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MAD1 (显示 MXD1 ELISA试剂盒) and Proto-Oncogene (显示 RAB1A ELISA试剂盒) Proteins c-myc (显示 MYC ELISA试剂盒) reciprocally regulate ribosomal DNA transcription, providing a mechanism for coordination of ribosome biogenesis and cell growth
MAD1 (显示 MXD1 ELISA试剂盒) is present in mouse oocytes at all stages during the first meiosis and that it participates in spindle checkpoint during meiosis
Data show that the loss of Trrap (显示 TRRAP ELISA试剂盒) leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap (显示 TRRAP ELISA试剂盒)-mediated transcription of the mitotic checkpoint (显示 BUB3 ELISA试剂盒) proteins Mad1 (显示 MXD1 ELISA试剂盒) and Mad2 (显示 MXI1 ELISA试剂盒).
identified mouse Telomeric Repeat Binding Factor 1 (Trf1 (显示 TERF1 ELISA试剂盒)) as a protein that interacts directly with the spindle checkpoint protein Mad1 (显示 MXD1 ELISA试剂盒) and the mitotic kinase Nek2 (显示 NEK2 ELISA试剂盒)
Together these data demonstrate that the MYC (显示 MYC ELISA试剂盒)-antagonist MAD1 (显示 MXD1 ELISA试剂盒) and cyclin-dependent kinase inhibitor p27(Kip1 (显示 CDKN1B ELISA试剂盒)) cooperate to regulate the self-renewal and differentiation of HSCs in a context-dependent manner.
the simultaneous knockdown of p18 (显示 CDKN2C ELISA试剂盒), p27 (显示 CDKN1B ELISA试剂盒) and MAD1 (显示 MXD1 ELISA试剂盒) with a medium of only stem cell factor (显示 KITLG ELISA试剂盒) can induce long-term culture-initiating cell expansion despite the loss of engraftment ability
This study showed that MAD1L1 as a susceptibility gene for both of these genetically overlapping disorders is associated with a decreased bottom-up responsiveness of the mesolimbic reward system and related cortical regions involved in the salience network as well as with reduced top-down control processes.
Results show that low DNA methylation (显示 HELLS ELISA试剂盒) levels of LINC00682, MAD1L1, and LINE-2 was strongly correlated with hepatocellular carcinomas recurrence, patient disease-free survival, and/or overall survival.
MAD1L1 positive expression may be associated with tumour progression and metastasis in small-cell lung cancer (SCLC) and may thus serve as a new biomarker for prognosis in these patients.
In this review, we highlight a novel Mad1 role in chromosome alignment, which is the first conserved mechanism that links the spindle assembly checkpoint and kinesin-mediated chromosome gliding.
MAD1L1 Arg558His and MAD2L1 (显示 MAD2L1 ELISA试剂盒) Leu84Met interaction with smoking increase the risk of colorectal cancer
MAD1L1 rs12666575 polymorphism may play a protective role against schizophrenia (SCZ) in the Chinese population. rs12666575 may be associated with general psychopathology and thought disturbance in SCZ patients.
We also show that replication perturbations result in relocalization of MAD1 (显示 MXD1 ELISA试剂盒)/MAD2 (显示 MAD2L1 ELISA试剂盒) in human cells, suggesting that the role of SAC (显示 ADCY10 ELISA试剂盒) in DNA repair is conserved.
Mad1 (显示 MXD1 ELISA试剂盒) has a role in secretion and cell migration.
MAD1 (显示 MXD1 ELISA试剂盒) kinetochore localization dictates the spindle assembly checkpoint in metaphase.
This article reviews Mad1 (显示 MXD1 ELISA试剂盒) and Mad2 (显示 MAD2L1 ELISA试剂盒) - structural and functional relationship with implication in genetic diseases, specifically in cancer. [review]
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.
MAD1-like protein 1
, mitotic arrest deficient 1-like 1
, mitotic arrest deficient 1-like protein 1
, mitotic spindle assembly checkpoint protein MAD1
, mitotic checkpoint MAD1 protein homolog
, mitotic-arrest deficient 1, yeast, homolog-like 1
, tax-binding protein 181
, tumor protein p53 inducible protein 9