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Human Endothelin 1 ELISA Kit for Competition ELISA - ABIN415024
Yang, Chen, Yuan, Fang, Cheng, Xia, Fang, Xu, Gao: Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1. in Nucleic acids research 2013
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Rat (Rattus) Endothelin 1 ELISA Kit for Competition ELISA - ABIN416287
Xing, Zhang, Li, Huang, Luo, Hei, Xia, Gan: Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning. in The Journal of surgical research 2014
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Rat (Rattus) Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN366462
Huang, Tang, Liang, Wen, Zhang, Xuan, Jian, Lin, Huang: The effects of 17-methoxyl-7-hydroxy-benzene-furanchalcone on the pressure overload-induced progression of cardiac hypertrophy to cardiac failure. in PLoS ONE 2014
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Human Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN1672856
Agapitov, Haynes: Role of endothelin in cardiovascular disease. in Journal of the renin-angiotensin-aldosterone system : JRAAS 2002
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Rat (Rattus) Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN1672857
Liu, Zhu, Zhou, Wei, Long, Chen, Ling, Ge, Zhuo: Endoplasmic reticulum stress promotes amyloid-beta peptides production in RGC-5 cells. in Cell stress & chaperones 2014
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Mouse (Murine) Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN1672858
Peng, Dai, Ji, Dai: The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. in European journal of pharmacology 2010
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Human Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN837829
Lacedonia, Valerio, Palladino, Carpagnano, Correale, Biase, Barbaro: Role of vasoactive intestinal Peptide in chronic obstructive pulmonary disease with pulmonary hypertension. in Rejuvenation research 2014
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Mouse (Murine) Endothelin 1 ELISA Kit for Competition ELISA - ABIN415566
Song, Zhu, Li: Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice. in Clinics (São Paulo, Brazil) 2013
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Human Endothelin 1 ELISA Kit for Sandwich ELISA - ABIN455023
Ouyang, Li, Li, Cai, Chen, Chen, Chen, Yang, Xie: Mitochondrial ROS-K+ channel signaling pathway regulated secretion of human pulmonary artery endothelial cells. in Free radical research 2012
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Pig (Porcine) Endothelin 1 ELISA Kit for Competition ELISA - ABIN3155739
Gallinat, Efferz, Paul, Minor: One or 4 h of "in-house" reconditioning by machine perfusion after cold storage improve reperfusion parameters in porcine kidneys. in Transplant international : official journal of the European Society for Organ Transplantation 2014
Study shows that cerebrovascular muscle cells can express endothelin-1 (ET-1). The production of ET-1 in cerebrovascular muscle cells stimulated by oxyhemoglobin occurs partially through the NF-[kappa]B signal pathway.
Plasma ET-1 levels of rabbits increased significantly in fluorinated groups compared with those in the control group.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (显示 ALMS1 ELISA试剂盒) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (显示 ACE ELISA试剂盒).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (显示 EDNRA ELISA试剂盒)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (显示 NFKB1 ELISA试剂盒) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (显示 CA2 ELISA试剂盒)+ transients in atrial myocytes through Ins (显示 INS ELISA试剂盒)(1,4,5)P3-dependent Ca2 (显示 CA2 ELISA试剂盒)+ release from perinuclear Ca2 (显示 CA2 ELISA试剂盒)+ stores
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (显示 MAPK14 ELISA试剂盒) kinase-mediated production of superoxide from NADPH oxidase (显示 NOX1 ELISA试剂盒) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (显示 HEBP1 ELISA试剂盒) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (显示 EDNRA ELISA试剂盒)) receptors coupled to extracellular Ca(2 (显示 CA2 ELISA试剂盒)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (显示 IL6 ELISA试剂盒), endothelin ET-1, and apoptotic Bak (显示 BAK1 ELISA试剂盒) and Bcl-XL (显示 BCL2L1 ELISA试剂盒) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (显示 SRC ELISA试剂盒) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (显示 ECE1 ELISA试剂盒)) acting via endothelin receptor A (显示 EDNRA ELISA试剂盒) in the control of luteolytic sensitivity in the pig
this study did not find any significant differences of ET-1 level between obstetric antiphospholipid syndrome and thrombotic antiphospholipid syndrome
Polymorphic variants of endothelin EDN (显示 RNASE2 ELISA试剂盒) (K198N) and endothelin receptor type A (显示 EDNRA ELISA试剂盒) genes EDN (显示 RNASE2 ELISA试剂盒) RA (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for normal tension glaucoma.
high glucose and free fatty acids reduced NO and increased ET-1 levels induced by acetylcholine through the modulation of intracellular calcium concentrations and endothelial NO synthase (显示 NOS ELISA试剂盒) phosphorylation, events also reverted by hydroxytyrosol and polyphenol extract.
In both the acute and remission phase of thrombotic thrombocytopenic purpura we found increased CT-proET-1 and VWF (显示 VWF ELISA试剂盒) levels, while Factor H (显示 CFH ELISA试剂盒) levels decreased compared with healthy controls. In remission, however, the elevated CT-proET-1 levels showed a 22 % decrease when compared with the acute phase.
ET-1 increased NSCLC clonal growth, whereas BQ123, ZD4054, lapatinib or gefitinib inhibited proliferation. The results indicate that ET-1 may regulate NSCLC cellular proliferation in an EGFR (显示 EGFR ELISA试剂盒)- and HER2 (显示 ERBB2 ELISA试剂盒)-dependent manner
Data indicate that patients with systemic sclerosis (SSc (显示 CYP11A1 ELISA试剂盒)) displayed higher serum levels of VEGF (显示 VEGFA ELISA试剂盒), endothelin-1 and s-Fractalkine (显示 CX3CL1 ELISA试剂盒), and that the s-Fractalkine (显示 CX3CL1 ELISA试剂盒) levels positively correlated with CD34 (显示 CD34 ELISA试剂盒)(+)CD45 (显示 PTPRC ELISA试剂盒)(-) endothelial progenitor cells (EPC (显示 TCF21 ELISA试剂盒)) numbers.
Endothelin-1 and its receptors on haemorrhoidal tissue: a potential site for therapeutic intervention
we could provide evidence that established stress-related biomarkers ET-1, MCP-1 (显示 CCL2 ELISA试剂盒), CGA (显示 CGA ELISA试剂盒) were differentially regulated among patients with AF compared to healthy controls.
Two END1 (显示 VPS11 ELISA试剂盒) polymorphisms do not appear to affect the development of hypertension in the Chinese population.
TWEAK (显示 TNFSF12 ELISA试剂盒) may stimulate endothelial ET-1 synthesis, through the up-regulation of ECE-1 (显示 ECE1 ELISA试剂盒).
c-Src tyrosine kinase (显示 CSK ELISA试剂盒) mediates high glucose-induced endothelin-1 expression
SIX1 (显示 SIX1 ELISA试剂盒) regulates dorsal arch development not only by inducing dorsal Jag1 (显示 JAG1 ELISA试剂盒) expression but also by inhibiting endothelin 1 (Edn1) expression in the pharyngeal endoderm of the dorsal arch, thus preventing dorsal EDNRA (显示 EDNRA ELISA试剂盒) signaling.
NOX4 (显示 NOX4 ELISA试剂盒)-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 production.
in normal tissues the tandem of serine carboxypeptidases, Scpep1 (显示 SCPEP1 ELISA试剂盒) and CathA likely constitutes an important part of the physiological mechanism responsible for the balanced elimination of heightened levels of ET-1 that otherwise would accumulate in tissues and consequently contribute to development of the hyper-proliferative corneal dystrophy and abnormal skin thickening
Newborn endothelial cells express high levels of ET-1 peptides, rapidly release ET-1 in response to endothelial stimulation, and initiate ET-1-mediated endothelium-dependent constriction
cellular and molecular mechanisms of ET-1 action in periodontitis
Taken together, these data indicate that during high-salt feeding, the autocrine actions of ET-1 via upregulation of the ETB (显示 EDNRB ELISA试剂盒) receptor are critical for IMCD NO production, facilitating inhibition of ion reabsorption.
reduced lung levels of PPARgamma (显示 PPARG ELISA试剂盒) and increased levels of microRNA-27a (miR (显示 MLXIP ELISA试剂盒)-27a), v-ets (显示 ETS1 ELISA试剂盒) avian erythroblastosis virus E26 oncogene (显示 RAB1A ELISA试剂盒) homolog 1 (ETS1 (显示 ETS1 ELISA试剂盒)), endothelin-1 (ET-1), and markers of endothelial dysfunction (platelet/endothelial cell adhesion molecule 1 (显示 PECAM1 ELISA试剂盒) and E selectin (显示 SELE ELISA试剂盒)).
Increased circulating Edn1 and expression of Ednra (显示 EDNRA ELISA试剂盒) in endothelial cells are characteristic of diabetic kidney disease-susceptible mice.
Phylogenetic analysis of conserved grhl (显示 GHRL ELISA试剂盒)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (显示 GRHL3 ELISA试剂盒) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (显示 EDNRA ELISA试剂盒) (endothelin-1/endothelin-1 receptor type A (显示 EDNRA ELISA试剂盒)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (显示 DNAH8 ELISA试剂盒) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (显示 EDNRA ELISA试剂盒) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
EDN-1 may be involved in the protection of sperm from phagocytosis by polymorphonuclear neutrophils in the bovine oviduct, supporting sperm survival until fertilization
Data suggest that, in Fallopian tubes, endothelins (EDN1, EDN2 (显示 EDN2 ELISA试剂盒), EDN3 (显示 EDN3 ELISA试剂盒)) and EDN (显示 RNASE2 ELISA试剂盒)-converting enzymes (ECE1 (显示 ECE1 ELISA试剂盒), ECE2 (显示 ECE2 ELISA试剂盒)) are expressed in epithelial cells; EDN (显示 RNASE2 ELISA试剂盒) receptors (EDNRA (显示 EDNRA ELISA试剂盒), EDNRB (显示 EDNRB ELISA试剂盒)) are present in smooth-muscle. Expression of EDN1, EDN2 (显示 EDN2 ELISA试剂盒), and ECE2 (显示 ECE2 ELISA试剂盒) is highest on day of ovulation. EDN (显示 RNASE2 ELISA试剂盒)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
results suggest that ET-1-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (显示 NOX1 ELISA试剂盒)-PKCalpha (显示 PKCa ELISA试剂盒)-p(38)MAPK (显示 MAPK1 ELISA试剂盒) and NFkappaB-MT1MMP (显示 MMP14 ELISA试剂盒) signaling pathways along with a marked decrease in TIMP-2 (显示 TIMP2 ELISA试剂盒) expression in the cells
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (显示 PLA2G4A ELISA试剂盒) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (显示 NOS ELISA试剂盒) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (显示 OLR1 ELISA试剂盒) and CD40 (显示 CD40 ELISA试剂盒) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (显示 EDNRB ELISA试剂盒) during the peri (显示 PLIN1 ELISA试剂盒)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, gene for endothelin
, endothelin 1
, preproendothelin 1
, endothelin 1 L homeolog