anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) 抗体产品概述

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anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 抗体 (ABCC2)
在www.antibodies-online.cn可供57 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) 抗体的15不同的供货商。 再加上,我们可以发ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 蛋白 (10)ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 试剂盒 (5)和数多这个蛋白质的别的产品。 总共73 ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2产品已列进来了。
别名:
Abc30, AI173996, Cmoat, cMRP, DJS, Mrp2

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引用最多的anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 抗体

  1. Human Monoclonal ABCC2 Primary Antibody for ELISA, WB - ABIN4948190 : Takahashi, Miura, Scott, Kagaya, Kameoka, Tagawa, Saitoh, Fujishima, Yoshioka, Hirokawa, Sawada: Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia. in Journal of human genetics 2010 (PubMed)
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  2. Cow (Bovine) Polyclonal ABCC2 Primary Antibody for WB - ABIN610784 : Cockcroft, Thomas, Fensome, Geny, Cunningham, Gout, Hiles, Totty, Truong, Hsuan: Phospholipase D: a downstream effector of ARF in granulocytes. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 5 references for 610784

  3. Human Monoclonal ABCC2 Primary Antibody for IHC (fro), IF - ABIN1105169 : Peng, Yanagida, Chen, Han: Ellipsoidal TiO2 hierarchitectures with enhanced photovoltaic performance. in Chemistry (Weinheim an der Bergstrasse, Germany) 2012 (PubMed)
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  4. Human Monoclonal ABCC2 Primary Antibody for IHC (fro), IF - ABIN1105167 : Paulusma, Bosma, Zaman, Bakker, Otter, Scheffer, Scheper, Borst, Oude Elferink: Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. in Science (New York, N.Y.) 1996 (PubMed)
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  5. Human Monoclonal ABCC2 Primary Antibody for IHC (fro), IF - ABIN1105170 : Kool, de Haas, Scheffer, Scheper, van Eijk, Juijn, Baas, Borst: Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. in Cancer research 1997 (PubMed)
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更多抗ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2的相互作用对抗体

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. SMS (显示 SMS 抗体) regulates the expression and function of drug transporters P-gp (显示 ABCB4 抗体) and MRP2.

  2. genetic association studies in a population in France: Data that SNPs in ABCC2 are associated with regulation of secretion of endogenous organic anions; the 3 SNPs investigated (-24C>T, exon 1, rs717620; c.3972C>T, exon 28, rs3740066; c.1249G>A, exon 10, rs2273697) are associated with differential excretion of 35 of the 108 metabolites analyzed.

  3. BCRP (显示 ABCG2 抗体) and MRP2 can mediate elimination of ochratoxin A from cells, reducing OTA toxicity.

  4. Four SNPs within the APOE (显示 APOE 抗体) cluster (rs7412, rs4420638), ABCC2 (rs2002042) and CELSR/SORT1 (显示 SORT1 抗体)/PSRC1 (显示 PSRC1 抗体) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80

  5. We analyzed 150 SNPs in eight key genes involved in vincristine pharmacokinetics and in 13 miRNAs that regulate them. We studied their correlation with neurotoxicity during induction phase in 152 ALL patients treated with LAL (显示 LIPA 抗体)/SHOP protocols. The strongest associations with neurotoxicity were observed for two SNPs in ABCC2.

  6. In the present review we focus on the role of MRP2 in the apical membrane of the enterocytes, as an important component of this intestinal barrier, as well as on its regulation and provide a detailed compilation of significant contributions demonstrating that MRP2 expression and function vary under relevant physiological and pathophysiological conditions

  7. ABCC2 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients.

  8. Meta-analysis. The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs.

  9. we have investigated the role of ABCB1 (显示 ABCB1 抗体) rs1045642 and rs2032582 and ABCC2 rs2273697 and rs717620 in antiepileptic drug-resistance. Our study suggests that the ABCC2 rs717620 polymorphism is associated with resistance to antiepileptic drugs in Chinese patients with epilepsy.

  10. A novel deletion in ABCC2 gene was identified in families with dual hereditary jaundice.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) interaction partners

  1. Biotinylation and streptavidin pull-down assays confirmed that CAL (显示 S100A11 抗体) dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL (显示 S100A11 抗体) interacts with Mrp2 and is a negative regulator of Mrp2 expression.

  2. Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.

  3. In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.

  4. Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 (显示 ABCC1 抗体) and Mrp2, in WT cells but not in metallothionein (显示 MT 抗体)-null cells.

  5. hepatic transporters Ntcp (显示 SLC10A1 抗体) and Mrp2 are downregulated in rodent models of necrotizing enterocolitis

  6. Both Abcc2 and Abcc3 (显示 ABCC3 抗体) significantly influenced the PK properties of MTX (显示 MTX1 抗体).

  7. hyperosmotic cholestasis is triggered by a NADPH oxidase (显示 NOX1 抗体)-driven reactive oxygen species formation that mediates Fyn (显示 FYN 抗体)-dependent retrieval of the Mrp2 and Bsep (显示 ABCB11 抗体) from the canalicular membrane, which may involve an increased cortactin (显示 CTTN 抗体) phosphorylation.

  8. Strain- and sex-dependent circadian patterns in abcc2 expressions displayed robust relations with the chronotolerance of ileum mucosa for irinotecan

  9. In ABCC2-deficient mice impaired ABCC2 function is associated with a significant increase in erythromycin metabolism.

  10. Membrane vesicles prepared from human erythrocytes, which express the MRP2 have important implications for the Selenium-dependent and -independent disposition of Arasenic.

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine\; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Alternative names and synonyms associated with ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2)

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ABCC2) 抗体
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (Abcc2) 抗体
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (Abcc2) 抗体
  • Abc30 抗体
  • AI173996 抗体
  • Cmoat 抗体
  • cMRP 抗体
  • DJS 抗体
  • Mrp2 抗体

Protein level used designations for ABCC2

ATP-binding cassette sub-family C member 2 , canalicular multidrug resistance protein , canalicular multispecific organic anion transporter 1 , multidrug resistance-associated protein 2 , multidrug resistance protein 2 , ATP-binding cassette, sub-family C (CFTR/MRP), member 2 , calicular multispecific organic anion transporter , multidrug resistance associated protein 2

GENE ID SPECIES
1244 Homo sapiens
12780 Mus musculus
25303 Rattus norvegicus
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