requires the P1-3 kinase and likely the MAPK (显示 MAPK1 ELISA试剂盒) pathways.
TAF4b may thus be the TFIID (显示 TBP ELISA试剂盒) component that binds to the TBP (显示 TBP ELISA试剂盒) site on the IGFBP-3 promoter and is essential for FSH (显示 BRD2 ELISA试剂盒) induction of IGFBP-3.
The results suggest that the expression of IGF2 and IGFBP3 mRNA in the adipose tissue of pigs exhibits specific developmental changes and different patterns between the two pig breeds.
allelic frequency of TAT (显示 C6orf134 ELISA试剂盒) in Chinese breeds was over 50%; allelic frequency of GGC (显示 GGCT ELISA试剂盒) was over 50% in all European breeds. TAT/TAT (显示 C6orf134 ELISA试剂盒) pigs scored higher in meat color than GGC/GGC (显示 GGCT ELISA试剂盒) pigs. results implied that IGFBP-3 may affect meat quality & carcass traits.
Data suggest that metabolism of IGFBP3, IGF1 (insulin-like growth factor I), and IGF2 (insulin-like growth factor II) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
insulin-like growth factor-binding protein 3
, insulin-like growth factor binding protein 3
, IGF-binding protein 3
, acid stable subunit of the 140 K IGF complex
, binding protein 29
, binding protein 53
, growth hormone-dependent binding protein
, insulin-like growth factor binding protein-3
, insulin-like growth factor-binding protein (IGF-BP3)