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Study show that YAP is overexpressed in chronic myeloid leukemia (CML) cells and indicate that YAP may play an important role in the proliferation and leukemogenesis of CML cells.
Studies indicate that the transcriptional co-activators YAP and TAZ (显示 TAZ ELISA试剂盒) recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM (显示 MMRN1 ELISA试剂盒)) elasticity and cell shape.
Study shows that force applied to the nucleus directly drives YAP nuclear translocation by decreasing the mechanical restriction of nuclear pores to molecular transport.
YAP negatively regulates differentiation of Vascular smooth muscle cells (VSMCs) derived from cardiovascular progenitor cell (CVPC) by decreasing transcription of myocardin (显示 MYOCD ELISA试剂盒) in a NKX2.5 (显示 NKX2-5 ELISA试剂盒)-dependent manner.
Studied the effect of TEAD4 (显示 TEAD4 ELISA试剂盒) acylation on its interaction with YAP and TAZ (显示 TAZ ELISA试剂盒); found YAP and TAZ (显示 TAZ ELISA试剂盒) bind in a similar manner to both acylated and non-acylated TEAD4 (显示 TEAD4 ELISA试剂盒). Also found TEAD4 (显示 TEAD4 ELISA试剂盒) acylation significantly enhances its stability.
results demonstrated that miR (显示 MLXIP ELISA试剂盒)-195-5p was a potent suppressor of YAP1, and miR (显示 MLXIP ELISA试剂盒)-195-5p-mediated downregulation of YAP1 significantly reduced tumor development in a mouse colorectal cancer xenograft model.
Data indicate an activation of Yes-associated protein 1 (YAP1) signaling after platelet incubation.
YAP expression and progesterone receptor (显示 PGR ELISA试剂盒) status were independent favorable predictors of disease-free survival and overall survival, respectively, among patients with breast cancer.
Our findings suggest that LATS1 is a potential candidate tumor suppressor and inhibits the growth and metastasis of gastric carcinoma cells via downregulation of the YAP signaling.
14-3-3zeta recruited YAP and p-LATS to form a complex under high cells density status and 14-3-3zeta other than YAP or phospho-LATS was the key regulatory molecule of this complex.
Yap1 has a crucial role in controlling the limb regenerative capacity in Xenopus
YAP1 enhanced cementoblast mineralization in vitro. YAP1 exerted its effect on the cementoblast partly by regulating the Smad (显示 SMAD1 ELISA试剂盒)-dependent BMP and Erk1/2 (显示 MAPK1/3 ELISA试剂盒) signaling pathways.
A crucial role for YAP and TAZ (显示 TAZ ELISA试剂盒) in the maintenance of the postnatal adrenal cortex.
v-Src (显示 SRC ELISA试剂盒) prevents nuclear exclusion of YAP through a decrease in the phosphorylation of YAP at Ser127 in multinucleated cells.
Dystrophin-glycoprotein complex component dystroglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferation in mice
P38 MAPK (显示 MAPK14 ELISA试剂盒)-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration.
YAP1 exerted its effect on the chondrocyte differentiation by activating the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling pathway
Nuclear YAP does not play a significant physiological role during oocyte development in mammals.
identify the mesenchymal requirement of YAP/TAZ (显示 TAZ ELISA试剂盒) in the gastrointestinal tract and highlight the functional interplays between Hippo and Hedgehog (显示 SHH ELISA试剂盒) signaling underlying temporal and spatial control of tissue growth and specification in developing gut (显示 GUSB ELISA试剂盒)
findings indicate that HIF-2alpha (显示 EPAS1 ELISA试剂盒) increases cancer cell growth by up-regulating YAP1 activity
found that epidermal YAP activity drives GLI2 (显示 GLI2 ELISA试剂盒) nuclear accumulation in the skin of YAP2-5SA-DeltaC mice, which depends on epidermal beta-catenin (显示 CTNNB1 ELISA试剂盒) activation
YAP activation is a hallmark of malignant brain tumours.
During vascular regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression.
that Yap1 entered the nucleus and promoted transcription in response to blood flow.
that Yap1 integrates the anabolic demands of tissue growth during development and tumorigenesis by reprogramming nitrogen metabolism to stimulate nucleotide biosynthesis
Amotl2a (显示 AMOTL2 ELISA试剂盒) function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 and the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) effector Lef1 (显示 LEF1 ELISA试剂盒).
data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development
Yap/Taz (显示 TAZ ELISA试剂盒)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.
Yap is essential for fin regeneration and that its function is dependent on mechanical tension, conferred by a balancing act of cell density and cytoskeleton activity.
When transcriptional coactivators Yap and Taz (显示 TAZ ELISA试剂盒) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.
Yap coordinately regulates cell proliferation and apoptosis and is required for dorsoventral axis formation, gastrulation, cardiogenesis, hematopoiesis, and somitogenesis.
The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.
65 kDa Yes-associated protein
, yes-associated protein 2
, yorkie homolog
, Yes-associated protein 1, 65kDa
, Yes-associated protein 1, 65 kD
, yes-associated protein, 65 kDa