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Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha.
The major capsid protein of the mouse polyomavirus VP1 binds microtubules, HSP90 (显示 HSP90 ELISA试剂盒), promotes their acetylation and blocks the host cell cycle.
Artificially maintaining Hsp90alpha or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes.
Immune-mediated destruction of ovarian follicles associated with the presence of HSP90 (显示 HSP90 ELISA试剂盒) antibodies.
identify that Hsp90alpha at the transition neck region represents a signalling platform on which IRS-1 (显示 IRS1 ELISA试剂盒) interacts with intracellular downstream signalling molecules involved in IGF-1 (显示 IGF1 ELISA试剂盒) receptor signalling.
The study demonstrated that HSP90alpha plays an important role in the biogenesis of fetal PIWI-interacting RNAs (piRNA), which act against the transposon activities, in mouse male germ cells.
Data show that the heat shock protein 90 (HSP90 (显示 HSP90 ELISA试剂盒)) isoforms HSP90AA1 and HSP90AB1 (显示 HSP90AB1 ELISA试剂盒) are responsible for maintaining proper cellular levels of BMAL1 (显示 ARNTL ELISA试剂盒) protein.
deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation
study identified the essential role of Hsp90 (显示 HSP90 ELISA试剂盒) in iNOS (显示 NOS2 ELISA试剂盒) gene transactivation
Hsp90alpha may be required to maintain and to activate these regulators and/or to disassemble the synaptonemal complex that holds homologous chromosomes together
FKBP51 (显示 FKBP4 ELISA试剂盒) is primarily localized in mitochondria and hTERT is totally nuclear, upon the onset of oxidative stress, FKBP51 (显示 FKBP4 ELISA试剂盒) (but not FKBP52 (显示 FKBP4 ELISA试剂盒)) becomes mostly nuclear colocalizing with hTERT, and longer exposure times to peroxide favors hTERT export to mitochondria.
High HSP90 (显示 HSP90 ELISA试剂盒) expression is associated with Colorectal Cancers.
High HSP90 (显示 HSP90 ELISA试剂盒) expression is associated with prostate cancer.
Data suggest HSP90AA1-dependent regulation of ATM-NBN-CHK2 and ATR-CHK1 axes influences cells capability to repair double-stranded DNA damage; mechanisms include phosphorylation, polyubiquitination, and proteasomal degradation/proteolysis. (HSP90AA1 = heat shock protein 90kDa alpha; ATM = ataxia telangiectasia mutated protein; NBN = nibrin; CHK = checkpoint kinase; ATR = ataxia telangiectasia and Rad3 related kinase)
Data show that pyruvate kinase M2 (PKM2) directly interacted with mutant growth factor receptor (显示 RYK ELISA试剂盒) (EGFR (显示 EGFR ELISA试剂盒)) and heat-shock protein 90 (HSP90 (显示 HSP90 ELISA试剂盒)), and thus stabilized EGFR (显示 EGFR ELISA试剂盒) by maintaining its binding with HSP90 (显示 HSP90 ELISA试剂盒) and co-chaperones.
Binding of FM807 to the N-terminus of Hsp90 (显示 HSP90 ELISA试剂盒) disrupted Hsp90 (显示 HSP90 ELISA试剂盒)/client complexes, resulting in degradation of the Hsp90 (显示 HSP90 ELISA试剂盒) client protein EGFR (显示 EGFR ELISA试剂盒) and inhibition of the downstream pathway.
Conventional as well as scaled molecular dynamics simulations further demonstrate that citrullination of selected Arg residues leads to progressive disruption of HSP90 tertiary structure, promoting exposure of R502/R510 to PAD modification and subsequent autoantibody binding.
SYK (显示 SYK ELISA试剂盒) is an HSP90 (显示 HSP90 ELISA试剂盒) client protein, and B-cell receptor signaling-dependent phosphorylation of HSP90 (显示 HSP90 ELISA试剂盒) on Y197 is required for this interaction. HSP90 (显示 HSP90 ELISA试剂盒) promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling.
There is overwhelming evidence that molecular chaperones such as Hsp27 (显示 HSPB1 ELISA试剂盒), Hsp70 (显示 HSP70 ELISA试剂盒) and Hsp90 (显示 HSP90 ELISA试剂盒) are expressed at elevated levels in a wide range of cancers by stabilizing the mutated neoplasm proteins. (Review)
Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase (显示 NMNAT1 ELISA试剂盒) 2 (NMNAT2 (显示 NMNAT2 ELISA试剂盒)), independent from its enzymatic activity, and NMNAT2 (显示 NMNAT2 ELISA试剂盒) complexes with heat shock protein 90 (HSP90 (显示 HSP90 ELISA试剂盒)) to refold aggregated protein substrates.
This study firstly found that host chaperone heat shock protein 90 (Hsp90 (显示 HSP90 ELISA试剂盒)) had a positive regulatory effect on the porcine circovirus type 2 infection cycle in vitro.
Feed intake remains low whereas respiratory frequency and body temperature remain higher and expression of HSP90 (显示 HSP90 ELISA试剂盒), CAT1 (显示 SLC7A1 ELISA试剂盒), SGLT1 (显示 SLC5A1 ELISA试剂盒) and GLUT4 (显示 SLC2A4 ELISA试剂盒) increases in some tissues in pigs under chronic heat stress conditions.
HSP90AA1 sperm content and the prediction of the boar ejaculate freezability.
Hsp90 (显示 HSP90 ELISA试剂盒) is a modulator of eNOS (显示 NOS3 ELISA试剂盒) activity and vascular reactivity in the newborn piglet pulmonary circulation
Apo (显示 C9orf3 ELISA试剂盒)-Hsp90 (显示 HSP90 ELISA试剂盒) is in a conformational equilibrium between two open states that have never been described previously.
Findings indicate an essential role for Hsp90 (显示 HSP90 ELISA试剂盒) in nongenomic estrogen signaling in coronary artery smooth muscle cells.
Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of HSP90AA1 and PGES (prostaglandin-E synthase (显示 PTGES ELISA试剂盒)).
This study showed that ubiquitinated ALK5 (显示 TGFBR1 ELISA试剂盒) and phosphorylated heat shock protein 27 (显示 HSP27 ELISA试剂盒) specifically accumulate in the cytoskeleton fraction, and ALK1 (显示 ACVRL1 ELISA试剂盒) and ALK5 (显示 TGFBR1 ELISA试剂盒) interact with heat shock protein 90(HSP90 (显示 HSP90 ELISA试剂盒)).
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
Heat Shock Protein 90, cytosolic
, heat shock protein 90A
, molecular chaperone
, HSP 86
, heat shock 86 kDa
, heat shock protein 1, alpha
, heat shock protein 90kDa alpha (cytosolic), class A member 1
, heat shock protein HSP 90-alpha
, heat shock protein, 1
, heat shock protein, 86 kDa 1
, heat shock protein, 89 kDa
, tumor-specific transplantation 86 kDa antigen
, heat shock protein 86
, epididymis luminal secretory protein 52
, heat shock 90kD protein 1, alpha
, heat shock 90kD protein 1, alpha-like 4
, heat shock 90kD protein, alpha-like 4
, heat shock 90kDa protein 1, alpha
, renal carcinoma antigen NY-REN-38
, heat shock protein HSP90 alpha
, hypothetical protein
, 90-kDa heat shock protein
, Heat shock protein HSP 90-alpha-like protein
, Hsp90 alpha
, heat shock protein 90 alpha
, heat shock protein 90kDa alpha, class A member 1