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Human POMC ELISA Kit for Competition ELISA - ABIN414616
Zapletal, Kraus, Cupi?, Gabrilovac: Differential expression of proopiomelanocortin (POMC) transcriptional variants in human skin cells. in Neuropeptides 2013
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (显示 AGRP ELISA试剂盒) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
disruption of this hippocampal POMC/MC4R (显示 MC4R ELISA试剂盒) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (显示 AGRP ELISA试剂盒) to POMC neuron GABA connectivity depends on the state of AgRP (显示 AGRP ELISA试剂盒) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (显示 LEP ELISA试剂盒) sensitivity and glucose sensing of POMC neurons.
it is suggested that the suppression of NeuroD1 (显示 NEUROD1 ELISA试剂盒) expression and the inhibition of NeuroD1 (显示 NEUROD1 ELISA试剂盒)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc.
To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons.
Epo (显示 EPO ELISA试剂盒) regulates hypothalamus POMC expression via STAT3 (显示 STAT3 ELISA试剂盒) activation.
Data suggest that the solitary tract pro-opiomelanocortin (NTSPOMC) neurons were involved in cardiorespiratory control and endogenous analgesia.
hypothalamic arcuate nucleus (Arc (显示 NOL3 ELISA试剂盒))POMC-deficient mice, which develop severe obesity and insulin (显示 INS ELISA试剂盒) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 (显示 SLC2A2 ELISA试剂盒) expression and glycosuria.
Hypomethylation of POMC promoter occurred in the hypothalamus of the high sucrose diet offspring compared with controls.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (显示 FN1 ELISA试剂盒) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (显示 TNF ELISA试剂盒), IL-6 (显示 IL6 ELISA试剂盒) and IL-8 (显示 IL8 ELISA试剂盒)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (显示 POU1F1 ELISA试剂盒), SF-1 (显示 NR5A1 ELISA试剂盒), and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (显示 MC4R ELISA试剂盒)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (显示 APOE ELISA试剂盒)) and agouti-related protein (AGRP (显示 AGRP ELISA试剂盒)) with obesity in the North Indian population.
The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
hsa (显示 CD24 ELISA试剂盒)-miR (显示 MLXIP ELISA试剂盒)-34a can regulate the CRH (显示 CRH ELISA试剂盒)/CRHR1 (显示 CRHR1 ELISA试剂盒)/POMC axis and may influence body mass index.
these common variants in PCSK1 (显示 PCSK1 ELISA试剂盒) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (显示 PCSK1 ELISA试剂盒) did affect cholesterol level, LDL-C level, and waist circumference.
ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
CSF (显示 CSF2 ELISA试剂盒) POMC was higher in lean vs. overweight/obese subjects.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (显示 PENK ELISA试剂盒)) and prodynorphin (PDYN (显示 PDYN ELISA试剂盒)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (显示 CRH ELISA试剂盒) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (显示 GJA1 ELISA试剂盒) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (显示 PHB2 ELISA试剂盒); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2