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Rat (Rattus) Arrestin 3 ELISA Kit for Sandwich ELISA - ABIN810989
Oda, Tadokoro, Takase, Kanahara, Watanabe, Shirayama, Hashimoto, Iyo: G protein-coupled receptor kinase 6/?-arrestin 2 system in a rat model of dopamine supersensitivity psychosis. in Journal of psychopharmacology (Oxford, England) 2015
EPCR (显示 PROCR ELISA试剂盒) occupancy recruits G-protein coupled receptor kinase 5 (显示 GRK5 ELISA试剂盒), thereby inducing beta-arrestin-2 biased PAR1 (显示 MARK2 ELISA试剂盒) signaling by both APC (显示 APC ELISA试剂盒) and thrombin (显示 F2 ELISA试剂盒). In
CCR5 (显示 CCR5 PLURAL_@2305@) is highly expressed in active inflammatory bowel disease, and it has positive correlation with lymphocyte grade and negative correlation with expression of beta-arrestin2.
Data suggest that PAR4 (显示 PAWR ELISA试剂盒) and P2Y12 (显示 P2RY12 ELISA试剂盒) heterodimer internalization/endocytosis is required for beta-arrestin-2 recruitment to endosomes and up-regulation of Akt (显示 AKT1 ELISA试剂盒) signaling; activation of PAR4 (显示 PAWR ELISA试剂盒) but not of P2Y12 (显示 P2RY12 ELISA试剂盒) drives internalization of the PAR4 (显示 PAWR ELISA试剂盒)-P2Y12 (显示 P2RY12 ELISA试剂盒) heterodimer. (PAR4 (显示 PAWR ELISA试剂盒) = protease-activated receptor 4 (显示 F2RL3 ELISA试剂盒); P2Y12 (显示 P2RY12 ELISA试剂盒) = purinergic receptor P2Y (显示 P2RY1 ELISA试剂盒), G-protein coupled, 12 protein; Akt (显示 AKT1 ELISA试剂盒) = proto-oncogene (显示 RAB1A ELISA试剂盒) protein c (显示 PROC ELISA试剂盒)-akt (显示 AKT1 ELISA试剂盒))
Analyzing the functional relevance of individual sites using phosphosite-deficient receptor mutants we found phosphorylation of the ADRB1 (显示 ADRB1 ELISA试剂盒) at Ser461/Ser462 in the distal part of the C-terminus to determine beta-arrestin2 recruitment and receptor internalization
Heterodimerization of the kappa opioid receptor (显示 OPRK1 ELISA试剂盒) and neurotensin receptor 1 contributes to a novel beta-arrestin-2-signaling pathway.
These results were consistent with those seen for beta2-AR. Thus, both beta-arrs negatively control AM1 receptor internalization, which depends on the C-tail of CLR (显示 DCLK3 ELISA试剂盒).
The downregulation of beta-arrestins 1/2 in saphenous vein endothelial cells (SVECs) prevented the shear stress-induced rise in levels of phosphorylation of Akt (显示 AKT1 ELISA试剂盒) and endothelial nitric oxide synthase (eNOS (显示 NOS3 ELISA试剂盒), Serine 1177).
CRIP1a (显示 CRIP1 ELISA试剂盒) can compete with beta-arrestins for interaction with C-terminal CB1R (显示 CNR1 ELISA试剂盒) domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R (显示 CNR1 ELISA试剂盒).
RACK1 (显示 GNB2L1 ELISA试剂盒) and beta-arrestin2 inhibit the dimerization of PDE4D5.
Suggest that fenoterol inhibited AICAR (显示 ATIC ELISA试剂盒)-induced AMPK (显示 PRKAA1 ELISA试剂盒) alpha1 activation and TNF-alpha (显示 TNF ELISA试剂盒) release through beta-arrestin-2 in THP-1 (显示 GLI2 ELISA试剂盒) cells.
The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 (显示 CCR5 PLURAL_@2305@) internalization.
K2A mutations in arrestin-1 (显示 SAG ELISA试剂盒), -2, and -3 significantly reduced their binding to active phosphorhodopsin.
Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
AT1R (显示 AGTRAP ELISA试剂盒)-beta-arrestin-2 pathway signaling plays an important role in renal fibrosis.
These data suggest that one allele of arrestin-2 (显示 ARRB1 ELISA试剂盒) is unable to support normal locomotor behavior due to signaling and/or developmental defects.
Beta-arrestin-2 with beta-arrestin-1 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
[beta]-arrestin2 regulates intestinal mucosal inflammation under both homeostatic and colitic conditions. Its mode of action involves negative regulation of T-cell activation and its requirement for induction of regulatory T cells.
Results suggest that the antipruritic effects of kappa opioid receptor (显示 OPRK1 ELISA试剂盒) agonists may not require betaarrestin2
that pro- and anti-inflammatory activities of beta-arrestin2 are determined by beta-arrestin2 ubiquitination and that changes in USP20 (显示 USP20 ELISA试剂盒) expression and/or activity can therefore regulate inflammatory responses
This shows that mood stabilizers lamotrigine, lithium and valproate can exert behavioral effects in mice by disrupting the beta-arrestin 2-mediated regulation of Akt (显示 AKT1 ELISA试剂盒)/GSK3 (显示 GSK3b ELISA试剂盒) signaling by D2 dopamine receptors.
findings show for the first time that Ang II (显示 AGT ELISA试剂盒) receptor signaling to beta-arrestin regulates ARF6 (显示 ARF6 ELISA试剂盒) activation. These proteins together control receptor endocytosis and ultimately cell migration.
These results reveal that the protective effect of deficiency of Arrb2 is due to loss of negative regulation of Akt (显示 AKT1 ELISA试剂盒).
that Insulin-like growth factor-1 (显示 IGF1 ELISA试剂盒) contributes to the mucosal repair by beta-arrestin2-mediated extracellular signal-regulated kinase signaling in experimental colitis
Arrb2 physically interacts with the beta subunit (显示 POLG ELISA试剂盒) of trimeric G-proteins and Dishevelled (显示 DVL2 ELISA试剂盒), the interaction between arrb2 and Dishevelled (显示 DVL2 ELISA试剂盒) is promoted by the beta/gamma subunits of trimeric G-proteins.
results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog (显示 SHH ELISA试剂盒) signaling in zebrafish development
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
arrestin beta 2
, arrestin, beta 2
, arrestin 2
, beta-Arrestin 2
, arrestin beta-2
, arrestin 3
, beta arr2
, beta-arrestin 2